Results 31 to 40 of about 12,509 (114)

CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2

BMC Genomics
Background The Y-linked mouse zinc finger genes Zfy1 and Zfy2 are critical fertility factors in mice but the mechanisms by which they regulate spermatogenesis remain unclear.
Hayden Holmlund, Yasuhiro Yamauchi, Muhammetnur Tekayev, Sydney Jakobs, Antoine Robin, Wataru Fujii, Monika A. Ward   +6 more
doaj   +1 more source

The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer

Frontiers in Immunology, 2020
The exosome serves as a trafficking vehicle for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells by exosomal PD-L1.
Yanyan Tang, Yanyan Tang, Yanyan Tang, Ping Zhang, Ping Zhang, Yumin Wang, Jinpeng Wang, Jinpeng Wang, Min Su, Min Su, Ying Wang, Ying Wang, Lianqing Zhou, Jumei Zhou, Jumei Zhou, Wei Xiong, Wei Xiong, Zhaoyang Zeng, Zhaoyang Zeng, Yujuan Zhou, Shaolin Nie, Shaolin Nie, Qianjin Liao, Qianjin Liao   +23 more
doaj   +1 more source

Identification, biogenesis, function, and mechanism of action of circular RNAs in plants

Plant Communications, 2023
Circular RNAs (circRNAs) are a class of single-stranded, closed RNA molecules with unique functions that are ubiquitously expressed in all eukaryotes.
Ruiqi Liu, Yu Ma, Tao Guo, Guanglin Li
doaj   +1 more source

CircRNA: A new class of targets for gastric cancer drug resistance therapy

Pathology and Oncology Research, 2023
Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and ...
Ying Zheng, Ying Zheng, Ying Zheng, Zhe Li, Zhe Li, Yao Wang, Yao Wang, Yao Wang, Wanjiao Chen, Yifan Lin, Yifan Lin, Junming Guo, Junming Guo, Junming Guo, Guoliang Ye, Guoliang Ye   +15 more
doaj   +1 more source

Lead Compounds in the Context of Extracellular Vesicle Research

Pharmaceutics, 2020
Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications.
Thao T.D. Tran, Phuong H.L. Tran
doaj   +1 more source

Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers

Molecular Therapy: Nucleic Acids, 2021
Circular RNAs (circRNAs) are covalently closed circular structures that can function in various physiological and pathological processes by acting as microRNA (miRNA) sponges, RNA-binding protein (RBP) sponges, mRNA transcriptional regulators, and ...
Lei Zhang, Yin Wang, Yuan Zhang, Yanfang Zhao, Peifeng Li   +4 more
doaj   +1 more source

The Effect of High-Intensity Interval Training on Mitochondrial-Associated Indices in Overweight and Obese Adults: A Systematic Review and Meta-Analysis

Frontiers in Bioscience-Landmark, 2023
Background: Obesity is a significant health problem with an increasing incidence, causing a low-grade systemic inflammatory state and being implicated in various chronic diseases.
Spyridon Hadjispyrou, Petros C Dinas, Spyridon Marios Delitheos, Ioannis-Alexios Koumprentziotis, Costas Chryssanthopoulos, Anastassios Philippou   +5 more
doaj   +1 more source

Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer

Cell Reports, 2017
The Get1/2 transmembrane complex drives the insertion of tail-anchored (TA) proteins from the cytosolic chaperone Get3 into the endoplasmic reticulum membrane.
Benjamin E. Zalisko, Charlene Chan, Vladimir Denic, Ronald S. Rock, Robert J. Keenan   +4 more
doaj   +1 more source

Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications

Membranes, 2022
Extracellular vesicles (EVs) are nanoscale membrane vesicles released by donor cells that can be taken up by recipient cells. The study of EVs has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and ...
Shenmin Xie, Qin Zhang, Li Jiang
doaj   +1 more source

Current Studies of Mitochondrial Quality Control in the Preeclampsia

Frontiers in Cardiovascular Medicine, 2022
Mitochondria are cellular energy powerhouses that play important roles in regulating cellular processes. Mitochondrial quality control (mQC), including mitochondrial biogenesis, mitophagy, mitochondrial fusion and fission, maintains physiological demand ...
Xiaoqing Peng, Xiaoqing Peng, Xiaoqing Peng, Xiaoqing Peng, Ruirui Hou, Ruirui Hou, Yuanyuan Yang, Zhigang Luo, Yunxia Cao, Yunxia Cao   +9 more
doaj   +1 more source