Late-stage systemic immune effectors in Plasmodium berghei ANKA infection: biopterin and oxidative stress [PDF]
Pteridines, 2015 To investigate the involvement of systemic oxidative stress in the pathogenesis of murine cerebral malaria, mice were infected with the Plasmodium berghei (P. berghei) ANKA 6653 strain.
Dogruman-Al Funda +4 more
doaj +2 more sources
Pteridines, 2012 Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response.
Girgin Gözde +5 more
doaj +1 more source
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency [PDF]
, 2015 Tyrosine hydroxylase catalyses the hydroxylation of L-tyrosine to l-DOPA, the rate- limiting step in the synthesis of catecholamines. Mutations in the TH gene encoding tyrosine hydroxylase are associated with the autosomal recessive disorder tyrosine ...
Allegri, Gabriella +17 more
core +3 more sources
Pterin determination in cerebrospinal fluid: state of the art
Pteridines, 2017 The analysis of pterins in the cerebrospinal fluid (CSF) is mandatory for the etiologic diagnosis of inborn errors of dopamine and serotonin metabolism.
Guibal Pierre +3 more
doaj +1 more source
Dopa-responsive dystonia and hyperprolactinaemia : a novel association in two sisters [PDF]
, 2007 Dopa-Responsive Dystonia (DRD) is a rare hereditary condition of childhood-onset dystonia which responds dramatically to treatment with levodopa. It was first described in 1971 as a "hereditary progressive basal ganglia disease with marked diurnal ...
Cachia, Mario J., Galea, Janabel
core
Metabolic Processes Preserved as Biosignatures in Iron-Oxidizing Microorganisms: Implications for Biosignature Detection on Mars [PDF]
Iron-oxidizing bacteria occupy a distinct environmental niche. These chemolithoautotrophic organisms require very little oxygen (when neutrophilic) or outcompete oxygen for access to Fe(II) (when acidophilic).
Emerson, David +3 more
core +1 more source
The role of folate transport in antifolate drug action in Trypanosoma brucei [PDF]
, 2016 The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexate ...
Ali +66 more
core +2 more sources
First Synthesis of a Representative, Natural Pterin Glycoside: 2’-O-(α-D-Glucopyranosyl)biopterin [PDF]
, 2009 Glycosylation of N(2)-(N,N-dimethylaminomethylene)-1’-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl) ethyl]biopterin (14) with the novel donor 4,6-di-O-acetyl-2,3-di-O-(4-methoxybenzyl)-α-D-glucopyranosyl bromide (19) in the presence of silver triflate and ...
Hanaya, Tadashi +2 more
core
Inflammation and oxidative stress caused by nitric oxide synthase uncoupling might lead to left ventricular diastolic and systolic dysfunction in patients with hypertension [PDF]
, 2015 Objective: To investigate the role of oxidative stress, inflammation, hypercoagulability and neuroendocrine activation in the transition of hypertensive heart disease to heart failure with preserved ejection fraction (HFPEF).
Bodó I +14 more
core +2 more sources
Inhibitory Effects of Pteridines on the Cytochrome P-450 Enzyme System
Pteridines, 1997 The effects of 17 different pteridine derivatives on rat liver microsomal cytochrome P-450 catalyzed degradation of aminoantipyrin were studied.
Horejsi Renate +5 more
doaj +1 more source