Results 231 to 240 of about 399,922 (291)

An Interpretable Machine‐Learning Framework for Multi‐Endpoint Drug‐Induced Liver Injury Classification: Evaluating the Contribution of Molecular Structure

Advanced Computing, Volume 1, Issue 1, December 2026.
Molecular structure provides a complementary perspective on drug‐induced liver injury. Integrating 801 drugs across five DILI endpoints, our interpretable AI framework reveals endpoint‐dependent structural contributions and links predictive classification with molecular‐level interpretation, highlighting the complex interplay between clinical ...
Priya Kumari, Kunal Roy, Madhulika Gupta
wiley   +1 more source

Comparative Pharmacokinetics of Six Bioactive Constituents From Danggui Jixueteng Decoction in Normal and Myelosuppressive Rats

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study compared the pharmacokinetics of six constituents from Danggui Jixueteng Decoction in normal versus carboplatin‐induced myelosuppressive rats. A rapid, sensitive ultra‐high performance liquid chromatography‐tandem mass spectrometry method was developed and validated for simultaneous quantification of six diverse constituents (8‐O ...
Mingxin Guo, Yingjie Liu, Zhiqiang Hu, Xiayu Liu   +3 more
wiley   +1 more source

Optimizing germination and cultivation of edible halophytes using effluents from an IMTA system

Journal of the Science of Food and Agriculture, Volume 106, Issue 15, Page 8992-9006, December 2026.
Abstract BACKGROUND Halophytes offer nature‐based solutions to food insecurity and soil degradation, while their integration into integrated multi‐trophic aquaculture (IMTA) systems promotes circular economy practices. This study aimed to optimize the germination and cultivation of edible halophytic species, namely Limbarda crithmoides, Suaeda vera and
Viana Castañeda‐Loaiza, Maria João Rodrigues, Nuno Neng, Célia Quintas, Isabel Ratão, Luísa Custódio   +5 more
wiley   +1 more source

OATP1A2 mRNA downregulation in canine hepatocellular carcinoma

Veterinary Record Open, Volume 13, Issue 2, December 2026.
Abstract Background On gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA) magnetic resonance imaging, canine hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) typically exhibit low and high signal intensities in the hepatobiliary phase, respectively.
Shohei Kurokawa, Tomoki Motegi, Hideo Akiyoshi, Toshiyuki Tanaka   +3 more
wiley   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Severe chronic neutrophilic cholangiohepatitis with massive choledocholithiasis and hepatolithiasis in a pony

Equine Veterinary Education, Volume 38, Issue 12, Page e942-e950, December 2026.
Summary A 20‐year‐old Camargue pony mare was referred for acute‐onset neurological signs and intermittent colic. Clinical examination revealed obtundation, cranial nerve deficits, head pressing, ventral strabismus and ataxia. Laboratory analyses showed marked hyperammonaemia, hyperbilirubinemia, severe increases in liver enzymes, hypoalbuminaemia and ...
C. Maino, N. Ellero, M. Morini, L. V. Muscatello, S. Sabattini, G. Bettini   +5 more
wiley   +1 more source

Liver Injury Due to Hormonal Contraceptives in the Modern Era

Liver International, Volume 46, Issue 12, December 2026.
ABSTRACT Background and Aims Hormonal agents and their association with liver injury remain a concern in clinical practice. This study aimed to characterise the biochemical and clinical features of hormonal agent‐associated liver injury and compare them with a control group of age‐ and gender‐matched cases of liver injury caused by non‐hormonal drugs ...
Raj Vuppalanchi, A. Sidney Barritt, Anjali Rai, Huiman Barnhardt, Sherry Gu, Yi‐Ju Li, Naga Chalasani, for the Drug‐Induced Liver Injury Network, Naga Chalasani, Marwan Ghabril, Raj Vuppalanchi, Bob Fontana, Alisa Likhitsup, Vincent Chen, Victoria Shakhin, Paul Watkins, Sid Barritt, B. B. Behera, Jacquee Simpson, Herb Bonkovsky, Dee Faust, Andrew Stolz, Lily Dara, Neil Kaplowitz, Susan Milstein, Gina Choi, Jacqueline Nguyen, Angela Yeh, Dina Halegoua‐DeMarzio, Victor Navarro, Manish Thapar, Manisha Verma, Katrin Koy‐Pan, Verma Manisha, Cynthia Miller, Angela Pallotto, Christopher Koh, Beverly Niles, Jaha Norman, Huiman Barnhart, Matthew Baum, Jiezhun Gu, Yi‐Ju Li, Michelle McClanahan‐Crowder, Jeremy Mercer, Patricia Montana, Viviana Moreno, Eilene Pham, Hoss Rostami, Sheri Ussery, Kaye Williams, Stephanie Wu, Peter Hoffmann, Kidney Diseases, José Serrano, Jay Hoofnagle, Averell H. Sherker   +56 more
wiley   +1 more source

Metal Compound‐Based Non‐Enzymatic Electrochemical Cholesterol Sensors: Emerging Materials and Mechanistic Insights

Advanced Materials Interfaces, Volume 13, Issue 21, 6 November 2026.
This review discusses recent progress in metal complex‐based, non‐enzymatic electrochemical sensors for cholesterol detection. We examine metal oxides, metal sulfides, and hybrid nanomaterials, highlighting their catalytic mechanisms and material design strategies.
Longfei (Jack) Yin, Chao‐Tsen (Rora) Chen, Jacopo Giaretta, Thanh‐Qua Nguyen, Hoang‐Phuong Phan, Fariba Dehghani, Syamak Farajikhah   +6 more
wiley   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

When the Antibiogram Offers Nothing Else: Ceftriaxone–Sulbactam–Disodium EDTA With Intravenous Colistin in Two Neonates With Metallo‐β‐Lactamase‐Producing Acinetobacter baumannii Meningitis

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Two neonates with metallo‐β‐lactamase‐producing Acinetobacter baumannii meningitis, resistant to every tested alternative, received ceftriaxone–sulbactam–disodium EDTA plus intravenous colistin, which, to our knowledge, represents the first reported neonatal use of this combinations. Cultures were sterilized by day 7; both survived with normal
Naini Puri, Shantanu Shubham, Syed Moiz Ahmed, Richa Joshi, Divya Mishra, Hanshmani Prasad Chaudhary   +5 more
wiley   +1 more source