Results 61 to 70 of about 379,309 (342)

Biosynthetic Gene Cluster of a d‐Tryptophan‐Containing Lasso Peptide, MS‐271

ChemBioChem, 2018
MS‐271, produced by Streptomyces sp. M‐271, is a lasso peptide natural product comprising 21 amino acid residues with a d‐tryptophan at its C terminus. Because lasso peptides are ribosomal peptides, the biosynthesis of MS‐271, especially the mechanism of
Zhi-Mei Feng, Yasushi Ogasawara, S. Nomura, T. Dairi   +3 more
semanticscholar   +1 more source

Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]

, 2019
O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol, Machado, Henrique, Monk, Jonathan M, Palsson, Bernhard O, Seif, Yara   +4 more
core   +2 more sources

Identifying the Biosynthetic Gene Cluster for Triacsins with an N-hydroxytriazene Moiety

bioRxiv, 2018
Triacsins are a family of natural products containing an N-hydroxytriazene moiety not found in any other known secondary metabolites. Though many studies have examined the biological activity of triacsins in lipid metabolism, the biosynthesis of ...
Frederick F. Twigg, W. Cai, Wei Huang, Joyce Liu, Michio Sato, Tynan J. Perez, Jiaxin Geng, Moriel J. Dror, Ismael Montanez, Tate L. Tong, Hyunsu Lee, Wenjun Zhang   +11 more
semanticscholar   +1 more source

Biosynthesis of thiocarboxylic acid-containing natural products. [PDF]

, 2018
Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products ...
Deng, Youchao, Dong, Liao-Bin, Duan, Yanwen, He, Cyndi Qixin, Houk, KN, Huang, Yong, Kang, Dingding, Rudolf, Jeffrey D, Shen, Ben, Wang, Nan   +9 more
core   +1 more source

Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb.

Organic Letters, 2018
Quinolidomicin A1 is the largest macrolide compound from terrestrial sources, consisting of a 60-membered ring, and its biosynthetic gene cluster was revealed to be over 200 kb. The gene cluster for quinolidomicin was cloned and heterologously expressed.
T. Hashimoto, J. Hashimoto, I. Kozone, Keita Amagai, Teppei Kawahara, Shunji Takahashi, H. Ikeda, K. Shin‐ya   +7 more
semanticscholar   +1 more source

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

Identification of Terpene-Related Biosynthetic Gene Clusters in Tobacco through Computational-Based Genomic, Transcriptomic, and Metabolic Analyses

Agronomy, 2023
Terpenes and terpenoids contribute aroma and flavor that influence consumer preferences in selecting plant-based products. Computational identification of biosynthetic gene clusters (BGCs) in plants can pave the way for future biosynthetic genetic ...
Roel C. Rabara, Chengalrayan Kudithipudi, Michael P. Timko   +2 more
doaj   +1 more source

Permanent Draft Genome Sequences of Three Frankia sp. Strains That Are Atypical, Noninfective, Ineffective Isolates [PDF]

, 2017
Here, we present draft genome sequences for three atypical Frankia strains (lineage 4) that were isolated from root nodules but are unable to reinfect actinorhizal plants. The genome sizes of Frankia sp. strains EUN1h, BMG5.36, and NRRL B16386 were 9.91,
Ghodhbane-Gtari, Faten, Gtari, Maher, Gueddou, Abdellatif, Hezbri, Karima, Ktari, Amir, Morris, Krystalynne, Nouioui, Imen, Sen, Arnab, Simpson, Stephen, Swanson, Erik, Thomas, W. Kelley, Tisa, Louis S.   +11 more
core   +2 more sources

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

Nucleic Acids Res., 2022
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and ...
Barbara R. Terlouw, K. Blin, J. Navarro-Muñoz, Nicole E. Avalon, M. Chevrette, Susan Egbert, Sanghoon Lee, David Meijer, Michael J J Recchia, Zachary L. Reitz, Jeffrey A. van Santen, Nelly Sélem-Mojica, T. Tørring, Liana Zaroubi, Mohammad Alanjary, Gajender Aleti, César Aguilar, Suhad A. A. Al-Salihi, Hannah E. Augustijn, J. A. Avelar-Rivas, L. A. Avitia-Dominguez, F. Barona-Gómez, Jordan Bernaldo-Agüero, Vincent A. Bielinski, Friederike Biermann, Thomas J. Booth, Victor J Carrion Bravo, R. Castelo-Branco, F. Chagas, Pablo Cruz-Morales, Chao Du, Katherine R. Duncan, A. Gavriilidou, Damien Gayrard, K. Gutiérrez-García, K. Haslinger, Eric J. N. Helfrich, J. V. D. van der Hooft, A. Jati, Edward Kalkreuter, Nikolaos Kalyvas, K. Kang, S. Kautsar, Wonyong Kim, Aditya M. Kunjapur, Yong-Xin Li, Geng-Min Lin, Catarina Loureiro, Joris J. R. Louwen, Nico L L Louwen, G. Lund, Jonathan Parra, B. Philmus, Bita Pourmohsenin, Lotte J U Pronk, Adriana Rego, D. Rex, S. Robinson, L. R. Rosas-Becerra, E. T. Roxborough, M. Schorn, D. Scobie, K. S. Singh, N. Sokolova, Xiaoyu Tang, Daniel W. Udwary, A. Vigneshwari, Kristiina Vind, Sophie P J M Vromans, Valentin Waschulin, Sam E. Williams, Jaclyn M. Winter, Thomas E. Witte, Huali Xie, Dong Yang, Jingwei Yu, Mitja M. Zdouc, Zheng Zhong, J. Collemare, Roger G. Linington, T. Weber, M. Medema   +81 more
semanticscholar   +1 more source

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes [PDF]

, 2016
We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez
Barona-Gomez, Francisco, Cruz-Morales, Pablo, Feldmann, Jorg, Kopp, Johannes Florian, Martinez-Guerrero, Christian, Mojica, Nelly Selem, Ramos-Aboites, Hilda, Yáñez-Guerra, Luis Alfonso   +7 more
core   +1 more source