Results 101 to 110 of about 15,495 (203)

Chromosome 1 Open Reading Frame 35 Drives Colorectal Cancer Progression by Enhancing Tumor‐Intrinsic Proliferation and CD8+ T Cell Suppression

MedComm, Volume 7, Issue 4, April 2026.
This study identifies C1orf35 as a key driver of colorectal cancer progression through a dual mechanism. It promotes tumor‐intrinsic cell proliferation and migration via the c‐Myc/PYCR2 axis, and suppresses anti‐tumor immunity by impairing CD8+ T‐cell immune surveillance, nominating it as a novel therapeutic target in colorectal cancer.
Shaosen Zhang, Changjiang Yang, Xunye Xu, Lan Lan, Ziyi He, Jiaoting Chen, Caihong Wang   +6 more
wiley   +1 more source

A metabolic reprogramming-related gene signature correlates with prognosis and proliferation of BLCA

Discover Oncology
Bladder cancer (BLCA) is one of the most frequent urothelium carcinoma, but with poor prognosis due to lack of reliable predictive biomarkers. Metabolic reprogramming involving in various nutrients, and is reported to be closely associated with malignant progression in BLCA.
Yaoxin Wu, Yi Luo, Tinghao Li
openaire   +3 more sources

KRAB Zinc‐Finger Protein ZNF205 Promotes Hepatocellular Carcinoma via p53 Pathway Repression

Cancer Science, Volume 117, Issue 4, Page 1057-1071, April 2026.
ZNF205 functions as a critical oncogenic regulator in hepatocellular carcinoma (HCC), where it interacts with p53 and functionally suppresses its transcriptional activity by competitively inhibiting p53 binding to target gene promoters. This p53 inactivation mechanism critically contributes to tumor progression in HCC. ABSTRACT The tumor suppressor p53
Xiaofen Huang, Yingchuan Yang, Yuan Ma, Wei Hao, Jingzhuo Jin, Yue Ding, Yiming Zhang, Xiuyuan Zhang, Xinli Li, Qin Song, Jiaqi Liu, Bingxin Liu, Yuanjun Zhai, Chunling Zhao, Jin Wu, Chunyan Tian   +15 more
wiley   +1 more source

Mitochondrial DNA copy number variation across human cancers. [PDF]

, 2016
Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number variation across 22 tumor types profiled by The Cancer Genome Atlas project.
Al-Ahmadie, Hikmat A, Hakimi, A Ari, Lee, William, Miller, Martin L, Reznik, Ed, Riaz, Nadeem, Sander, Chris, Sarungbam, Judy, Seshan, Venkatraman E, Tickoo, Satish K, Şenbabaoğlu, Yasin   +10 more
core   +1 more source

Risk Assessment and Management of Brucella canis Introduction via Commercial Dog Imports Into France

Risk Analysis, Volume 46, Issue 4, April 2026.
ABSTRACT Canine brucellosis, caused by Brucella canis, is a likely underdiagnosed zoonotic disease that leads to reproductive failure in dogs and economic losses for kennels. Since 2020, cases in mainland France have been on the rise, with most attributed to the importation of dogs from Eastern Europe. However, the risk of introducing B.
Patrick Mvumbi, Gina Zanella, Guillaume Crozet   +2 more
wiley   +1 more source

Solving problems of clustering and classification of cancer diseases based on DNA methylation data [PDF]

, 2016
The article deals with the problem of diagnosis of oncological diseases based on the analysis of DNA methylation data using algorithms of cluster analysis and supervised learning.
Druzhkov, PN, Ivanchenko, MV, Krylov, IB, Meyerov, IB, Polovinkin, AN, Zaikin, AA, Zolotykh, NY   +6 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, Volume 20, Issue 3, Page 779-803, March 2026.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT

Advanced Science
Bladder cancer (BLCA) is a prevalent cancer with high case‐fatality rates and a substantial economic burden worldwide. Understanding its molecular underpinnings to guide clinical management is crucial. Ferroptosis, a recently described non‐apoptotic form
Jianmin Liu, Yongwen Luo, Siming Chen, Gang Wang, Wan Jin, Wenyu Jiang, Mingxing Li, Yejinpeng Wang, Jingtian Yu, Houyi Wei, Renjie Zhang, Fenfang Zhou, Lingao Ju, Yi Zhang, Yu Xiao, Kaiyu Qian, Xinghuan Wang   +16 more
doaj   +1 more source

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. [PDF]

, 2017
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types.
Balanis, Nikolas G, Beck, Lillie, Braas, Daniel, Cass, Ashley, Chan, Shawna, Christofk, Heather R, Delgado, Adrian, Friedman, Michael, Go, James, Graeber, Thomas G, Graham, Nicholas A, Hurtz, Christian, Larson, Steven M, Lomova, Anastasia, Mellinghoff, Ingo K, Minasyan, Aspram, Multani, Asha S, Müschen, Markus, Ng, Carina, Palaskas, Nicolaos, Port, Elisa, Qiao, Rong, Schultz, Nikolaus, Ten Hoeve, Johanna, Wu, Hong, Zhao, Sophie   +25 more
core   +3 more sources

Characterization of Immune Infiltrating Cells in Bladder Urothelial Carcinoma and Its Clinical Significance

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Immune cells have been linked to the initiation and progression of tumors, and their presence is often used to predict disease prognosis. However, when it comes to bladder urothelial carcinoma (BLCA), there has not been a comprehensive investigation into the function and prognostic value of different immune cell types.
Xin Yan, Xiaoyu Tang, Linfa Guo, Ziqi He, Shaoxi Liu, Shaojie Wu, Zhilong Li, Tong‐Zu Liu, Hang Zheng, Weibing Zhang, Sheng Li   +10 more
wiley   +1 more source