Lipid droplets and lipotoxicity during autophagy. [PDF]
, 2017 Lipid droplets (LDs) are neutral lipid storage organelles that provide a rapidly accessible source of fatty acids (FAs) for energy during periods of nutrient deprivation.
Nguyen, Truc, Olzmann, James
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Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs. [PDF]
, 2017 Dicer enzymes process virus-specific double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) to initiate specific antiviral defense by related RNA interference (RNAi) pathways in plants, insects, nematodes, and mammals.
Gina Broitman-Maduro +10 more
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Platelet bioreactor: accelerated evolution of design and manufacture
Platelets, 2017 Platelets, responsible for clot formation and blood vessel repair, are produced by megakaryocytes in the bone marrow. Platelets are critical for hemostasis and wound healing, and are often provided following surgery, chemotherapy, and major trauma ...
Jonathan N. Thon +2 more
doaj +1 more source
The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production
Cell Reports, 2015 Polyadenylation of mRNA is a key step in eukaryotic gene expression. However, despite the major impact of poly(A) tails on mRNA metabolism, the precise roles of poly(A)-binding proteins (PABPs) in nuclear mRNA biogenesis remain elusive.
Manfred Schmid +5 more
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The genome and transcriptome of Trichormus sp NMC-1: insights into adaptation to extreme environments on the Qinghai-Tibet Plateau [PDF]
, 2016 The Qinghai-Tibet Plateau (QTP) has the highest biodiversity for an extreme environment worldwide, and provides an ideal natural laboratory to study adaptive evolution.
A Stamatakis +53 more
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The dynamics and functional impact of tRNA repertoires during early embryogenesis in zebrafish
The EMBO JournalEmbryogenesis entails dramatic shifts in mRNA translation and turnover that reprogram gene expression during cellular proliferation and differentiation.
Madalena M Reimão-Pinto +5 more
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The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer
Frontiers in Immunology, 2020 The exosome serves as a trafficking vehicle for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells by exosomal PD-L1.
Yanyan Tang +23 more
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Postconditioning with D-limonene exerts neuroprotection in rats via enhancing mitochondrial activity
Türk Biyokimya Dergisi, 2023 The key component of neuroprotection after cerebral ischemia–reperfusion (I–R) injury is mitochondrial improvement. By focusing on the function of mitochondrial biogenesis and ATP-sensitive potassium (mK–ATP) channels and inflammatory responses, the ...
Zhang Leguo +5 more
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CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2
BMC GenomicsBackground The Y-linked mouse zinc finger genes Zfy1 and Zfy2 are critical fertility factors in mice but the mechanisms by which they regulate spermatogenesis remain unclear.
Hayden Holmlund +6 more
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Identification, biogenesis, function, and mechanism of action of circular RNAs in plants
Plant Communications, 2023 Circular RNAs (circRNAs) are a class of single-stranded, closed RNA molecules with unique functions that are ubiquitously expressed in all eukaryotes.
Ruiqi Liu, Yu Ma, Tao Guo, Guanglin Li
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