Results 231 to 240 of about 17,092 (277)

Bioorthogonal Reactions for Labeling Proteins

ACS Chemical Biology, 2014
O the past 15 years a great deal of progress has been made on the discovery, rediscovery, and invention of bioorthogonal reactions between functional groups that do not react with biological entities under physiological conditions but selectively react with each other.
Kathrin, Lang, Jason W, Chin
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In Vivo Self-Assembly of PROTACs by Bioorthogonal Chemistry for Precision Cancer Therapy.

Angewandte Chemie
Proteolysis targeting chimeras (PROTACs) hold immense promise for targeted protein degradation; however, challenges such as off-target effects, poor drug-likeness properties, and the "hook effect" remain.
Shaowen Xie, Jingjie Zhu, Yihan Peng, Fang-Yi Zhan, Fei-Yan Zhan, Chen He, Da-Zhi Feng, Jia Xie, Jingyu Liu, Huajian Zhu, Hong Yao, Jin-Yi Xu, Zhigui Su, Sheng-Tao Xu   +13 more
semanticscholar   +1 more source

Building better bioorthogonal reactions

Current Opinion in Chemical Biology, 2014
Over the past two decades, there has been intense interest in designing and implementing selective (bioorthogonal) reactions for biomolecule tracking. Here we review the most widely used bioorthogonal chemistries in live cells and animals, drawing particular attention to the unique functional groups underlying these transformations.
Hui-Wen, Shih, David N, Kamber, Jennifer A, Prescher   +2 more
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Bioorthogonal/Ultrasound Activated Oncolytic Pyroptosis Amplifies In Situ Tumor Vaccination for Boosting Antitumor Immunity.

ACS Nano
Personalized in situ tumor vaccination is a promising immunotherapeutic modality. Currently, seeking immunogenic cell death (ICD) to generate in situ tumor vaccines is still mired by insufficient immunogenicity and an entrenched immunosuppressive tumor ...
Xiaoyu Xu, Jin-Ling Zheng, Na Liang, Xu Zhang, Shayibai Shabiti, Zixi Wang, Shi-Wen Yu, Zheng-Yin Pan, Wen-Jun Li, Lin-Tao Cai   +9 more
semanticscholar   +1 more source

Finding the Right (Bioorthogonal) Chemistry

ACS Chemical Biology, 2014
Bioorthogonal chemistries can be used to tag diverse classes of biomolecules in cells and other complex environments. With over 20 unique transformations now available, though, selecting an appropriate reaction for a given experiment is challenging.
David M, Patterson, Lidia A, Nazarova, Jennifer A, Prescher   +2 more
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Designer Nanoreactors for Bioorthogonal Catalysis

Accounts of Chemical Research
The evolutionary complexity of compartmentalized biostructures (such as cells and organelles) endows life-sustaining multistep chemical cascades and intricate living functionalities. Relatively, within a very short time span, a synthetic paradigm has resulted in tremendous growth in controlling the materials at different length scales (molecular, nano,
Amit Kumar, In Su Lee
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A Membrane-Anchoring Self-Assembling Peptide Allows Bioorthogonal Coupling of Type-I AIEgens for Pyroptosis-Induced Cancer Therapy.

Angewandte Chemie
Enrichment of photosensitizers (PSs) on cancer cell membranes via bioorthogonal reactions is considered to be a very promising therapeutic modality. However, azide-modified sugars-based metabolic labeling processes usually lack targeting and the labeling
Sheng-Lu Ji, Teng-Wu Pan, Kai-Yuan Wang, Weiqi Zai, Ru Jia, Nannan Wang, Shaorui Jia, Dan Ding, Yang Shi   +8 more
semanticscholar   +1 more source

Cell-selective bioorthogonal labeling

Cell Chemical Biology
In classic bioorthogonal labeling experiments, the cell's biosynthetic machinery incorporates bioorthogonal tags, creating tagged biomolecules that are subsequently reacted with a corresponding bioorthogonal partner. This two-step approach labels biomolecules throughout the organism indiscriminate of cell type, which can produce background in ...
Wei Huang, Scott T. Laughlin
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Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications.

Journal of Controlled Release
Bioorthogonal nanozymes have emerged as a potent tool in biomedicine due to their unique ability to perform enzymatic reactions that do not interfere with native biochemical processes. The integration of stimuli-responsive mechanisms into these nanozymes
Yan Zhang, Fang Lei, Wanlong Qian, Chengfeng Zhang, Qi Wang, Chaoqun Liu, Haiwei Ji, Zheng-Wei Liu, Faming Wang   +8 more
semanticscholar   +1 more source

Single-Atom Catalysts Mediated Bioorthogonal Modulation of N6-Methyladenosine Methylation for Boosting Cancer Immunotherapy.

Journal of the American Chemical Society
Bioorthogonal reactions provide a powerful tool to manipulate biological processes in their native environment. However, the transition-metal catalysts (TMCs) for bioorthogonal catalysis are limited to low atomic utilization and moderate catalytic ...
Mengyu Sun, Xuemeng Liu, Zhengwei Liu, Wenting Zhang, Guangming Li, Jin-Song Ren, Xiao-Gang Qu   +6 more
semanticscholar   +1 more source