Results 41 to 50 of about 12,509 (114)

Bacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate

EMBO Reports
The chemical composition of membrane lipids differs between eukarya, bacteria and archaea. The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea.
Philipp Rieche, Mirthe Hoekzema, Sergiy Gan, Greetje A Berrelkamp-Lahpor, Adanna W Ezissi, Marten Exterkate, Arnold J M Driessen   +6 more
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GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome

Nature Communications
The bacterial chaperonin GroEL/ES promotes protein folding post-translation by transiently encapsulating client proteins within a central chamber. GroEL also binds translating ribosomes in vivo, implying an additional role in cotranslational folding ...
Alžběta Roeselová, Sarah L. Maslen, Jessica Zhiyun He, Gabija Jurkeviciute, Aleksandra Pajak, J. Mark Skehel, Radoslav I. Enchev, David Balchin   +7 more
doaj   +1 more source

Pre-Conception Maternal Obesity Confers Autism Spectrum Disorder-like Behaviors in Mice Offspring Through Neuroepigenetic Dysregulation

Cells
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with early-life origins. Maternal obesity has been associated with increased ASD risk, yet the mechanisms and timing of susceptibility remain unclear.
Nina P. Allan, Amada Torres, Michael J. Corley, Brennan Y. Yamamoto, Chantell Balaan, Yasuhiro Yamauchi, Rafael Peres, Yujia Qin, Vedbar S. Khadka, Youping Deng, Monika A. Ward, Alika K. Maunakea   +11 more
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Arrdc4‐dependent extracellular vesicle biogenesis is required for sperm maturation

Journal of Extracellular Vesicles, 2021
Extracellular vesicles (EVs) are important players in cell to cell communication in reproductive systems. Notably, EVs have been found and characterized in the male reproductive tract, however, direct functional evidence for their importance in mediating
Natalie J. Foot, Macarena B. Gonzalez, Kelly Gembus, Pamali Fonseka, Jarrod J. Sandow, Thuy Tien Nguyen, Diana Tran, Andrew I. Webb, Suresh Mathivanan, Rebecca L. Robker, Sharad Kumar   +10 more
doaj   +1 more source

Functional characterisation of PREL-1 and PREL-3 proteins as putative intramitochondrial phospholipid transporters governing homeostasis and organismal health in Caenorhabditis elegans

Frontiers in Molecular Biosciences
IntroductionMitochondrial phospholipids are crucial for maintaining structure and function; however, their roles and transport pathways are not fully understood in a multicellular model organism.
Vijay Aditya Mavuduru, Lavanya Vadupu, Kiruthiga Shankar Kumar, Naga Bhushana Rao Karampudi, Writoban Basu Ball   +4 more
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Circular RNAs—The Road Less Traveled

Frontiers in Molecular Biosciences, 2020
Circular RNAs are the most recent addition in the non-coding RNA family, which has started to gain recognition after a decade of obscurity. The first couple of reports that emerged at the beginning of this decade and the amount of evidence that has ...
Ashirbad Guria, Priyanka Sharma, Sankar Natesan, Gopal Pandi   +3 more
doaj   +1 more source

Peroxisome Biogenesis Disorders

Translational Science of Rare Diseases, 2016
The peroxisome biogenesis disorders (PBD) are a heterogeneous group of autosomal recessive disorders in which peroxisome assembly is impaired, leading to deficiencies of peroxisomal enzymes, complex developmental sequelae and progressive disabilities.
Argyriou, Catherine, D’Agostino, Maria Daniela, Braverman, Nancy   +2 more
openaire   +3 more sources

SND3 is the membrane insertase within a distinct SEC61 translocon complex

Nature Communications
During the biogenesis of most eukaryotic integral membrane proteins (IMPs), transmembrane domains are inserted into the endoplasmic reticulum membrane by a dedicated insertase or the SEC61 translocon.
Tzu-Jing Yang, Saumyak Mukherjee, Julian D. Langer, Gerhard Hummer, Melanie A. McDowell   +4 more
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Characterization of Shigella virulence factor intracellular spread A (IcsA, or VirG) functional epitopes against S. flexneri 2a and S. sonnei invasion and adherence

Applied and Environmental Microbiology
There are no licensed vaccines against Shigella, a leading cause of children’s diarrhea and travelers’ diarrhea. To develop a cross-protective vaccine against heterogeneous Shigella species and serotypes, we attempted to apply an epitope- and structure ...
Aashwina Madhwal, Sai Simha Reddy Vakamalla, Siqi Li, Weiping Zhang   +3 more
doaj   +1 more source

Alcohol Modulates the Biogenesis and Composition of Microglia-Derived Exosomes

Biology, 2019
Exosomes are small extracellular vesicles that have emerged as an important tool for intercellular communication. In the central nervous system, exosomes can mediate glia and neuronal communication.
Brennetta J. Crenshaw, Sanjay Kumar, Courtnee’ R. Bell, Leandra B. Jones, Sparkle D. Williams, Sabita N. Saldanha, Sameer Joshi, Rajnish Sahu, Brian Sims, Qiana L. Matthews   +9 more
doaj   +1 more source