Results 1 to 10 of about 5,435 (148)

Biopterin in Parkinson's disease. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1987
Tetrahydrobiopterin is an essential co-factor in the natural synthesis of dopamine. Oral tetrahydrobiopterin was given in small doses to four patients with early Parkinson's disease but had no discernible effect.
W. Jacobson, P. O. Behan, A. P. Moore, W. L. F. Armarego   +3 more
openaire   +3 more sources

Synthetic studies on pterin glycosides: the first synthesis of 2′-O-(α-d-glucopyranosyl)biopterin [PDF]

, 2009
L-Rhamnose was led, in a 14-step-sequence, to N2-(N,N-dimethylaminomethylene)-1′-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin (23), an appropriately protected precursor for 2′-O-glycosylation, while 4,6-di-O-acetyl-2,3-di-O-(4-methoxybenzyl)-α-
Cha, Cho, Choi, Coolidge, Crane, Fitzpatrick, Forrest, Gigg, Hanaya, Hanaya, Hanaya, Hanaya, Hanaya, Hanessian, Hatfield, Hiroki Baba, Hiroki Toyota, Hiroshi Yamamoto, Hough, Ibatullin, Ikawa, Kaufman, Kaufman, Kwon, Lee, Lemieux, Lin, Lönn, Marletta, Matsunaga, Ness, Noguchi, Saito, Stewart, Suzuki, Tadashi Hanaya, Taylor, Wolfrom, Wulff, Yin   +39 more
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Peripheral biopterin and neopterin in schizophrenia and depression

Psychiatry Research, 2021
Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin and biopterin may link peripheral immune system activation and central neurotransmitter alterations.
Flurin Cathomas, Anahita Rassi, Stefan Kaiser, Erich Seifritz, Beat Thöny, Federica Klaus, Federica Klaus, Rebecca Schlegel, Karoline Guetter   +8 more
openaire   +4 more sources

An Efficient Synthesis of 2'-O-(β-D-Ribofuranosyl)biopterin [PDF]

, 2008
N(2)-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O (trimethylsilyl)biopterin (4) was prepared from biopterin (1a, 86% overall yield) in 5 steps. Glycosylation of 4 with 1,2,3,5-tetra-O-acetyl-β D-ribofuranose (5a) and its 2,3,5-tri-O-
Fujita, Hiroshi, Hanaya, Tadashi, Pfleiderer, Wolfgang, Soranaka, Kazuyuki, Torigoe, Kiyoshi, Yamamoto, Hiroshi   +5 more
core   +1 more source

Neurological aspects of biopterin metabolism. [PDF]

Archives of Disease in Childhood, 1986
Plasma total biopterin concentration was measured by bioassay in 59 infants with hyperphenylalaninaemia and in 50 children with developmental regression and or movement disorder with normal plasma phenylalanine concentrations. In infants with raised phenylalanine concentrations plasma biopterin concentrations were significantly raised in proportion to ...
R. J. Leeming, Isabel M. Smith, Keith Hyland, N. P. C. Cavanagh   +3 more
openaire   +3 more sources

First Synthesis of Biopterin α-D-Glucoside [PDF]

, 2009
A novel glycosyl donor, 4,6-di-O-acetyl-2,3-di-O-(4-methoxy-benzyl)-α-D-glucopyranosy bromide (15) was efficiently prepared from D-glucose in 8 steps.
Baba, Hiroki, Hanaya, Tadashi, Yamamoto, Hiroshi   +2 more
core   +1 more source

First Synthesis of Asperopterin A, an Isoxanthopterin Glycoside from Aspergillus Oryzae [PDF]

, 2013
The key precursor, N-2-(N,N -dimethylaminomethylene)-6-hydroxymethyl-8-methyl-3-[2-(4-nitrophenyl)ethyl]-7-xanthopterin (16) was efficiently prepared from 2,5-diamino-6-methylamino-3H-pyrimidin-4-one (5) and ethyl 3-(tert-butyldimethylsilyloxy)-2 ...
Hanaya, Tadashi, Yamamoto, Hiroshi
core   +1 more source

Tetrahydro‐6‐biopterin is associated with tetrahydro‐7‐biopterin in primary murine mast cells [PDF]

FEBS Letters, 1992
Murine bone marrow‐derived mast cells proliferate in response to interleukin 3. In addition to 6‐biopterin, 7‐biopterin was identified in these cells by HPLC analysis of iodine oxidized extracts and by alkaline permanganate oxidation to the 6‐ and 7‐carboxylic acids. 7‐Biopterin comprised 31.9 (± 7.7)% of the total biopterin.
Ziegler, I., Hültner, L.
openaire   +4 more sources

New aspects in biopterin biosynthesis in man [PDF]

FEBS Letters, 1981
Tetrahydrobiopterin is synthesized from guanosine triphosphate (GTP)in several enzymatic steps [1,2]. Details of the pathway of the biopterin biosynthesis in mammals are still unresolved [3]. In rat and human brain the rate-limiting enzyme was GTP cyclohydrolase [2], followed by D-erythro-7,8-dihydroneopterin triphosphate synthetase.
Häusermann, Max, Niederwieser, Alois, Curtius, Hans-Christoph, Ghisla, Sandro   +3 more
openaire   +4 more sources

The role of folate transport in antifolate drug action in Trypanosoma brucei [PDF]

, 2016
The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexate ...
Ali, Alsford, Alsford, Alsford, Brun, Burkard, Carver, Chatelain, Checchi, Colasante, Dridi, Dridi, Eadsforth, Ellenberger, Fairlamb, Fairlamb, Fairlamb, Franco, Gangjee, Gangjee, Gazanion, Gibson, Glover, Goldman, Graf, Hertz-Fowler, Hirumi, Jackson, Jamonneau, Jansen, Jones, Klaus, Kündig, Langmead, Li, Massimine, Matovu, Meiser, Mpanya, Odiit, Ong, Ouameur, Panigrahi, Pelphrey, Redmond, Richard, Richard, Robays, Shanks, Sienkiewicz, Sienkiewicz, Simarro, Sirotnak, Sirotnak, Sokolova, Spinks, Synold, Tan, Ubeda, van den Hoff, Vickers, Vincent, Wahlin, Wang, Webber, Widemann, World Health Organization   +66 more
core   +2 more sources