Results 241 to 250 of about 17,092 (277)

Modular activatable bioorthogonal reagents

2019
The bioorthogonal reaction toolbox contains approximately two-dozen unique chemistries that permit selective tagging and probing of biomolecules. Over the past two decades, significant effort has been devoted to optimizing and discovering bioorthogonal reagents that are faster, fluorogenic, and orthogonal to the already existing bioorthogonal ...
Pratik, Kumar, Scott T, Laughlin
openaire   +2 more sources

In-Cell Association of a Bioorthogonal Tubulin

Biomacromolecules
Studies of proteins from one organism in another organism's cells have shown that such exogenous proteins stick more, pointing toward coevolution of the cytoplasm and protein surface to minimize stickiness. Here we flip this question around by asking whether exogenous proteins can assemble efficiently into their target complexes in a non-native ...
Yuhan Wang, Mahima Unnikrishnan, Brooke Ramsey, Driss El Andlosy, Alex T. Keeley, Catherine J. Murphy, Martin Gruebele   +6 more
openaire   +2 more sources

A Synergistic Chemoimmunotherapy System Leveraging PD‐L1 Blocking and Bioorthogonal Prodrug Activation

Advances in Materials
Novel strategies to facilitate tumor‐specific drug delivery and restore immune attacks remain challenging in overcoming the current limitations of chemoimmunotherapy.
Kewei Wang, Mao-lin Jiang, Tao Li, Ye Liu, Qingyu Zong, Qing Xu, I. Ullah, Ya-Hui Chen, Wei Xue, You-Yong Yuan   +9 more
semanticscholar   +1 more source

Applications of bioorthogonal reactions in bioimaging

Talanta
The rapid development of bioorthogonal chemistry in the preceding decade has enabled precise, specific, selective labelling and accurate modulation of biological processes in vivo. The ability of bioorthogonal chemistry to occur rapidly in a living system without interfering with native biochemical processes has shown great potential for a variety of ...
Weihua Zhuang, Yanfei Xu, Xiyong Zhuo, Tianfeng Xu, Wenhong Li, Shufen Li, Yongchao Yao, Feng Ye, Wenchuang Hu   +8 more
openaire   +2 more sources

Bioorthogonal Chemistry-Guided Inhalable Nanoprodrug to Circumvent Cisplatin Resistance in Orthotopic Nonsmall Cell Lung Cancer.

ACS Nano
Pulmonary delivery of anticancer therapeutics has shown encouraging performance in treating nonsmall cell lung cancer (NSCLC), which is characterized by high aggressiveness and poor prognosis.
Lu Tang, Yue Yin, Yuqi Cao, Hening Liu, Guang-Chao Qing, Cong Fu, Zixuan Li, Yuanbo Zhu, Weijie Shu, Shun He, Ji-Fan Gao, Yi Zhang, Zi-Han Wang, Jianlan Bu, Xuejing Li, Meng-Liang Zhu, Xing-Jie Liang, Wei Wang   +17 more
semanticscholar   +1 more source

Enzyme-Mediated Bioorthogonal Cascade Catalytic Reaction for Metabolism Intervention and Enhanced Ferroptosis on Neuroblastoma.

Journal of the American Chemical Society
It remains a tremendous challenge to explore effective therapeutic modalities against neuroblastoma, a lethal cancer of the sympathetic nervous system with poor prognosis and disappointing treatment outcomes.
Qi Wang, Xiang-Ze Li, Zhi-Yao Cao, Wei Feng, Yu Chen, Da-Peng Jiang   +5 more
semanticscholar   +1 more source

Tetrazine-Isonitrile Bioorthogonal Fluorogenic Reactions Enable Multiplex Labeling and Wash-Free Bioimaging of Live Cells.

Angewandte Chemie
Developing fluorogenic probes for simultaneous live cell labeling of multiple targets is crucial for understanding complex cellular events. The emerging [4+1] cycloaddition between tetrazine and isonitriles holds promise as a bioorthogonal tool, yet ...
Yingqiao Deng, Tian-Xiang Shen, Xinyu Yu, Jie Li, Peixuan Zou, Qiyong Gong, Yongxiang Zheng, Hong-Bao Sun, Xiao-Gang Liu, Haoxing Wu   +9 more
semanticscholar   +1 more source

A High-Efficiency Bioorthogonal Tumor-Membrane Reactor for In Situ Selective and Sustained Prodrug Activation.

Angewandte Chemie
The site-specific activation of bioorthogonal prodrugs has provided great opportunities for reducing the severe side effects of chemotherapy. However, the precise control of activation location, sustained drug production at the target site, and high ...
Yu Ma, Yun-Yun Zhou, Jia-Qin Long, Qi Sun, Zijiang Luo, Wen-Jie Wang, Ting Hou, Li Yin, Ling-Zhi Zhao, Juan-Juan Peng, Ya Ding   +10 more
semanticscholar   +1 more source

Nitric Oxide‐Activated Bioorthogonal Codelivery Nanoassembly for In Situ Synthesis of Photothermal Agent for Precise and Safe Anticancer Treatment

Advances in Materials
The development of bioorthogonal activation in drug release represents a promising avenue for precise and safe anticancer treatment. However, two significant limitations currently hinder their clinical application: i) the necessity for separate ...
Bo-Wen Li, Jian-Wu Tian, Chong-Zhi Wu, Zhi-Yao Li, Li Qiao, Zong-Liang Xie, Bo Song, Shan Yi, Siqin Chen, Yu-Fu Tang, Yuan Ping, Bin Liu   +11 more
semanticscholar   +1 more source

Bioorthogonal conjugation of probiotics for inflammatory bowel disease.

Journal of Controlled Release
Inflammatory bowel disease (IBD) is closely associated with dysregulated immune response, gut mucosal barrier, and microbiota. Conventional treatments suffer from inferior bioavailability and inadequate efficiency.
Pan-Di Peng, Tao Feng, Xue Yang, Rui Ding, Jun-Ru Wang, Pengyu Chen, Yuxin Guo, Peng Li   +7 more
semanticscholar   +1 more source