Results 1 to 10 of about 986,033 (238)
Current Research in Immunology, 2022 The antibody-binding Fc γ receptors (FcγRs) trigger life-saving immune responses and many therapeutic monoclonal antibodies require FcγR engagement for full effect. One proven strategy to improve the efficacy of antibody therapies is to increase receptor
Elizabeth A. Lampros +6 more
doaj +1 more source
Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies [PDF]
, 2012 Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy.
Abel, Tobias +5 more
core +10 more sources
mAbs, 2020 LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81
Karl J. M. Hanf +14 more
doaj +1 more source
Microbiology Spectrum, 2021 The rapid worldwide spread of SARS-CoV-2 has accelerated research and development for controlling the COVID-19 pandemic. A multi-coronavirus protein microarray was created containing full-length proteins, overlapping protein fragments of various lengths,
David Camerini +22 more
doaj +1 more source
Scientific Reports, 2021 Nervous necrosis virus (NNV) is a pathogenic fish-virus belonging to the genus Betanodavirus (Nodaviridae). Surface protrusions on NNV particles play a crucial role in both antigenicity and infectivity.
Hyun Jung Gye, Toyohiko Nishizawa
doaj +1 more source
Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin. [PDF]
PLoS ONE, 2011 Antigenic drift allowing escape from neutralizing antibodies is an important feature of transmission and survival of influenza viruses in host populations.
E Jane Homan, Robert D Bremel
doaj +1 more source
PLoS Pathogens, 2022 Exposure histories to SARS-CoV-2 variants and vaccinations will shape the specificity of antibody responses. To understand the specificity of Delta-elicited antibody immunity, we characterize the polyclonal antibody response elicited by primary or mRNA ...
Allison J Greaney +10 more
doaj +1 more source
Few and Far Between: How HIV May Be Evading Antibody Avidity [PDF]
, 2010 No ...
Bjorkman, Pamela J., Klein, Joshua S.
core +7 more sources
GII.4 Human Norovirus: Surveying the Antigenic Landscape
Viruses, 2019 Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden, with 685 million infections reported annually. Vulnerable populations, such as children under the age of 5 years, the immunocompromised, and the elderly show a need
Michael L. Mallory +3 more
doaj +1 more source
Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development. [PDF]
PLoS Pathogens, 2013 Glycan masking is an emerging vaccine design strategy to focus antibody responses to specific epitopes, but it has mostly been evaluated on the already heavily glycosylated HIV gp120 envelope glycoprotein.
Sowmya Sampath +9 more
doaj +1 more source