Results 31 to 40 of about 322,466 (259)

Outer Membrane Vesicles from Acinetobacter baumannii: Biogenesis, Functions, and Vaccine Application

Vaccines, 2023
This review focuses on Acinetobacter baumannii, a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in A. baumannii that
Zheqi Weng, Ning Yang, Shujun Shi, Zining Xu, Zixu Chen, Chen Liang, Xiuwei Zhang, Xingran Du   +7 more
doaj   +1 more source

Endoplasmic Reticulum Membrane and Contact Site Dynamics in Autophagy Regulation and Stress Response

Frontiers in Cell and Developmental Biology, 2020
Autophagy mobilizes a variety of intracellular endomembranes to ensure a proper stress response and the maintenance of cellular homeostasis. While the process of de novo biogenesis of pre-autophagic structures is not yet fully characterized, the role of ...
Etienne Morel
doaj   +1 more source

A study of mitochondrial biogenesis in the rodent nervous system [PDF]

, 2015
This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The dynamics and functional impact of tRNA repertoires during early embryogenesis in zebrafish

The EMBO Journal
Embryogenesis entails dramatic shifts in mRNA translation and turnover that reprogram gene expression during cellular proliferation and differentiation.
Madalena M Reimão-Pinto, Andrew Behrens, Sergio Forcelloni, Klemens Fröhlich, Selay Kaya, Danny D Nedialkova   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2

BMC Genomics
Background The Y-linked mouse zinc finger genes Zfy1 and Zfy2 are critical fertility factors in mice but the mechanisms by which they regulate spermatogenesis remain unclear.
Hayden Holmlund, Yasuhiro Yamauchi, Muhammetnur Tekayev, Sydney Jakobs, Antoine Robin, Wataru Fujii, Monika A. Ward   +6 more
doaj   +1 more source

Platelet bioreactor: accelerated evolution of design and manufacture

Platelets, 2017
Platelets, responsible for clot formation and blood vessel repair, are produced by megakaryocytes in the bone marrow. Platelets are critical for hemostasis and wound healing, and are often provided following surgery, chemotherapy, and major trauma ...
Jonathan N. Thon, Brad J. Dykstra, Lea M. Beaulieu   +2 more
doaj   +1 more source

Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis

, 2011
Purpose: Exercise increases the production of reactive oxygen species (ROS) in skeletal muscle, and athletes often consume antioxidant supplements in the belief they will attenuate ROS-related muscle damage and fatigue during exercise.
AYA MATSUMOTO, SUSAN A. MARSH, Matsumoto, Aya, JONATHAN M. PEAKE, JEFF S. COOMBES, Wadley, Glenn, GLENN D. WADLEY, Strobel, Natalie, Peake, Jonathan, Marsh, Susan, Coombes, Jeff S., NATALIE A. STROBEL   +11 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source