Comprehensive analysis of normal adjacent to tumor transcriptomes. [PDF]
Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies. However, little is known about the transcriptomic profile of NAT, how it is influenced by the tumor, and how the profile compares with non-tumor ...
Aran, Dvir +8 more
core +3 more sources
Pan-cancer classifications of tumor histological images using deep learning [PDF]
Histopathological images are essential for the diagnosis of cancer type and selection of optimal treatment. However, the current clinical process of manual inspection of images is time consuming and prone to intra- and inter-observer variability. Here we
Caruana, Dennis +8 more
core +1 more source
The role of the BLCA-4 nuclear matrix protein in bladder cancer
Bladder cancer (BC) affects usually older people. According to information provided by the National Cancer Registry in 2012. BC was the 4th, in terms of illness, cancer in men and 11th in women. Early diagnosis of bladder cancer is important because detected later has worse prognosis.Diagnosis of bladder cancer is not simple and it is still very ...
Beata, Szymańska, Anna, Długosz
openaire +2 more sources
Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA) [PDF]
Abstract Background As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs). Methods LASSO Cox regression model was used to establish ...
Rui Cao +4 more
openaire +3 more sources
CDCOCA: A statistical method to define complexity dependence of co-occuring chromosomal aberrations [PDF]
Background Copy number alterations (CNA) play a key role in cancer development and progression. Since more than one CNA can be detected in most tumors, frequently co-occurring genetic CNA may point to cooperating cancer related genes.
Baudis, Michael +3 more
core +1 more source
BackgroundAnoikis disrupts the normal apoptotic process in cells, leading to abnormal proliferation and migration, thereby promoting tumor formation and development.
Yusong Zhou +5 more
doaj +1 more source
Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification [PDF]
Motivation: Prediction of phenotypes from high-dimensional data is a crucial task in precision biology and medicine. Many technologies employ genomic biomarkers to characterize phenotypes.
Acunzo, Mario +5 more
core +3 more sources
Apoptosis has been discovered as a mechanism of cell death. The purpose of this study is to identify the diagnostic signature factors related to bladder cancer (BLCA) through apoptosis related genes (ARGs).
Liquan Zhou +5 more
doaj +1 more source
New Cross-Talk Layer between Ultraconserved Non-Coding RNAs, MicroRNAs and Polycomb Protein YY1 in Bladder Cancer [PDF]
MicroRNAs (miRNAs) are highly conserved elements in mammals, and exert key regulatory functions. Growing evidence shows that miRNAs can interact with another class of non-coding RNAs, so-called transcribed ultraconserved regions (T-UCRs), which take part
Castaldo, Luigi +10 more
core +2 more sources
What killed Frame Lake? A precautionary tale for urban planners [PDF]
Frame Lake, located within the city of Yellowknife, Northwest Territories, Canada, has been identified as requiring significant remediation due to its steadily declining water quality and inability to support fish by the 1970s.
Cott, Peter A. +7 more
core +2 more sources

