Results 81 to 90 of about 20,102 (177)

Physiological antioxidative network of the bilirubin system in aging and age-related diseases

Frontiers in Pharmacology, 2012
Oxidative stress is detrimental to life processes and is particularly responsible for aging and age-related diseases. Thus, most organisms are well equipped with a spectrum of biological defense mechanisms against oxidative stress.
Sung Young eKim, Sang Chul ePark
doaj   +1 more source

Specificity of biliverdin reductase [PDF]

Biochemical Journal, 1970
E, Colleran, P O, Carra
openaire   +2 more sources

Bile pigments in pulmonary and vascular disease

Frontiers in Pharmacology, 2012
The bile pigments, biliverdin and bilirubin, are endogenously-derived substances generated during enzymatic heme degradation. These compounds have been shown to act as chemical antioxidants in vitro. Bilirubin formed in tissues circulates in the serum,
Stefan W. Ryter
doaj   +1 more source

Pseudomonas aeruginosa heme metabolites biliverdin IXβ and IXδ are integral to lifestyle adaptations associated with chronic infection

mBio
Pseudomonas aeruginosa is a versatile opportunistic pathogen requiring iron for its survival and virulence within the host. The ability to switch to heme as an iron source and away from siderophore uptake provides an advantage in chronic infection.
Saba Shahzad, Samuel A. Krug, Susana Mouriño, Weiliang Huang, Maureen A. Kane, Angela Wilks   +5 more
doaj   +1 more source

Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines.

PLoS ONE, 2019
OBJECTIVE:Although previous studies have reported a negative relationship between serum bilirubin concentration and the development of diabetes mellitus (DM), the relationship between bilirubin and insulin resistance has not been thoroughly assessed ...
Ryoko Takei, Tomoaki Inoue, Noriyuki Sonoda, Motoyuki Kohjima, Misato Okamoto, Ryuichi Sakamoto, Toyoshi Inoguchi, Yoshihiro Ogawa   +7 more
doaj   +1 more source

Biliverdin [PDF]

, 2017
A. M. Gressner, O. A. Gressner
openaire   +2 more sources

Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout

Nature Communications
Performance of near-infrared probes and optogenetic tools derived from bacterial phytochromes is limited by availability of their biliverdin chromophore.
Ludmila A. Kasatkina, Chenshuo Ma, Huaxin Sheng, Matthew Lowerison, Luca Menozzi, Mikhail Baloban, Yuqi Tang, Yirui Xu, Lucas Humayun, Tri Vu, Pengfei Song, Junjie Yao, Vladislav V. Verkhusha   +12 more
doaj   +1 more source

Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Biomolecules
Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in ...
Bindu D. Paul, Andrew A. Pieper
doaj   +1 more source

Intracellular biliverdin dynamics during ferroptosis

The Journal of Biochemistry
Abstract Ferroptosis is a cell death mechanism mediated by iron-dependent lipid peroxidation. Although ferroptosis has garnered attention as a cancer-suppressing mechanism, there are still limited markers available for identifying ferroptotic cells or assessing their sensitivity to ferroptosis.
Kazuma Nakajima, Hironari Nishizawa, Guan Chen, Shunichi Tsuge, Mie Yamanaka, Machi Kiyohara, Riko Irikura, Mitsuyo Matsumoto, Kozo Tanaka, Rei Narikawa, Kazuhiko Igarashi   +10 more
openaire   +2 more sources

Biliverdin Reductase A [PDF]

, 2020
openaire   +1 more source