Results 1 to 10 of about 656,251 (149)
Structural consensus among antibodies defines the antigen binding site. [PDF]
PLoS Computational Biology, 2012 The Complementarity Determining Regions (CDRs) of antibodies are assumed to account for the antigen recognition and binding and thus to contain also the antigen binding site.
Vered Kunik, Bjoern Peters, Yanay Ofran
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Current Research in Immunology, 2022 The antibody-binding Fc γ receptors (FcγRs) trigger life-saving immune responses and many therapeutic monoclonal antibodies require FcγR engagement for full effect. One proven strategy to improve the efficacy of antibody therapies is to increase receptor
Elizabeth A. Lampros +6 more
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mAbs, 2020 LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81
Karl J. M. Hanf +14 more
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Scientific Reports, 2021 Nervous necrosis virus (NNV) is a pathogenic fish-virus belonging to the genus Betanodavirus (Nodaviridae). Surface protrusions on NNV particles play a crucial role in both antigenicity and infectivity.
Hyun Jung Gye, Toyohiko Nishizawa
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Microbiology Spectrum, 2021 The rapid worldwide spread of SARS-CoV-2 has accelerated research and development for controlling the COVID-19 pandemic. A multi-coronavirus protein microarray was created containing full-length proteins, overlapping protein fragments of various lengths,
David Camerini +22 more
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Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin. [PDF]
PLoS ONE, 2011 Antigenic drift allowing escape from neutralizing antibodies is an important feature of transmission and survival of influenza viruses in host populations.
E Jane Homan, Robert D Bremel
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PLoS Pathogens, 2022 Exposure histories to SARS-CoV-2 variants and vaccinations will shape the specificity of antibody responses. To understand the specificity of Delta-elicited antibody immunity, we characterize the polyclonal antibody response elicited by primary or mRNA ...
Allison J Greaney +10 more
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A comparison of the binding sites of antibodies and single-domain antibodies
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity. Antibodies (Abs) and single-domain antibodies (sdAbs) differ in the structures of their binding sites: most significantly, single-domain antibodies lack a light chain and
Gemma L. Gordon +5 more
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GII.4 Human Norovirus: Surveying the Antigenic Landscape
Viruses, 2019 Human norovirus is the leading cause of viral acute onset gastroenteritis disease burden, with 685 million infections reported annually. Vulnerable populations, such as children under the age of 5 years, the immunocompromised, and the elderly show a need
Michael L. Mallory +3 more
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Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development. [PDF]
PLoS Pathogens, 2013 Glycan masking is an emerging vaccine design strategy to focus antibody responses to specific epitopes, but it has mostly been evaluated on the already heavily glycosylated HIV gp120 envelope glycoprotein.
Sowmya Sampath +9 more
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