Results 1 to 10 of about 311,632 (269)

ADVANCING THE METHODOLOGY OF TEACHING BIOLOGICAL SCIENCES BASED ON THE ORGANIZATION OF RESEARCH ACTIVITIES OF STUDENTS

Farabi Journal of Social Sciences, 2022
Malika I. Khamdamova
openaire   +3 more sources

Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy

iScience, 2022
Summary: Although optical microscopy has allowed scientists to study the entire brain in early developmental stages, access to the brains of live, adult vertebrates has been limited.
Najva Akbari, Rose L. Tatarsky, Kristine E. Kolkman, Joseph R. Fetcho, Andrew H. Bass, Chris Xu   +5 more
doaj   +1 more source

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

iScience, 2022
Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou, David Hou, Cristina Cusco Marigo, Joaquín Bonelli, Pau Rocas, Fangzhou Cheng, Xiaoqiu Yang, Josep Rocas, Naomi M. Hamberg, Jingyan Han   +9 more
doaj   +1 more source

The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases

iScience, 2023
Summary: RNA-binding protein with multiple splicing (RBPMS) plays a crucial role in cardiac mesoderm specification and cardiovascular development, as well as being a typical marker for whole retinal ganglion cells (RGCs).
Guilan Li, Yuanting Luo, Qikai Zhang, Wenfei Chen, Kunbei Lai, Yizhi Liu, Yingfeng Zheng   +6 more
doaj   +1 more source

Circulating tumor cells: Towards mechanical phenotyping of metastasis

iScience, 2022
Summary: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain ...
Marina Peralta, Naël Osmani, Jacky G. Goetz   +2 more
doaj   +1 more source

A method for investigating spatiotemporal growth patterns at cell and tissue levels during C-looping in the embryonic chick heart

iScience, 2022
Summary: We developed a workflow using multi-scale and multi-disciplinary experimental and computational approaches to analyze C-looping (the first phase of cardiac looping) of the chick across four developing hearts. We provide the first 3D datasets for
Nazanin Ebrahimi, Mahyar Osanlouy, Chris P. Bradley, M. Fabiana Kubke, Dane A. Gerneke, Peter J. Hunter   +5 more
doaj   +1 more source

Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface

iScience, 2022
Summary: Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation
Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F.C.C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt, Michael Eikmans   +18 more
doaj   +1 more source

Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures

iScience, 2022
Summary: The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling.
Adam T. Szafran, Maureen G. Mancini, Fabio Stossi, Michael A. Mancini   +3 more
doaj   +1 more source

Development of an in vivo system to model breast cancer metastatic organotropism and evaluate treatment response using the chick embryo

iScience, 2023
Summary: Metastatic lesions produced through the process of systemic tumor cell dissemination and growth at distant sites are challenging to treat and the primary cause of patient mortality.
Sumreen Javed, Sepideh Soukhtehzari, Nikki Salmond, Nazarine Fernandes, Karla C. Williams   +4 more
doaj   +1 more source

Influence of data sampling methods on the representation of neural spiking activity in vivo

iScience, 2022
Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden, Amanda M. Brown, Roy V. Sillitoe   +2 more
doaj   +1 more source