Results 11 to 20 of about 1,402,076 (343)
Pharmaceuticals, 2021 Treatment of neuroendocrine tumours with the radiolabelled somatostatin receptor subtype 2 (SST2) peptide agonist [177Lu]Lu-DOTA-TATE is effective and well-established.
Rosalba Mansi +3 more
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Toxins, 2021 Cobra venoms contain three-finger toxins (TFT) including α-neurotoxins efficiently binding nicotinic acetylcholine receptors (nAChRs). As shown recently, several TFTs block GABAA receptors (GABAARs) with different efficacy, an important role of the TFTs ...
Lina Son +7 more
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Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2
Computational and Structural Biotechnology Journal, 2014 We have shown earlier that Kir2 channels are suppressed by the elevation of membrane cholesterol. Moreover, it is also well known that activation of Kir channels is critically dependent on a regulatory phospholipid, phosphatidylinositol-4,5-bisphosphate (
Avia Rosenhouse-Dantsker +2 more
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Discovery and information-theoretic characterization of transcription factor binding sites that act cooperatively [PDF]
Physical Biology 12 (2015) 056004, 2015 Transcription factor binding to the surface of DNA regulatory regions is one of the primary causes of regulating gene expression levels. A probabilistic approach to model protein-DNA interactions at the sequence level is through Position Weight Matrices (PWMs) that estimate the joint probability of a DNA binding site sequence by assuming positional ...
arxiv +1 more source
Structural flexibility of intrinsically disordered proteins induces stepwise target recognition [PDF]
J. Chem. Phys. 139, 225103 (2013), 2013 An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outside, and intermediate states are observed in their binding processes.
arxiv +1 more source
Diversity of molecular targets and signaling pathways for CBD
Pharmacology Research & Perspectives, 2020 Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct from Δ9‐tetrahydrocannabinol (THC). Many studies that examined the behavioral effects of CBD concluded that it lacks the psychotomimetic ...
Douglas L. deAlmeida, Lakshmi A. Devi
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Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression [PDF]
Phys. Rev. E 95, 042412 (2017), 2016 Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters.
arxiv +1 more source
Data of protein-RNA binding sites
Data in Brief, 2017 Despite the increasing number of protein-RNA complexes in structure databases, few data resources have been made available which can be readily used in developing or testing a method for predicting either protein-binding sites in RNA sequences or RNA ...
Wook Lee +3 more
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Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands
Molecules, 2018 Dipeptidyl peptidase-4 (DPP-4) is a target to treat type II diabetes mellitus. Therefore, it is important to understand the structural aspects of this enzyme and its interaction with drug candidates.
Simone Queiroz Pantaleão +7 more
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Antibodies, 2020 Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya +11 more
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