Results 11 to 20 of about 2,606 (151)

Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement. [PDF]

Ann Transl Med, 2020
This study aimed to investigate the pathological characteristics of BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) with glomerular involvement in kidney transplant recipients.Forty-four patients with glomerular BKPyV infection were retrospectively included for analysis.
Chen XT, Deng RH, Yang SC, Hou XT, Li J, Chen YY, Yang HF, Wang ZY, Wang CX, Qiu J, Chen LZ, Chen WF, Huang G.   +12 more
europepmc   +4 more sources

Incidence, Risk Factors, and Outcomes of Kidney Transplant Recipients With BK Polyomavirus-Associated Nephropathy. [PDF]

Kidney Int Rep, 2023
BK polyomavirus-associated nephropathy (BKPyVAN) is associated with graft dysfunction and loss; however, knowledge of immunosuppression reduction strategies and long-term graft, and patient outcomes across the disease spectrum is lacking.This cohort study included 14,697 kidney transplant recipients in Australia and New Zealand (2005-2019), followed ...
Gately R, Milanzi E, Lim W, Teixeira-Pinto A, Clayton P, Isbel N, Johnson DW, Hawley C, Campbell S, Wong G.   +9 more
europepmc   +3 more sources

BK Polyomavirus-associated nephropathy - diagnostic and treatment standard. [PDF]

Nephrol Dial Transplant
ABSTRACT BK polyomavirus (BKPyV) is recognized as a significant viral complication of kidney transplantation. Prompt immunosuppression reduction reduces early graft failure rates due to BK polyomavirus-associated nephropathy (BKPyVAN), however, modulation of immunosuppression can lead to acute rejection.
Al-Talib M, Welberry-Smith M, Macdonald A, Griffin S.   +3 more
europepmc   +5 more sources

Levels of donor-derived cell-free DNA and chemokines in BK polyomavirus-associated nephropathy. [PDF]

Clin Transplant, 2022
AbstractBackgroundBK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers reflecting tissue injury (donor‐derived cell‐free DNA [dd‐cfDNA]) or immune activation (C‐X‐C motif chemokine
Mayer KA, Omic H, Weseslindtner L, Doberer K, Reindl-Schwaighofer R, Viard T, Tillgren A, Haindl S, Casas S, Eskandary F, Heinzel A, Kozakowski N, Kikić Ž, Böhmig GA, Eder M.   +14 more
europepmc   +3 more sources

Clinical Relevance of Absolute BK Polyoma Viral Load Kinetics in Patients With Biopsy Proven BK Polyomavirus Associated Nephropathy. [PDF]

Front Med (Lausanne), 2021
Introduction: The absolute BK viral load is an important diagnostic surrogate for BK polyomavirus associated nephropathy (PyVAN) after renal transplant (KTX) and serial assessment of BK viremia is recommended. However, there is no data indicating which particular viral load change, i.e., absolute vs.
Omić H, Kläger JP, Herkner H, Aberle SW, Regele H, Weseslindtner L, Schrag TA, Bond G, Hohenstein K, Watschinger B, Werzowa J, Strassl R, Eder M, Kikić Ž.   +13 more
europepmc   +5 more sources

Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy. [PDF]

J Zhejiang Univ Sci B, 2021
BK polyomavirus-associated nephropathy (BKPyVAN) is a common cause of allograft failure. However, differentiation between BKPyVAN and type I T cell-mediated rejection (TCMR) is challenging when simian virus 40 (SV40) staining is negative, because of the similarities in histopathology. This study investigated whether donor-derived cell-free DNA (ddcfDNA)
Shen J, Guo L, Lei W, Liu S, Yan P, Liu H, Zhou J, Zhou Q, Liu F, Jiang T, Wang H, Wu J, Chen J, Wang R.   +13 more
europepmc   +4 more sources

Cellular immunity in BK polyomavirus associated nephropathy following adult kidney transplantation

Transplantation Reports, 2022
Background: BK polyomavirus (BKPyV) is the most important polyomavirus affecting renal transplant recipients. BKPyV associated nephropathy (BKVAN) is seen in about 5% of renal transplant patients and can lead to graft loss in up to 50% of cases ...
Laila Schneidewind, Uwe Grunwald, Desiree L. Dräger, Thomas Neumann, Jennifer Kranz, Oliver W. Hakenberg   +5 more
doaj   +2 more sources

Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients. [PDF]

Ann Transl Med, 2020
The positive predictive value (PPV) of urinary decoy cells for diagnosing BK polyomavirus associated-nephropathy (BKPyVAN) is low. This study was designed to increase the PPV of urinary decoy cells for diagnosing BKPyVAN in kidney transplant recipients.A total of 105 urine sediment samples from 105 patients with positive BK viruria and decoy cells were
Chen XT, Chen WF, Hou XT, Yang SC, Yang HF, Li J, Deng RH, Huang Y, Nuertai Y, Wang CX, Qiu J, Huang G.   +11 more
europepmc   +4 more sources

2105. Early-onset and Late-onset BK Polyomavirus-associated Nephropathy: A 10-year Retrospective Analysis [PDF]

Open Forum Infect Dis, 2022
Abstract Background Polyomavirus-associated nephropathy (BKVAN) is one of the serious causes of allograft dysfunction and allograft loss in kidney transplant (KT) patients. Most of the patients were diagnosed with BKVAN within the first year after transplantation but some more cases of BKVAN occur ...
Thiandech, Vichitra, Kantachuvesiri, Surasak, Bruminhent, Jackrapong   +2 more
europepmc   +2 more sources

BK Polyomavirus-Associated Nephropathy and Hemorrhagic Cystitis in Transplant Recipients—What We Understand and What Remains Unclear [PDF]

Viruses
The reactivation of BK polyomavirus (BKPyV) during severe immunosuppression plays a crucial role in two significant syndromes observed in transplant recipients: BK polyomavirus-associated nephropathy (BKPyVAN) in kidney transplant patients and BK ...
Tang-Her Jaing, Yi-Lun Wang, Tsung-Yen Chang   +2 more
doaj   +2 more sources