Journal of Fungi, 2023 Fusarium graminearum is a causal organism of Fusarium head blight in cereals and maize. Although a few secondary metabolites produced by F. graminearum are considered disease virulence factors, many molecular products of biosynthetic gene clusters ...
Carmen Hicks +9 more
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The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]
, 2012 There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Amy J. Gerc +5 more
core +13 more sources
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. [PDF]
PLoS ONE, 2011 Filamentous marine cyanobacteria are extraordinarily rich sources of structurally novel, biomedically relevant natural products. To understand their biosynthetic origins as well as produce increased supplies and analog molecules, access to the clustered ...
Rashel V Grindberg +10 more
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Comparative Genomics and Metabolomics in the Genus
mSystems, 2020 Using automated genome analysis tools, it is often unclear to what degree genetic variability in homologous biosynthetic pathways relates to structural variation.
Daniel Männle +7 more
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Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. [PDF]
PLoS ONE, 2013 BACKGROUND: Heterologous expression of bacterial biosynthetic gene clusters is currently an indispensable tool for characterizing biosynthetic pathways.
David Cole Stevens +5 more
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Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans. [PDF]
PLoS ONE, 2012 Fungal secondary metabolites are a rich source of medically useful compounds due to their pharmaceutical and toxic properties. Sequencing of fungal genomes has revealed numerous secondary metabolite gene clusters, yet products of many of these ...
Kirsi Bromann +5 more
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Valinomycin biosynthetic gene cluster in Streptomyces: conservation, ecology and evolution. [PDF]
PLoS ONE, 2009 Many Streptomyces strains are known to produce valinomycin (VLM) antibiotic and the VLM biosynthetic gene cluster (vlm) has been characterized in two independent isolates.
Andrea M Matter +4 more
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Discovery of Pyranoviolin A and Its Biosynthetic Gene Cluster in Aspergillus violaceofuscus
Frontiers in Microbiology, 2020 A new polyketide-non-ribosomal peptide hybrid molecule, pyranoviolin A (1), was discovered from the genome-sequenced fungus Aspergillus violaceofuscus CBS 115571 and was characterized to be the first pyranonigrin analog harboring the C-3 methoxy group ...
Xingxing Wei +4 more
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Molecular Plant-Microbe Interactions, 2023 Onion center rot is caused by at least four species of genus Pantoea (P. ananatis, P. agglomerans, P. allii, and P. stewartii subsp. indologenes). Critical onion pathogenicity determinants for P.
Mei Zhao +8 more
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Microbial Biotechnology, 2021 Summary Butenyl‐spinosyn, a promising biopesticide produced by Saccharopolyspora pogona, exhibits stronger insecticidal activity and a broader pesticidal spectrum. However, its titre in the wild‐type S.
Jie Rang +14 more
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