Results 51 to 60 of about 431,520 (211)
Lead Compounds in the Context of Extracellular Vesicle Research
Pharmaceutics, 2020 Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications.
Thao T.D. Tran, Phuong H.L. Tran
doaj +1 more source
CircRNA: A new class of targets for gastric cancer drug resistance therapy
Pathology and Oncology Research, 2023 Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and ...
Ying Zheng +15 more
doaj +1 more source
Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif +2 more
core +3 more sources
Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers
Molecular Therapy: Nucleic Acids, 2021 Circular RNAs (circRNAs) are covalently closed circular structures that can function in various physiological and pathological processes by acting as microRNA (miRNA) sponges, RNA-binding protein (RBP) sponges, mRNA transcriptional regulators, and ...
Lei Zhang +4 more
doaj +1 more source
Biogenesis of cytochrome c1 [PDF]
, 1989 The biogenesis of cytochrome c1 involves a number of steps including: synthesis as a precursor with a bipartite signal sequence, transfer across the outer and inner mitochondrial membranes, removal of the first part of the presequence in the matrix ...
Neupert, Walter +2 more
core
Peroxisome biogenesis and peroxisome biogenesis disorders
FEBS Letters, 2000 Peroxisome assembly in mammals requires more than 15 genes. Two isoforms of the peroxisome targeting signal type 1 (PTS1) receptor, Pex5pS and Pex5pL, are identified in mammals. Pex5pS and Pex5pL bind PTS1 proteins. Pex5pL, but not Pex5pS, directly interacts with the PTS2 receptor, Pex7p, carrying its cargo PTS2 protein in the cytosol.
openaire +2 more sources
Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer
Cell Reports, 2017 The Get1/2 transmembrane complex drives the insertion of tail-anchored (TA) proteins from the cytosolic chaperone Get3 into the endoplasmic reticulum membrane.
Benjamin E. Zalisko +4 more
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Frontiers in Bioscience-Landmark, 2023 Background: Obesity is a significant health problem with an increasing incidence, causing a low-grade systemic inflammatory state and being implicated in various chronic diseases.
Spyridon Hadjispyrou +5 more
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Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications
Membranes, 2022 Extracellular vesicles (EVs) are nanoscale membrane vesicles released by donor cells that can be taken up by recipient cells. The study of EVs has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and ...
Shenmin Xie, Qin Zhang, Li Jiang
doaj +1 more source
Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]
, 2016 Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F. +4 more
core +1 more source