Results 91 to 100 of about 15,201 (184)

Multiscale screening and identifying specific targets for artesunate in suppressing bladder cancer

Frontiers in Pharmacology
BackgroundBladder cancer (BLCA) is a highly aggressive urinary malignancy with high mortality in advanced stages, posing a significant health risk. Artesunate (ART), a derivative of artemisinin, has been demonstrated with potent anti-tumor activity in ...
Yi Yuan, Guangdi Chu, Qingyue Ma, Zhijuan Liang, Ye Liang, Haitao Niu, Haitao Niu   +6 more
doaj   +1 more source

Ferroptosis-related lncRNA AL136084.3 is associated with NUPR1 in bladder cancer

Discover Oncology
Background LncRNAs are critical regulators of bladder cancer (BLCA), and ferroptosis is a newly discovered cell death responsible for mediating apoptosis and tumorigenesis.
Jing Zhou, Li Zhang, Hao Wu, Sheng-Lin Gao, Xiao-Ping Chen, Li-Feng Zhang, Cui-Ping Zhao, Bing-Bing Wei, Yu Bai   +8 more
doaj   +1 more source

Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics analysis

Frontiers in Immunology
BackgroundBladder cancer (BLCA) continues to be a significant cause of cancer mortality in the urinary tract, with therapeutic resistance representing a major barrier to improving patient outcomes.
Zhaokai Zhou, Yajun Chen, Zhan Wang, Shuai Yang, Zhengrui Li, Run Shi, Ruizhi Wang, Kui Liu, Xiaojuan Tang, Qi Li, Ran Xu   +10 more
doaj   +1 more source

BLCA-RegMap portal: a co-regulatory influence network view of bladder cancer heterogeneity

, 2022
Introduction: Bladder cancer studies performed in a variety of laboratories and by anumber of large-scale projects have given an unparalleled amount of information on tumors and in vitro models. Consolidating these data into an easily accessible and comprehensive system-level format is crucial to accelerate systems oncology model development.Methods ...
Pawlak, Geoffrey, Puig, Julia, Dispot, Aurélien, Dhifli, Wajdi, Elati, Mohamed   +4 more
openaire   +1 more source

TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis

Cell Death Discovery
Bladder cancer (BLCA) is a prevalent malignancy characterized by high recurrence and metastasis rates. Emerging evidence suggests that the NRF2-GPX4 axis is closely associated with ferroptosis. The transcriptional coactivator with PDZ-binding motif (TAZ)
Zhen Song, Shikai Gui, Xuepeng Rao, Gan Zhang, Yu Cheng, Tao Zeng   +5 more
doaj   +1 more source

SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer

Cell & Bioscience
Background Aberrant interplay between epigenetic reprogramming and metabolic rewiring events contributes to bladder cancer progression and metastasis.
Xiaojing Wang, Peipei Zhang, Jiaqi Yan, Jingyi Huang, Yan Shen, Hongchao He, Hongjing Dou   +6 more
doaj   +1 more source

Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway

International Journal of Biological Sciences
Ubiquitination, a prevalent and highly dynamic reversible post-translational modification, is tightly regulated by the deubiquitinating enzymes (DUBs) superfamily. Among them, OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 1 (OTUB1) stands out as a critical member of the OTU deubiquitinating family, playing a pivotal role as a tumor regulator
Liao, Yihao, Liang, Jiaming, Wang, Youzhi, Li, An, Liu, Wenbo, Zhong, Boqiang, Wang, Keke, Zhou, Diansheng, Guo, Tao, Guo, Jianing, Yu, Xi, Jiang, Ning   +11 more
openaire   +2 more sources

The Fishermen’s Village: A Case Study of a Bagong Lipunan Improvement of Sites and Services Project in Bago Aplaya, Talomo, Davao City [PDF]

This article is a product of a nine-month training and application program implemented by the micro component of the Economic and Social Impact Analysis/Women in Development (ESIA/WID) and the Food Systems Program of the East-West Center Resource Systems
Conti, Filomena A.
core   +2 more sources

A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer

Frontiers in Oncology
PurposeBladder cancer (BLCA) is one of the most common urogenital malignancies in the world. The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA.
Yiqiang Da, Zirong Lu, Zirong Lu, Zijian Zhu, Hongrui Tai, Yuan Liu, Yichao Zhu, Yichao Zhu   +7 more
doaj   +1 more source

Predicting drug response of tumors from integrated genomic profiles by deep neural networks

, 2018
The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response.
Chen, Hung-I Harry, Chen, Yidong, Chiu, Yu-Chiao, Gorthi, Aparna, Huang, Yufei, Wang, Li-Ju, Zhang, Songyao, Zhang, Tinghe   +7 more
core   +1 more source