Results 11 to 20 of about 2,195 (192)

Biology of the BKPyV: An Update [PDF]

Viruses, 2017
The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium.
Francois Helle, Etienne Brochot, Lynda Handala, Elodie Martin, Sandrine Castelain, Catherine Francois, Gilles Duverlie   +6 more
doaj   +3 more sources

Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells.

PLoS Pathogens, 2016
Polyomavirus BK (BKPyV) frequently reactivates in immunosuppressed renal transplant recipients (RTRs) and may lead to graft loss due to BKPyV-induced interstitial nephritis (BKVN). Little is known on the differentiation of CD8+ T cells targeting BKPyV in
Michiel C van Aalderen, Ester B M Remmerswaal, Kirstin M Heutinck, Anja Ten Brinke, Mariet C W Feltkamp, Neelke C van der Weerd, Karlijn A M I van der Pant, Frederike J Bemelman, René A W van Lier, Ineke J M Ten Berge   +9 more
doaj   +5 more sources

Simultaneous BK Polyomavirus (BKPyV)-associated nephropathy and hemorrhagic cystitis after living donor kidney transplantation [PDF]

Journal of Clinical Virology, 2016
BK polyomavirus (BKPyV) commonly reactivates after kidney transplantation, and can cause polyomavirus-associated nephropathy (PyVAN), whereas after allogeneic stem cell transplantation the most frequent manifestation of BKPyV is polyomavirus-associated ...
Auvinen, Eeva, Helanterä, Ilkka, Hirsch, Hans H., Lautenschlager, Irmeli, Lempinen , Marko, Mannonen, Laura, Ortiz, Fernanda, Räisänen-Sokolowski, Anne, Wernli, Marion   +8 more
core   +5 more sources

Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Transplantation

Microorganisms
Polyomavirus BK (BKPyV)-associated nephropathy (BKPyV-nephropathy) remains a significant cause of premature kidney allograft failure. In the absence of effective antiviral treatments, current therapeutic approaches rely on immunosuppression (IS ...
Michela Cioni, Stella Muscianisi, Marica De Cicco, Sabrina Basso, Hans H. Hirsch, Iris Fontana, Laura Catenacci, Jessica Bagnarino, Mariangela Siciliano, Oriana Montana Lampo, Gloria Acquafredda, Lou Tina Diana Boti, Jessica Rotella, Eleonora Bozza, Jennifer Zumelli, Kristiana Mebelli, Fausto Baldanti, Massimo Cardillo, Marco Zecca, Arcangelo Nocera, Mario Luppi, Enrico Verrina, Fabrizio Ginevri, Patrizia Comoli   +23 more
doaj   +2 more sources

Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells. [PDF]

PLoS Pathogens, 2023
Most humans have a lifelong imperceptible BK Polyomavirus (BKPyV) infection in epithelial cells lining the reno-urinary tract. In kidney transplant recipients, unrestricted high-level replication of donor-derived BKPyV in the allograft underlies ...
Elias Myrvoll Lorentzen, Stian Henriksen, Christine Hanssen Rinaldo   +2 more
doaj   +3 more sources

Tumor Necrosis Factor-Alpha Inhibits the Replication of Patient-Derived Archetype BK Polyomavirus While Activating Rearranged Strains [PDF]

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
To date, no drugs are approved for BK polyomavirus (BKPyV) reactivation, a major cause of nephropathy after kidney transplantation. Recently, tumor necrosis factor‐α (TNF‐α) blockade has been proposed as a promising therapy, however, the effect of TNF ...
Feld, Pascal, Fliser, Danilo, Gasparoni, Gilles, Gläser, Lars, Janssen, Martin, Kattler-Lackes, Kathrin, Klinz, Jonas, Laue, Michael, Lauterbach, Marcel A., Lauterbach-Rivière, Lise, Lohse, Stefan, Möller, Lars, Rahmann, Sven, Schmit, David, Schüssler, Jessica, Smola, Sigrun, Sternjakob, Anna, Stöckle, Michael, Thuringer, Lucia, Toews, Lina Kathrin, Walter, Jörn   +20 more
core   +2 more sources

Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells. [PDF]

PLoS Pathogens
BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients.
Elias Myrvoll Lorentzen, Stian Henriksen, Christine Hanssen Rinaldo   +2 more
doaj   +3 more sources

Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population [PDF]

Virology Journal, 2017
Background The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively.
Iqra Hussain, Fareeda Tasneem, Muhammed Umer, Ayesha Pervaiz, Muslim Raza, Muhammad Imran Arshad, Naveed Shahzad   +6 more
doaj   +4 more sources

Discriminating between JCPyV and BKPyV in Urinary Virome Data Sets [PDF]

Viruses, 2021
Polyomaviruses are abundant in the human body. The polyomaviruses JC virus (JCPyV) and BK virus (BKPyV) are common viruses in the human urinary tract. Prior studies have estimated that JCPyV infects between 20 and 80% of adults and that BKPyV infects between 65 and 90% of individuals by age 10.
Rita Mormando, Alan J. Wolfe, Catherine Putonti   +2 more
openaire   +4 more sources

HLA-B Leader Dimorphism Predicts BK Polyomavirus Replication After Kidney Transplant. [PDF]

HLA
ABSTRACT BK polyomavirus (BKPyV) and Cytomegalovirus (CMV) often replicate after kidney transplantation, with management limited to reducing immunosuppression and risking rejection. Among genetic factors that may modulate the antiviral response, HLA evolutionary divergence (HED, allowing a greater diversity of antigen presentation) and the HLA‐B leader
Aubry A, Demey B, Helle F, Fourdinier O, Lion J, Desoutter J, Brochot E, Guillaume N.   +7 more
europepmc   +2 more sources