Results 41 to 50 of about 290,493 (308)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The biogenesis of the immunopeptidome
Seminars in Immunology, 2023 The immunopeptidome is the repertoire of peptides bound and presented by the MHC class I, class II, and non-classical molecules. The peptides are produced by the degradation of most cellular proteins, and in some cases, peptides are produced from extracellular proteins taken up by the cells.
openaire +2 more sources
The Biogenesis and Functions of Exosomes [PDF]
Traffic, 2002 Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. They correspond to the internal vesicles of an endosomal compartment, the multivesicular body and are released upon exocytic fusion of this organelle with the plasma membrane. Intracellularly, they are formed by inward budding
Stoorvogel, Willem +3 more
openaire +3 more sources
The dynamics and functional impact of tRNA repertoires during early embryogenesis in zebrafish
The EMBO JournalEmbryogenesis entails dramatic shifts in mRNA translation and turnover that reprogram gene expression during cellular proliferation and differentiation.
Madalena M Reimão-Pinto +5 more
doaj +1 more source
CircRNA: A new class of targets for gastric cancer drug resistance therapy
Pathology and Oncology Research, 2023 Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and ...
Ying Zheng +15 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2
BMC GenomicsBackground The Y-linked mouse zinc finger genes Zfy1 and Zfy2 are critical fertility factors in mice but the mechanisms by which they regulate spermatogenesis remain unclear.
Hayden Holmlund +6 more
doaj +1 more source
Lead Compounds in the Context of Extracellular Vesicle Research
Pharmaceutics, 2020 Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications.
Thao T.D. Tran, Phuong H.L. Tran
doaj +1 more source
Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers
Molecular Therapy: Nucleic Acids, 2021 Circular RNAs (circRNAs) are covalently closed circular structures that can function in various physiological and pathological processes by acting as microRNA (miRNA) sponges, RNA-binding protein (RBP) sponges, mRNA transcriptional regulators, and ...
Lei Zhang +4 more
doaj +1 more source
A comparative study of peroxisomal structures in Hansenula polymorpha pex mutants [PDF]
, 2007 In a recent study, we performed a systematic genome analysis for the conservation of genes involved in peroxisome biogenesis (PEX genes) in various fungi.
Koek, Anne, +8 more
core +1 more source