Results 41 to 50 of about 379,309 (342)
Butirosin-biosynthetic Gene Cluster from Bacillus circulans.
The Journal of Antibiotics, 2000 Butirosin is an interesting 2-deoxystreptamine (DOS)-containing aminoglycoside antibiotic produced by non-actinomycete Bacilli. Recently we were successful in purification of 2-deoxy-scyllo-inosose synthase from butirosin-producer Bacillus circulans as the key enzyme for the biosynthesis of DOS, in cloning of the responsible gene (btrC), and in its ...
Yasumasa Ota +6 more
openaire +3 more sources
BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs [PDF]
Genome Research, 2019 Predicting biosynthetic gene clusters (BGCs) is critically important for discovery of antibiotics and other natural products. While BGC prediction from complete genomes is a well-studied problem, predicting BGCs in fragmented genomic assemblies remains challenging.
Dmitry Meleshko +6 more
openaire +2 more sources
Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics
Journal of Fungi, 2021 Previously, DNA microarrays analysis showed that, in co-culture with Bacillus subtilis, a biosynthetic gene cluster anchored with a nonribosomal peptides synthetase of Aspergillus niger is downregulated.
Gregory Evdokias +7 more
doaj +1 more source
The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus [PDF]
Microbiology, 2006 The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and sequenced from Streptomyces fungicidicus ATCC 21013. The 84 kb gene cluster contains 25 ORFs and is located within a 116 kb genetic locus that was fully sequenced.
Xihou, Yin, T Mark, Zabriskie
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The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic
PLoS ONE, 2020 The type I polyketide SF2487/A80577 (herein referred to as tetromadurin) is a polyether tetronate ionophore antibiotic produced by the terrestrial Gram-positive bacterium Actinomadura verrucosospora.
Rory F. Little +3 more
doaj +2 more sources
Heterologous ectoine production in Escherichia coli : By-passing the metabolic bottle-neck [PDF]
, 2008 Peer reviewedPublisher ...
Bestaver, Thorsten +2 more
core +2 more sources
Transcriptional regulation of the novobiocin biosynthetic gene cluster [PDF]
Microbiology, 2009 The aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and novG. We investigated the location of transcriptional promoters within this cluster by insertion of transcriptional ...
Dangel, Volker +6 more
openaire +3 more sources
mBio, 2019 Access to whole-genome sequences has exposed the general incidence of the so-called cryptic biosynthetic gene clusters (BGCs), thereby renewing their interest for natural product discovery.
L. Martinet +9 more
semanticscholar +1 more source
Heterologous expression of the diazaquinomycin biosynthetic gene cluster [PDF]
Journal of Industrial Microbiology and Biotechnology, 2019 Abstract Members of the diazaquinomycin class of natural products have shown potent and selective activity against Mycobacterium tuberculosis. However, poor aqueous solubility has prevented extensive studies in animal models thus far. Our long-term goal is to harness knowledge regarding diazaquinomycin biosynthesis towards the generation
Jana, Braesel +2 more
openaire +2 more sources
Microorganisms, 2021 Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal ...
Liliya Horbal +5 more
doaj +1 more source