Results 1 to 10 of about 736,545 (236)
Cold Spring Harbor Perspectives in Biology, 2015 Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood-brain barrier, which allow these vessels to tightly regulate the movement of ions, molecules, and cells between the blood and the
Richard, Daneman, Alexandre, Prat
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The blood–brain barrier: Structure, regulation and drug delivery
Signal Transduction and Targeted Therapy, 2023 Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu +5 more
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Blood—Brain Barrier Genomics [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2001 The blood–brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate ...
J Y, Li, R J, Boado, W M, Pardridge
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A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Fluids and Barriers of the CNS, 2020 The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function.
Hossam Kadry, Behnam Noorani, L. Cucullo
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Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.
Stroke, 2022 Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central nervous system. Structurally comprising the BBB, brain endothelial cells interact with pericytes, astrocytes, neurons, microglia, and perivascular macrophages ...
E. Candelario-Jalil +2 more
semanticscholar +1 more source
Blood-Brain Barrier Genomics [PDF]
Stroke, 2007 Blood-brain barrier (BBB) genomics begins with the isolation of capillaries from fresh animal or human brain and is followed on the same day with the purification of capillary-derived RNA. The identification of microvascular-enriched genes from a whole brain gene microarray is unlikely because the brain capillary endothelial volume is <0.1% of total
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The blood-brain barrier in aging and neurodegeneration
Molecular Psychiatry, 2022 The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma.
Emily G. Knox +4 more
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Blood-Brain Barrier: From Physiology to Disease and Back.
Physiological Reviews, 2019 The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly ...
Melanie D. Sweeney +4 more
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The blood–brain barrier in systemic infection and inflammation
Cellular & Molecular Immunology, 2021 The vascular blood–brain barrier is a highly regulated interface between the blood and brain. Its primary function is to protect central neurons while signaling the presence of systemic inflammation and infection to the brain to enable a protective ...
Ian Galea
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2021 Neuroinflammation is involved in the onset or progression of various neurodegenerative diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage-associated molecular patterns) and/or exogenous pathogens.
F. Takata +3 more
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