Results 81 to 90 of about 322,466 (259)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Characterization of Shigella virulence factor intracellular spread A (IcsA, or VirG) functional epitopes against S. flexneri 2a and S. sonnei invasion and adherence

Applied and Environmental Microbiology
There are no licensed vaccines against Shigella, a leading cause of children’s diarrhea and travelers’ diarrhea. To develop a cross-protective vaccine against heterogeneous Shigella species and serotypes, we attempted to apply an epitope- and structure ...
Aashwina Madhwal, Sai Simha Reddy Vakamalla, Siqi Li, Weiping Zhang   +3 more
doaj   +1 more source

Alcohol Modulates the Biogenesis and Composition of Microglia-Derived Exosomes

Biology, 2019
Exosomes are small extracellular vesicles that have emerged as an important tool for intercellular communication. In the central nervous system, exosomes can mediate glia and neuronal communication.
Brennetta J. Crenshaw, Sanjay Kumar, Courtnee’ R. Bell, Leandra B. Jones, Sparkle D. Williams, Sabita N. Saldanha, Sameer Joshi, Rajnish Sahu, Brian Sims, Qiana L. Matthews   +9 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

SND3 is the membrane insertase within a distinct SEC61 translocon complex

Nature Communications
During the biogenesis of most eukaryotic integral membrane proteins (IMPs), transmembrane domains are inserted into the endoplasmic reticulum membrane by a dedicated insertase or the SEC61 translocon.
Tzu-Jing Yang, Saumyak Mukherjee, Julian D. Langer, Gerhard Hummer, Melanie A. McDowell   +4 more
doaj   +1 more source

Regulatory roles of circular RNAs in poultry diseases: mechanisms and research advances

Frontiers in Veterinary Science
Research on circular RNA (circRNA) in poultry increasingly explores its role as a potential regulator in various diseases. It has also shown differential expression of circRNAs in infected tissues, signifying their participation in disease pathogenesis ...
Sumayya, Hassan A. Rudayni, Muhammad Shuaib, Bichun Li, Hongyan Sun, Obaid Ullah, Abdullah S. Alawam, Ahmed A. Allam, Ahmed A. Elolimy, Mohamed E. Abd El-Hack   +9 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Does RAB31 Continue to Play a Role in Exosome Biogenesis of Adipose-Derived Mesenchymal Stem Cells in 2D and 3D Culture Conditions in a Hypoxic Environment?

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Mesenchymal stem cells (MSCs) are considered potential candidates in regenerative medicine due to their angiogenic, anti-apoptotic, and immunomodulatory properties. Among the secretory products of MSCs are biomolecules such as cytokines,
Hafize Seda Vatansever, Hilal Kabadayı Ensarioğlu, Aslınur Aktaş, Burak Kutlu Aydın, Nadire Kıyak, Mehmet Vatansever   +5 more
doaj   +1 more source

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

The Val66Met variant of brain-derived neurotrophic factor is linked to reduced telomere length in a military population: a pilot study

Scientific Reports
In military populations, gene-environment interactions can influence performance and health outcomes. Brain-derived neurotrophic factor (BDNF) is a central nervous system protein that is important for neuronal function and synaptic plasticity.
Richard C. Allsopp, Lisa M. Hernández, Marcus K. Taylor   +2 more
doaj   +1 more source