The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study [PDF]
Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
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A Single-Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates. [PDF]
JIMD RepABSTRACT Background Tetrahydrobiopterin (BH4) deficiencies comprise a group of five neurometabolic disorders caused by five genetic defects responsible for BH4 biosynthesis and regeneration. Their global prevalence remains unknown, and variance exists among different countries.
Jarrah O, Nouri M, Al Shamsi A.
europepmc +4 more sources
An Efficient Synthesis of 2'-O-(β-D-Ribofuranosyl)biopterin [PDF]
Pteridines, 2008 N2-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O-(trimethylsilyl)biopterin (4) was prepared from biopterin (1a, 86% overall yield) in 5 steps.
Hanaya Tadashi +5 more
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The High Concentration of Biopterin In Breast Milk and It's Absorption During the Neonatal Period [PDF]
Pteridines, 1995 Breast milk has been found to contain high levels of biopterin compounds, whose physiological roles have attracted attention through newly discovered functions, particularly. as a cofactor for biosynthesis of nitric oxide.
Iizuka Tadashi +7 more
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A systematic review and meta-analysis of pteridines in mild cognitive impairment and Alzheimer’s disease [PDF]
BMC GeriatricsBackground Alterations in specific pteridine metabolites, particularly neopterin, biopterin, and tetrahydrobiopterin have been reported in mild cognitive impairment, Alzheimer’s disease, and other types of dementia.
Arduino A. Mangoni, Angelo Zinellu
doaj +2 more sources
The urinary biopterin in autism spectrum disorder [PDF]
Pteridines, 2021 The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals.
Waligóra Aleksandra +4 more
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Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome [PDF]
Acute and Critical Care, 2023 Background Coronary atherosclerosis is the leading cause of coronary artery disease. Several investigations have indicated that tear-sensitive plaques contain macrophages and T cells. Neopterin is an essential cellular immune response biomarker. The main
Ibrahim Kember +4 more
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Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]
PLoS Neglected Tropical DiseasesMammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
doaj +2 more sources
Enzymatic Synthesis of Four Stereoisomers of 7-0xo-biopterin and Determination of the Absolute Structure of Ichthyopterin [PDF]
Pteridines, 1990 Enzymatic conversion of stereoisomers of biopterin (3a-d) to the 7-oxo-biopterin isomers (4a-d) was performed with a new pterin 7-oxidase extracted from carp skin.
Takikawa Shin Ichiro, Matsuura Sadao
doaj +2 more sources
Serum Biopterin as a Marker of Immune Activation in the Spontaneously Diabetic BB Rat [PDF]
Pteridines, 1998 Tetrahydrobiopterin (BH4), is a pteridine product which is released by rodent macrophages and fibroblasts upon activation by cytokines. It has previously been reported as a potentially useful marker for monitoring immune activation during the prediabetic
Galloway Tamara +4 more
doaj +2 more sources