Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.
Stroke, 2022 Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central nervous system. Structurally comprising the BBB, brain endothelial cells interact with pericytes, astrocytes, neurons, microglia, and perivascular macrophages ...
E. Candelario-Jalil +2 more
semanticscholar +1 more source
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Fluids and Barriers of the CNS, 2020 The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function.
Hossam Kadry, Behnam Noorani, L. Cucullo
semanticscholar +1 more source
Measuring the arrival time of an electron wave packet using a dynamical potential barrier [PDF]
Phys. Rev. B 108, 195309 (2023), 2023 A time-dependent potential barrier has been used to probe the arrival-time distribution of the wave packet of a hot electron by raising the barrier to block the packet upon arrival of the packet at the barrier. To see whether the barrier precisely detects the distribution, it is necessary to study an error caused by a finite rising speed of the barrier.
arxiv +1 more source
Blood brain barrier opening is not just blood-brain barrier opening. [PDF]
J Transl MedSharma D, Czarnota GJ.
europepmc +2 more sources
Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
Fluids and Barriers of the CNS, 2019 Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge +5 more
doaj +1 more source
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
Nature, 2020 Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized1–6. Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical ...
Axel Montagne +26 more
semanticscholar +1 more source
The blood–brain barrier in systemic infection and inflammation
Cellular & Molecular Immunology, 2021 The vascular blood–brain barrier is a highly regulated interface between the blood and brain. Its primary function is to protect central neurons while signaling the presence of systemic inflammation and infection to the brain to enable a protective ...
I. Galea
semanticscholar +1 more source
Blood-Brain Barrier: From Physiology to Disease and Back.
Physiological Reviews, 2019 The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly ...
Melanie D. Sweeney +4 more
semanticscholar +1 more source
Extracellular vesicles through the blood–brain barrier: a review
Fluids and Barriers of the CNS, 2022 Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional manner between the bloodstream and brain ...
H. Ramos-Zaldívar +6 more
semanticscholar +1 more source
Research progress on perioperative blood-brain barrier damage and its potential mechanism
Frontiers in Cell and Developmental Biology, 2023 The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu +13 more
doaj +1 more source