Results 211 to 220 of about 17,092 (277)
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Nature Nanotechnology, 2021
Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes.
Zhaowei Chen +15 more
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Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes.
Zhaowei Chen +15 more
openaire +2 more sources
Boronic Acids as Bioorthogonal Probes for Site-Selective Labeling of Proteins [PDF]
Angewandte Chemie - International Edition, 2018 Over the past two decades, bioorthogonal chemistry has become a preferred tool to achieve site‐selective modifications of proteins. However, there are only a handful of commonly applied bioorthogonal reactions and they display some limitations, such as ...
Dennis G. Hall
exaly +2 more sources
Orthogonal bioorthogonal chemistries
Current Opinion in Chemical Biology, 2015Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable bioorthogonal chemistries, but also combinations of reactions that can be used in tandem. Such 'orthogonal bioorthogonal' transformations have been reported in recent years, and these chemistries
David M, Patterson, Jennifer A, Prescher
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Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions [PDF]
Angewandte Chemie - International Edition, 2023 Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool to perform novel biocompatible chemospecific reactions in living systems.
Ana Sousa-Castillo +2 more
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Bioorthogonal Ligation in the Spotlight
Angewandte Chemie International Edition, 2009AbstractThe light‐induced formation of a covalent bond between an alkene group and a tetrazole moiety has been used for the selective labeling of proteins in vitro and in live cells. This bioorthogonal ligation initiated by brief irradiation with UV light leads to a fluorescent pyrazoline adduct (see scheme).magnified ...
Thomas, Kurpiers, Henning D, Mootz
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Dissociative Bioorthogonal Reactions
ChemBioChem, 2019AbstractBioorthogonal reactions that proceed readily under physiological conditions without interference from biomolecules have found widespread application in the life sciences. Complementary to the bioorthogonal reactions that ligate two molecules, reactions that release a molecule or cleave a linker are increasingly attracting interest.
Julian Tu +2 more
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Journal of the American Chemical Society
Covalent modification of cell membranes has shown promise for tumor imaging and therapy. However, existing membrane labeling techniques face challenges such as slow kinetics and poor selectivity for cancer cells, leading to off-target effects and ...
Yin-Xing Miao +16 more
semanticscholar +1 more source
Covalent modification of cell membranes has shown promise for tumor imaging and therapy. However, existing membrane labeling techniques face challenges such as slow kinetics and poor selectivity for cancer cells, leading to off-target effects and ...
Yin-Xing Miao +16 more
semanticscholar +1 more source
Journal of the American Chemical Society
Highly fluorogenic probe based bioorthogonal chemistry has become a promising tool in biomedical applications. However, the majority of fluorogenic probes are designed by introducing a bioorthogonal partner as a fluorescence quencher into classical ...
Li-Ping Wang +7 more
semanticscholar +1 more source
Highly fluorogenic probe based bioorthogonal chemistry has become a promising tool in biomedical applications. However, the majority of fluorogenic probes are designed by introducing a bioorthogonal partner as a fluorescence quencher into classical ...
Li-Ping Wang +7 more
semanticscholar +1 more source
Advances in Materials
Pyroptosis can trigger strong immunogenic cell death (ICD) of tumor cells for antitumor immunotherapy. However, metabolic disorders of fumarate in the tumor microenvironment (TME) can significantly reduce the pyroptosis rate and render T lymphocytes ...
Rui Niu +8 more
semanticscholar +1 more source
Pyroptosis can trigger strong immunogenic cell death (ICD) of tumor cells for antitumor immunotherapy. However, metabolic disorders of fumarate in the tumor microenvironment (TME) can significantly reduce the pyroptosis rate and render T lymphocytes ...
Rui Niu +8 more
semanticscholar +1 more source