Results 1 to 10 of about 317,941 (266)

Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy

iScience, 2022
Summary: Although optical microscopy has allowed scientists to study the entire brain in early developmental stages, access to the brains of live, adult vertebrates has been limited.
Najva Akbari, Rose L. Tatarsky, Kristine E. Kolkman, Joseph R. Fetcho, Andrew H. Bass, Chris Xu   +5 more
doaj   +1 more source

Methodologies, technologies, and strategies for acoustic streaming-based acoustofluidics

Applied Physics Reviews, 2023
Acoustofluidics offers contact-free manipulation of particles and fluids, enabling their uses in various life sciences, such as for biological and medical applications.
Mercedes Stringer, Ziming Zeng, Xiaoyan Zhang, Yanyan Chai, Wen Li, Jikai Zhang, Huiling Ong, Dongfang Liang, Jing Dong, Yiming Li, Yongqing Fu, Xin Yang   +11 more
semanticscholar   +1 more source

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

iScience, 2022
Summary: Aortic endothelial cell dysfunction is an early trigger of atherosclerosis, the major cause of the cardiovascular disease (CVD). Nanomedicines targeting vascular endothelium and lesions hold great promise as therapeutic solutions to vascular ...
Yuxiang Zhou, David Hou, Cristina Cusco Marigo, Joaquín Bonelli, Pau Rocas, Fangzhou Cheng, Xiaoqiu Yang, Josep Rocas, Naomi M. Hamberg, Jingyan Han   +9 more
doaj   +1 more source

A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research

International Journal of Molecular Sciences, 2021
Recent advances in sequencing and biotechnological methodologies have led to the generation of large volumes of molecular data of different omics layers, such as genomics, transcriptomics, proteomics and metabolomics.
E. Vlachavas, Jonas Bohn, F. Ückert, Sylvia Nürnberg   +3 more
semanticscholar   +1 more source

Circulating tumor cells: Towards mechanical phenotyping of metastasis

iScience, 2022
Summary: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain ...
Marina Peralta, Naël Osmani, Jacky G. Goetz   +2 more
doaj   +1 more source

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

International Journal of Molecular Sciences, 2021
Recent advances in the synthesis of metal nanoparticles (MeNPs), and more specifically gold nanoparticles (AuNPs), have led to tremendous expansion of their potential applications in different fields, ranging from healthcare research to microelectronics ...
M. Kus-Liśkiewicz, P. Fickers, I. Ben Tahar   +2 more
semanticscholar   +1 more source

The RBPMSCreERT2-tdTomato mouse line for studying retinal and vascular relevant diseases

iScience, 2023
Summary: RNA-binding protein with multiple splicing (RBPMS) plays a crucial role in cardiac mesoderm specification and cardiovascular development, as well as being a typical marker for whole retinal ganglion cells (RGCs).
Guilan Li, Yuanting Luo, Qikai Zhang, Wenfei Chen, Kunbei Lai, Yizhi Liu, Yingfeng Zheng   +6 more
doaj   +1 more source

A method for investigating spatiotemporal growth patterns at cell and tissue levels during C-looping in the embryonic chick heart

iScience, 2022
Summary: We developed a workflow using multi-scale and multi-disciplinary experimental and computational approaches to analyze C-looping (the first phase of cardiac looping) of the chick across four developing hearts. We provide the first 3D datasets for
Nazanin Ebrahimi, Mahyar Osanlouy, Chris P. Bradley, M. Fabiana Kubke, Dane A. Gerneke, Peter J. Hunter   +5 more
doaj   +1 more source

Advances in experimental and computational methodologies for the study of microbial-surface interactions at different omics levels

Frontiers in Microbiology, 2022
The study of the biological response of microbial cells interacting with natural and synthetic interfaces has acquired a new dimension with the development and constant progress of advanced omics technologies. New methods allow the isolation and analysis
J. J. González-Plaza, Cristina Furlan, Tomaž Rijavec, A. Lapanje, R. Barros, J. A. Tamayo-Ramos, M. Suárez-Diez   +6 more
semanticscholar   +1 more source

Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface

iScience, 2022
Summary: Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation
Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F.C.C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt, Michael Eikmans   +18 more
doaj   +1 more source