Results 21 to 30 of about 2,195 (192)

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines. [PDF]

Microbiologyopen
In this study, we analyzed the BK polyomavirus (BKPyV) genome derived from three rodent cell lines established from BKPyV induced tumors. BKPyV derived one cell line had a large deletion. The noncoding control region (NCCR) of BKPyV derived from these cell lines had the same structure as viruses induced tumors.
Shioda S, Kasai F, Ozawa M, Ohtani A, Iemura M, Watanabe K, Kohara A.   +6 more
europepmc   +2 more sources

1189. Correlation of BK polyomavirus (BKPyV)-specific Immunity and BKPyV Viruria within 6 months after Kidney Transplantation: A Prospective Cohort Study [PDF]

Open Forum Infectious Diseases, 2020
Abstract Background Since viral-specific immunity has been shown to be correlated with viral containment in solid organ transplant recipients, we investigated an association of BK polyomavirus (BKPyV)-specific immunity and BKPyV viruria in kidney transplant (KT) recipients.
Siripoon, Tanaya, Kantachuvesiri, Surasak, Apiwattanakul, Nopporn, Bruminhent, Jackrapong   +3 more
openaire   +1 more source

Rejection after BKPyV DNAemia-Are We Treating Too Cautiously? [PDF]

Transpl Int
Moest WT, de Vries APJ, van Rijn AL, van der Helm D, Kers J, Feltkamp MCW, Rotmans JI.   +6 more
europepmc   +2 more sources

Genotypes and Variants of BKPyV in Organ Donors after Brain Death

International Journal of Molecular Sciences, 2022
Kidney transplantation from a donor with latent BKPyV might be the cause of serious complications, such as BK virus-associated nephropathy. The aim of the study was to determine the prevalence of BKPyV infection in donors after brain death (DBDs), to analyse the molecular variation of BKPyV and to compare clinical and inflammation parameters of DBDs ...
Jacek Furmaga, Marek Kowalczyk, Olga Furmaga-Rokou, Christos A. Rokos, Tomasz Zapolski, Leszek Krakowski, Andrzej Jakubczak, Sławomir Rudzki   +7 more
openaire   +3 more sources

Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability

Virology Journal, 2023
Background Human polyomavirus BK (BKPyV) causes associated nephropathy and contributes to urinary tract cancer development in renal transplant recipients. Large tumor antigen (LT) is an early protein essential in the polyomavirus life cycle.
Yueh-Han Hsu, Chun-Nun Chao, Hsin-Yi Huang, Pei-Wen Zhao, Pang-Hung Hsu, Cheng-Huang Shen, San-Yuan Chen, Chiung-Yao Fang   +7 more
doaj   +1 more source

First-In-Human, Randomized, Placebo-Controlled, SAD and MAD Trial to Evaluate Safety, Tolerability, and PK/PD Modeling of Potravitug in Healthy Adults. [PDF]

Clin Transl Sci
ABSTRACT BK polyomavirus (BKPyV) affects 10%–30% of kidney‐transplant recipients receiving immunosuppressive therapy, potentially leading to nephropathy, graft dysfunction, graft loss, and increased mortality. Despite the medical need, no targeted therapies exist.
May M, Bialek-Waldmann JK, Wright A, Gruver S, Grant J, Eicher B, Seidenberg J, Parzmair GP, Beck J.   +8 more
europepmc   +2 more sources

Fatal BK polyomavirus-associated pneumonia: report of two cases with literature review

BMC Infectious Diseases, 2023
Background In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe ...
Yuchen Wang, Yiling Fang, Ziyan Yan, Renfei Xia, Wenli Zeng, Wenfeng Deng, Jian Xu, Xiaoqin Feng, Jie Peng, Yun Miao   +9 more
doaj   +1 more source

Intracellular Low Iron Exerts Anti-BK Polyomavirus Effect by Inhibiting the Protein Synthesis of Exogenous Genes

Microbiology Spectrum, 2021
BK polyomavirus (BKPyV) is a small double-stranded DNA virus and ubiquitous human pathogen that particularly affects immunocompromised individuals. Antiviral therapy for BKPyV is urgently needed.
Jiajia Sun, Yejing Shi, Huichun Shi, Yumin Hou, Chunlan Hu, Yigang Zeng, Guoyi Wu, Tongyu Zhu   +7 more
doaj   +1 more source

Mother-to-child transmission of oncogenic polyomaviruses BKPyV, JCPyV and SV40

Journal of Infection, 2020
Polyomavirus (PyV) infections have been associated with different diseases. BK (BKPyV), JC (JCPyV) and simian virus 40 (SV40) are the three main PyVs whose primary infection occurs early in life. Their vertical transmission was investigated in this study.PyV sequences were analyzed by the digital droplet PCR in blood, serum, placenta, amniotic fluid ...
Elisa Mazzoni, Elena Pellegrinelli, Chiara Mazziotta, Carmen Lanzillotti, John Charles Rotondo, Ilaria Bononi, Maria Rosa Iaquinta, Marco Manfrini, Fortunato Vesce, Mauro Tognon, Fernanda Martini   +10 more
openaire   +2 more sources

Viral infections in prostate carcinomas in Chilean patients [PDF]

, 2015
© 2015 Rodríguez et al.Background: A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined.
A Bellizzi, A Pal, A Zambrano, Aldo Gaggero, AM Roda Husman de, AR Patel, B Akgül, C Moyret-Lalle, CK Choo, D Das, Diego Carrillo, DR Lowy, E Shtivelman, Francisco Aguayo, G Russo, GJ Leiros, H Feng, H zur Hausen, Hector Rodríguez, Iván Gallegos, J Cuzick, J Ferlay, J Hrbacek, Jorge Castillo, Jorge Levican, JS Rhim, Juan P. Muñoz, K Reiss, KF Harris, M Schmitt, M Schmitt, M Tognon, Massimo Tommasino, ML Martinez-Fierro, Mónica L. Acevedo, N Albinana-Gimenez, N Babel, N Peña, N Shahzad, NJ Whitaker, Omar Espinoza-Navarro, Oscar León, P Randhawa, R Tachezy, S Bofill-Mas, S Delbue, SK Lau, T Bethge, T Gheit, T Gheit, T Iwasaka, Tarik Gheit, V Balis, WA Knowles, WG Nelson, Y Lin   +55 more
core   +3 more sources