Results 11 to 20 of about 173,216 (260)
A biosynthetic pathway for anandamide [PDF]
Proceedings of the National Academy of Sciences, 2006 The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis.
Jie, Liu +10 more
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Unusual free oligosaccharides in human bovine and caprine milk
Scientific Reports, 2022 Free oligosaccharides are abundant macronutrients in milk and involved in prebiotic functions and antiadhesive binding of viruses and pathogenic bacteria to colonocytes.
Wei-Chien Weng +8 more
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Antibiotics ‐ cloning of biosynthetic pathways [PDF]
FEBS Letters, 1990 Biosynthetic pathways leading to antibiotics have often been found to be clustered, and new organizational forms of multifunctional enzymes have been discovered. Such polyenzymes accomplish the synthesis of complex metabolites such as peptides or polyketides by a sequence of enzymatic reactions.
Kleinkauf, Horst, von Döhren, Hans
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Shared PKS Module in Biosynthesis of Synergistic Laxaphycins
Frontiers in Microbiology, 2020 Cyanobacteria produce a wide range of lipopeptides that exhibit potent membrane-disrupting activities. Laxaphycins consist of two families of structurally distinct macrocyclic lipopeptides that act in a synergistic manner to produce antifungal and ...
Lassi Matti Petteri Heinilä +5 more
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Using Gene Expression to Study Specialized Metabolism—A Practical Guide
Frontiers in Plant Science, 2021 Plants produce a vast array of chemical compounds that we use as medicines and flavors, but these compounds’ biosynthetic pathways are still poorly understood.
Riccardo Delli-Ponti +2 more
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Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. [PDF]
PLoS ONE, 2013 BACKGROUND: Heterologous expression of bacterial biosynthetic gene clusters is currently an indispensable tool for characterizing biosynthetic pathways.
David Cole Stevens +5 more
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Targeting the GPI biosynthetic pathway [PDF]
Pathogens and Global Health, 2018 The GPI (Glycosylphosphatidylinositol) biosynthetic pathway is a multistep conserved pathway in eukaryotes that culminates in the generation of GPI glycolipid which in turn anchors many proteins (GPI-APs) to the cell surface. In spite of the overall conservation of the pathway, there still exist subtle differences in the GPI pathway of mammals and ...
Usha, Yadav, Mohd Ashraf, Khan
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Tricin Biosynthesis and Bioengineering
Frontiers in Plant Science, 2021 Tricin (3',5'-dimethoxyflavone) is a specialized metabolite which not only confers stress tolerance and involves in defense responses in plants but also represents a promising nutraceutical.
Pui Ying Lam +6 more
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Synthetic and Systems Biotechnology, 2022 Complex peptide natural products exhibit diverse biological functions and a wide range of physico-chemical properties. As a result, many peptides have entered the clinics for various applications.
Sebastian L. Wenski +2 more
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Spontaneity in the patellamide biosynthetic pathway [PDF]
Organic & Biomolecular Chemistry, 2006 Post-translationally modified ribosomal peptides are unusual natural products and many have potent biological activity. The biosynthetic processes involved in their formation have been delineated for some, but the patellamides represent a unique group of these metabolites with a combination of a macrocycle, small heterocycles and d-stereocentres.
Milne, F. Bruce +4 more
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