Results 61 to 70 of about 322,466 (259)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Bacterial lipid synthesizing enzymes PlsY and PlsC utilize both stereo-forms of glycerol-phosphate

EMBO Reports
The chemical composition of membrane lipids differs between eukarya, bacteria and archaea. The central dogma posits that the stereochemistry of phospholipids in bacteria is distinct from archaea.
Philipp Rieche, Mirthe Hoekzema, Sergiy Gan, Greetje A Berrelkamp-Lahpor, Adanna W Ezissi, Marten Exterkate, Arnold J M Driessen   +6 more
doaj   +1 more source

Mode of miRNA biogenesis matters

, 2015
Mode of miRNA biogenesis ...
Vaucheret, Hervé
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome

Nature Communications
The bacterial chaperonin GroEL/ES promotes protein folding post-translation by transiently encapsulating client proteins within a central chamber. GroEL also binds translating ribosomes in vivo, implying an additional role in cotranslational folding ...
Alžběta Roeselová, Sarah L. Maslen, Jessica Zhiyun He, Gabija Jurkeviciute, Aleksandra Pajak, J. Mark Skehel, Radoslav I. Enchev, David Balchin   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Integration of mitochondrial biogenesis through parameter fitting.

, 2017
(A) Schematic representation of mitochondrial fusion, fission and biogenesis events. Biogenesis is represented by frequency (Bf) and probability (Bp) parameters, and can occur in all mitochondria with a mass less than Mmax = 3.0 μm2. (B) Basic flow chart
Nathan Ryan Brady (3621800), Paula Andrea Marin Zapata (3621803), Anne Hamacher-Brady (177723), Giovanni Dalmasso (3521870)   +3 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]

, 2012
Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Sharma, Sunny, Watzinger, Peter, Lamberth, Stefanie, Entian, Karl-Dieter, Kötter, Peter, Peifer, Christian   +5 more
core   +1 more source

Pipeline to quantify ribosome biogenesis activity

, 2023
Pipeline to quantify ribosome biogenesis activity based on transcriptome expression ...
Huajing Teng (17220052)
core   +1 more source