Results 21 to 30 of about 963,269 (378)

The blood-brain barrier in aging and neurodegeneration

Molecular Psychiatry, 2022
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma.
Emily G. Knox, M. R. Aburto, G. Clarke, J. Cryan, C. O’Driscoll   +4 more
semanticscholar   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Fluids and Barriers of the CNS, 2019
Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang, Joel S. Pachter   +5 more
doaj   +1 more source

Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]

, 2017
Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E., Brailoiu, Eugen, Brailoiu, G. Cristina, Shipsky, Megan M., Yan, Guang   +4 more
core   +2 more sources

The blood–brain barrier in systemic infection and inflammation

Cellular & Molecular Immunology, 2021
The vascular blood–brain barrier is a highly regulated interface between the blood and brain. Its primary function is to protect central neurons while signaling the presence of systemic inflammation and infection to the brain to enable a protective ...
I. Galea
semanticscholar   +1 more source

Translocating the blood-brain barrier using electrostatics [PDF]

, 2012
Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the ...
Castanho, Miguel A. R. B., Domingues, Marco M., Freire, João M., Ribeiro, Marta M. B., Santos, Nuno C.   +4 more
core   +2 more sources

Blood-Brain Barrier: From Physiology to Disease and Back.

Physiological Reviews, 2019
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly ...
Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, B. Zlokovic   +4 more
semanticscholar   +1 more source

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Nature, 2020
Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized1–6. Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical ...
Axel Montagne, D. Nation, A. Sagare, G. Barisano, Melanie D. Sweeney, A. Chakhoyan, M. Pachicano, Elizabeth Joe, Amy R. Nelson, Lina M. D’Orazio, David P. Buennagel, M. Harrington, T. Benzinger, A. Fagan, J. Ringman, L. Schneider, J. Morris, E. Reiman, R. Caselli, H. Chui, J. Tcw, Yining Chen, J. Pa, P. Conti, Meng Law, A. Toga, B. Zlokovic   +26 more
semanticscholar   +1 more source

Aquaporin and Blood Brain Barrier [PDF]

Current Neuropharmacology, 2010
Large water fluxes continuously take place between the different compartments of the brain as well as between the brain parenchyma and the blood or cerebrospinal fluid.Disturbances in this well-regulated water homeostasis may have deleterious effects on brain function and may be fatal in cases where water accumulates in the brain following pathologies ...
Francesca, Bonomini, Bonomini, Francesca, Rita, Rezzani   +2 more
openaire   +4 more sources

Extracellular vesicles through the blood–brain barrier: a review

Fluids and Barriers of the CNS, 2022
Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain ...
H. Ramos-Zaldívar, Iva Polakovičová, E. Salas-Huenuleo, A. Corvalán, M. Kogan, Claudia P. Yefi, M. Andía   +6 more
semanticscholar   +1 more source