The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study [PDF]
Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
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Allergology International, 2019 Background: Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.
Saki Kasuga +10 more
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A systematic review and meta-analysis of pteridines in mild cognitive impairment and Alzheimer’s disease [PDF]
BMC GeriatricsBackground Alterations in specific pteridine metabolites, particularly neopterin, biopterin, and tetrahydrobiopterin have been reported in mild cognitive impairment, Alzheimer’s disease, and other types of dementia.
Arduino A. Mangoni, Angelo Zinellu
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Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]
PLoS Neglected Tropical DiseasesMammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
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Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome [PDF]
Acute and Critical Care, 2023 Background Coronary atherosclerosis is the leading cause of coronary artery disease. Several investigations have indicated that tear-sensitive plaques contain macrophages and T cells. Neopterin is an essential cellular immune response biomarker. The main
Ibrahim Kember +4 more
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Czech Journal of Animal Science, 2015 The effect of surgical castration with local anesthesia using lidocaine on neopterin, biopterin, and cortisol blood plasma concentrations in piglets was studied.
P. Maršálek +3 more
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Dystonia and Biopterin Deficiency
Pediatric Neurology Briefs, 1988 Five patients with childhood dystonia associated with reduced CSF biopterin, responsive to levodopa, and characterized by diurnal and exertional variation are reported from the Developmental and Metabolic Neurology Branch, National Institute of ...
J Gordon Millichap
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Synthesis of biopterin and related pterin glycosides
IUBMB Life, 2013 AbstractCertain pterins having a hydroxyalkyl side chain at C‐6 have been found as glycosidic forms in certain prokaryotes, such as 2′‐O‐(α‐D‐glucopyranosyl)biopterin from various kinds of cyanobacteria, and limipterin from a green sulfur photosynthetic bacterium.
Tadashi, Hanaya, Hiroshi, Yamamoto
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Tetrahydrobiopterin, responsive, hyperphenylalaninemia without biopterin defiCIency
Pteridines, 2000 Hyperphenylalaninemia (HPA) results from a deficiency of the enzyme phenylalanine hydroxylase (PAH) or of its cofactor, tetrahydrobiopterin (BH4). In 1999, Kure et al reported that some patients with PAH deficiency showed lowering of blood Phe levels after BH4 loading (1). We found several patients with HPA whose serum phenylalanine levels decreased at
Shintaku Haruo +3 more
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Peripheral biopterin and neopterin in schizophrenia and depression.
Psychiatry Research, 2021 Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ).
F. Klaus +7 more
semanticscholar +1 more source