The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study [PDF]
Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
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A Single-Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates. [PDF]
JIMD RepABSTRACT Background Tetrahydrobiopterin (BH4) deficiencies comprise a group of five neurometabolic disorders caused by five genetic defects responsible for BH4 biosynthesis and regeneration. Their global prevalence remains unknown, and variance exists among different countries.
Jarrah O, Nouri M, Al Shamsi A.
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Effects of phototherapy on biopterin, neopterin, tryptophan, and behavioral neuroinflammatory reaction in patients with post-stroke depression. [PDF]
Sci RepThe aim of this study was to investigate the overall effects of phototherapy on biopterin (BH4), neopterin (BH2), tryptophan (Trp), and behavioral neuroinflammatory reaction in patients with post-stroke depression.
Liu L, Wu Z, Lu Y, Lu W, Su G, Zhou Z.
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Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome [PDF]
Acute and Critical Care, 2023 Background Coronary atherosclerosis is the leading cause of coronary artery disease. Several investigations have indicated that tear-sensitive plaques contain macrophages and T cells. Neopterin is an essential cellular immune response biomarker. The main
Ibrahim Kember +4 more
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Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]
PLoS Neglected Tropical DiseasesMammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
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Dystonia and Biopterin Deficiency
Pediatric Neurology Briefs, 1988 Five patients with childhood dystonia associated with reduced CSF biopterin, responsive to levodopa, and characterized by diurnal and exertional variation are reported from the Developmental and Metabolic Neurology Branch, National Institute of ...
J Gordon Millichap
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Biopterin-Responsive Hyperphenylalaninemia
Journal of Nutritional Science and Vitaminology, 1992 Seymour Kaufman
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Czech Journal of Animal Science, 2015 The effect of surgical castration with local anesthesia using lidocaine on neopterin, biopterin, and cortisol blood plasma concentrations in piglets was studied.
P. Maršálek +3 more
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Tetrahydrobiopterin, responsive, hyperphenylalaninemia without biopterin defiCIency
Pteridines, 2000 Hyperphenylalaninemia (HPA) results from a deficiency of the enzyme phenylalanine hydroxylase (PAH) or of its cofactor, tetrahydrobiopterin (BH4). In 1999, Kure et al reported that some patients with PAH deficiency showed lowering of blood Phe levels after BH4 loading (1). We found several patients with HPA whose serum phenylalanine levels decreased at
Shintaku Haruo +3 more
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Attenuation of Biopterin Synthesis Prevents Escherichia coli K1 Invasion of Brain Endothelial Cells and the Development of Meningitis in Newborn Mice [PDF]
Journal of Infectious Diseases, 2012 Muthusamy V. Shanmuganathan +3 more
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