Results 21 to 30 of about 700,468 (343)

Structure and function of the blood–brain barrier

Neurobiology of Disease, 2010
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood–brain barrier (BBB), blood–CSF barrier and the arachnoid barrier.
N. Joan Abbott, Adjanie A.K. Patabendige, Diana E.M. Dolman, Siti R. Yusof, David J. Begley   +4 more
doaj   +1 more source

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Frontiers in Cell and Developmental Biology, 2023
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu, Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Lu Chen, Wanlin Ye, Wanlin Ye, Yi Kang, Yi Kang, Guo Chen, Guo Chen, Tao Zhu, Tao Zhu   +13 more
doaj   +1 more source

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S., Jayasekera, S., Khan, Naveed Ahmed, Kim, K.S., Sissons, J., Stins, M.   +5 more
core   +3 more sources

Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier [PDF]

, 2015
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and ...
Asgari, Nasrin, Berg, Carsten Tue, Khorooshi, Reza, Mørch, Marlene Thorsen, Owens, Trevor   +4 more
core   +2 more sources

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source

The restorative role of annexin A1 at the blood–brain barrier [PDF]

, 2016
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the
A Aggarwal, A Algotsson, A Armulik, A Cignarella, A Kosicka, A Mahringer, A Moheet, A Montagne, A Parimisetty, A Razmara, A Rosell, A Varatharaj, AB Mitchell, ACC Fonseca da, AJ Farrall, AJ Kiliaan, AK Deo, AK Harris, AM Stranahan, AMS Hartz, AMS Hartz, AP Viggars, AR Nelson, B Engelhardt, B Engelhardt, B Harten van, B Obermeier, B Shao, B Stieger, B-O Nilsson, BJ Andreone, BL Hart, BO Popescu, BT Hawkins, BV Zlokovic, BW Chow, BW McColl, C Derada Troletti, C Joseph, C Knott, C Moran, C Wang, CA Raji, CE Tagoe, CH Hillman, CJ Ek, CN Hall, CV Carman, CW D’Acunto, D Virgintino, D Virgintino, DA Eberhard, DR Thal, DW Kim, DY Yoo, E Brailoiu, E Cristante, E Duinkerken Van, E Maggioli, E Pietronigro, E Solito, E Zenaro, F Boraldi, F Bruschi, F Shimizu, FN Doubal, FNE Gavins, FR Walter, G Cheng, G Cirino, G Fredman, G Han, G Leoni, GG Ortiz, GJ Zoppo del, GL Bowman, H Kang, H Kim, H Qosa, H Sun, H Wang, HJ Haar van de, HK Smith, HS Kang, IA Simpson, J Deng, J Guo, J Satoh, J Tu, J-H Liu, JA Shin, JA Shin, JD Sengillo, JH Heo, JI Alvarez, JM Wardlaw, JS Saczynski, K Monastyrskaya, KM Thrailkill, L Bloemendaal van, L Nathan, L Parente, L Raz, L Sanchez-Covarrubias, L Zhou, L-C Chen, LA Profenno, LB Buckman, LD Ghitescu, M Asgari, M Brkic, M Burek, M Burek, M Elahy, M Fuente de la, M Hellström, M Perretti, M Perretti, M Schwaninger, MA Lopez-Ramirez, MA Lopez-Ramirez, MS Thomsen, N Gorlé, N Muradashvili, N Pannacciulli, N Sumi, NJ Abbott, NJ Abbott, NJ Abbott, NR Saunders, NT Pietrani, P Hu, PJ Magistretti, Q-H Liu, R Deane, R Hallmann, R Sankowski, RC Janzer, RD Bell, RF Haseloff, RH McCusker, RO Roberts, RT Kovacic, S Bena, S Burgmans, S Liebner, S Maysami, S McArthur, S Nadkarni, S Nourshargh, S Ouyang, S Probst-Cousin, S Rius-Pérez, S Suzuki, S Taheri, S Tietz, S Wang, SA Vital, SE Headland, SE Kanoski, SE Moss, SN Cooray, T Nishioku, TL Davidson, TO Price, TS Salameh, WS Hoogenboom, Y Luo, Y Yao, Y-F Tu, YH Jing, YH Lee, Z Tucsek, ZZ Luo   +173 more
core   +4 more sources

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V

Molecules, 2015
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch, Jorick Vanbeselaere, Clément P. Delannoy, Aurore Drolez, Caroline Mysiorek, Yann Guérardel, Philippe Delannoy, Sylvain Julien   +7 more
doaj   +1 more source

Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent [PDF]

, 2009
Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a ‘species barrier’ on interspecies experiments.
Card, Cotran, Detwiler, Foster, Foster, Fraser, Goldmann, González, González, Hamir, Hamir, Hamir, Houston, Houston, Houston, Hunter, Jeffrey, McLennan, Nakaoke, Outram, Weller, Zakharov   +21 more
core   +1 more source