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Design strategies for tetrazine fluorogenic probes for bioorthogonal imaging.
Chemical Society ReviewsTetrazine fluorogenic probes play a critical role in bioorthogonal chemistry, selectively activating fluorescence upon reaction to enhance precision in imaging and sensing within complex biological environments.
A. Yu +7 more
semanticscholar +1 more source
Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications
Advanced MaterialsBioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology in recent years, bioorthogonal nanozymes are innovated to tackle the challenges that emerged
Jinsong Ren, Xiaogang Qu
exaly +2 more sources
On-Membrane Supramolecular Assemblies Serving as Bioorthogonal Gating for Melphalan.
Angewandte ChemieCovalent drugs have experienced a revival in recent decades due to their advantageous pharmacodynamic profiles and targeting of "undruggable" proteins. However, balancing selectivity, reactivity, and potency is essential for the safe and effective drugs.
Hanlin Xu +6 more
semanticscholar +1 more source
The Bioorthogonal Isonitrile–Chlorooxime Ligation
Journal of the American Chemical Society, 2019Bioorthogonal reactions are valuable tools for the selective labeling and imaging of natural products and proteins. Here, we present the reaction between isonitriles and chlorooximes as a ligation that proceeds quickly (k ≈ 1 M-1 s-1) and with high chemoselectivity in an aqueous environment.
Rebecca J. B. Schäfer +5 more
openaire +3 more sources
Journal of the American Chemical Society
The advancement of bioorthogonal cleavage platforms has emerged as a critical frontier in chemical biology, offering precise molecular liberation through physiologically compatible activation mechanisms.
Xiao-Wei Xu +9 more
semanticscholar +1 more source
The advancement of bioorthogonal cleavage platforms has emerged as a critical frontier in chemical biology, offering precise molecular liberation through physiologically compatible activation mechanisms.
Xiao-Wei Xu +9 more
semanticscholar +1 more source
Biomaterials
In situ activation of prodrugs or photosensitizers is a promising strategy for specifically killing tumor cells while avoiding toxic side effects. Herein, we originally develop a bioorthogonally activatable prodrug and pro-photosensitizer system to ...
Yu Teng +10 more
semanticscholar +1 more source
In situ activation of prodrugs or photosensitizers is a promising strategy for specifically killing tumor cells while avoiding toxic side effects. Herein, we originally develop a bioorthogonally activatable prodrug and pro-photosensitizer system to ...
Yu Teng +10 more
semanticscholar +1 more source
Angewandte Chemie
Single-atom nanozymes (SAzymes) with atomically dispersed active sites are potential substitutes for natural enzymes. A systematic study of its multiple functions can in-depth understand SAzymes's nature, which remains elusive.
Luyan Wu +7 more
semanticscholar +1 more source
Single-atom nanozymes (SAzymes) with atomically dispersed active sites are potential substitutes for natural enzymes. A systematic study of its multiple functions can in-depth understand SAzymes's nature, which remains elusive.
Luyan Wu +7 more
semanticscholar +1 more source
Bioorthogonal Phosphines: Then and Now
Israel Journal of Chemistry, 2022AbstractBioorthogonal chemistry traces its roots to a seminal report by Saxon and Bertozzi, who described a modified Staudinger reaction between organic azides and triaryl phosphines. This finding not only inspired several biological pursuits, but also launched an entire field of reaction discovery.
Robert S. Dorn, Jennifer A. Prescher
openaire +1 more source
Angewandte Chemie
Fluorogenic bioorthogonal probes are crucial tools in biomedical research, which enables non-invasive wash-free imaging of specific biomolecules in living systems.
Peiling Dai +10 more
semanticscholar +1 more source
Fluorogenic bioorthogonal probes are crucial tools in biomedical research, which enables non-invasive wash-free imaging of specific biomolecules in living systems.
Peiling Dai +10 more
semanticscholar +1 more source
Dual-Locked Enzyme-Activatable Bioorthogonal Fluorescence Turn-On Imaging of Senescent Cancer Cells.
Journal of the American Chemical SocietyBioorthogonal pretargeting optical imaging shows the potential for enhanced diagnosis and prognosis. However, the bioorthogonal handles, known for being "always reactive", may engage in reactions at unintended sites with their counterparts, resulting in ...
Xin-Zhu Wang +5 more
semanticscholar +1 more source