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Structure and function of the blood–brain barrier
Neurobiology of Disease, 2010 Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood–brain barrier (BBB), blood–CSF barrier and the arachnoid barrier.
N. Joan Abbott +4 more
doaj +2 more sources
Tumour necrosis factor-α mediates blood—brain barrier damage in HIV-1 infection of the central nervous system [PDF]
Mediators of Inflammation, 1992 The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood–brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour ...
Ciardi, M. +6 more
core +4 more sources
Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27
Biology, 2023 Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses.
Camille Menaceur +4 more
doaj +1 more source
Cells, 2023 Within the neurovascular unit, brain pericytes (BPs) are of major importance for the induction and maintenance of the properties of the blood-brain barrier (BBB) carried by the brain microvessel endothelial cells (ECs).
Camille Menaceur +9 more
doaj +1 more source
The blood–brain barrier: Structure, regulation and drug delivery
Signal Transduction and Targeted Therapy, 2023 Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu +5 more
semanticscholar +1 more source
Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE
Journal of Neuroinflammation, 2021 Background Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular ...
Dylan Krajewski +4 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term.
Rodrigo Azevedo Loiola +14 more
doaj +1 more source
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
Physiological Reports, 2021 Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming socioeconomic impact.
Vardan T. Karamyan
doaj +1 more source
The blood-brain barrier in aging and neurodegeneration
Molecular Psychiatry, 2022 The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma.
Emily G. Knox +4 more
semanticscholar +1 more source