Results 31 to 40 of about 963,269 (378)

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Frontiers in Cell and Developmental Biology, 2023
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu, Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Lu Chen, Wanlin Ye, Wanlin Ye, Yi Kang, Yi Kang, Guo Chen, Guo Chen, Tao Zhu, Tao Zhu   +13 more
doaj   +1 more source

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

Advancement of science, 2021
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs as their delivery efficacy to the brain is severely hampered by the presence of the blood–brain barrier (BBB).
Weisen Zhang, A. Mehta, Ziqiu Tong, L. Esser, N. Voelcker   +4 more
semanticscholar   +1 more source

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source

A fruitful fly forward : the role of the fly in drug discovery for neurodegeneration [PDF]

, 2014
AD, Alzheimer’s disease; APP, amyloid precursor protein; BBB, blood brain barrier; GFP, green fluorescent protein; HTS, high-throughput screening; HD, Huntington’s disease; LB, Lewy bodies; PD, Parkinson’s disease; PolyQ, Polyglutamine; RNAi, RNA ...
Briffa, Michelle, Cauchi, Ruben J., Vassallo, Neville   +2 more
core   +1 more source

Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease

Brain : a journal of neurology, 2022
Alzheimer’s disease is a neurodegenerative disorder that causes age-dependent neurological and cognitive declines. The treatments for Alzheimer’s disease pose a significant challenge, because the mechanisms of disease are not being fully understood ...
Qi Wang, Xiaomin Huang, Yixun Su, Guowei Yin, Shouyu Wang, Bin Yu, Hui Li, Junhua Qi, Hui Chen, Wen Zeng, Kai Zhang, A. Verkhratsky, Jianqin Niu, Chenju Yi   +13 more
semanticscholar   +1 more source

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Journal of Neuroinflammation, 2023
Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML).
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt   +8 more
doaj   +1 more source

Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier [PDF]

, 2015
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and ...
Asgari, Nasrin, Berg, Carsten Tue, Khorooshi, Reza, Mørch, Marlene Thorsen, Owens, Trevor   +4 more
core   +1 more source

Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent [PDF]

, 2009
Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a ‘species barrier’ on interspecies experiments.
Card, Cotran, Detwiler, Foster, Foster, Fraser, Goldmann, González, González, Hamir, Hamir, Hamir, Houston, Houston, Houston, Hunter, Jeffrey, McLennan, Nakaoke, Outram, Weller, Zakharov   +21 more
core   +1 more source

The restorative role of annexin A1 at the blood–brain barrier [PDF]

, 2016
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the
A Aggarwal, A Algotsson, A Armulik, A Cignarella, A Kosicka, A Mahringer, A Moheet, A Montagne, A Parimisetty, A Razmara, A Rosell, A Varatharaj, AB Mitchell, ACC Fonseca da, AJ Farrall, AJ Kiliaan, AK Deo, AK Harris, AM Stranahan, AMS Hartz, AMS Hartz, AP Viggars, AR Nelson, B Engelhardt, B Engelhardt, B Harten van, B Obermeier, B Shao, B Stieger, B-O Nilsson, BJ Andreone, BL Hart, BO Popescu, BT Hawkins, BV Zlokovic, BW Chow, BW McColl, C Derada Troletti, C Joseph, C Knott, C Moran, C Wang, CA Raji, CE Tagoe, CH Hillman, CJ Ek, CN Hall, CV Carman, CW D’Acunto, D Virgintino, D Virgintino, DA Eberhard, DR Thal, DW Kim, DY Yoo, E Brailoiu, E Cristante, E Duinkerken Van, E Maggioli, E Pietronigro, E Solito, E Zenaro, F Boraldi, F Bruschi, F Shimizu, FN Doubal, FNE Gavins, FR Walter, G Cheng, G Cirino, G Fredman, G Han, G Leoni, GG Ortiz, GJ Zoppo del, GL Bowman, H Kang, H Kim, H Qosa, H Sun, H Wang, HJ Haar van de, HK Smith, HS Kang, IA Simpson, J Deng, J Guo, J Satoh, J Tu, J-H Liu, JA Shin, JA Shin, JD Sengillo, JH Heo, JI Alvarez, JM Wardlaw, JS Saczynski, K Monastyrskaya, KM Thrailkill, L Bloemendaal van, L Nathan, L Parente, L Raz, L Sanchez-Covarrubias, L Zhou, L-C Chen, LA Profenno, LB Buckman, LD Ghitescu, M Asgari, M Brkic, M Burek, M Burek, M Elahy, M Fuente de la, M Hellström, M Perretti, M Perretti, M Schwaninger, MA Lopez-Ramirez, MA Lopez-Ramirez, MS Thomsen, N Gorlé, N Muradashvili, N Pannacciulli, N Sumi, NJ Abbott, NJ Abbott, NJ Abbott, NR Saunders, NT Pietrani, P Hu, PJ Magistretti, Q-H Liu, R Deane, R Hallmann, R Sankowski, RC Janzer, RD Bell, RF Haseloff, RH McCusker, RO Roberts, RT Kovacic, S Bena, S Burgmans, S Liebner, S Maysami, S McArthur, S Nadkarni, S Nourshargh, S Ouyang, S Probst-Cousin, S Rius-Pérez, S Suzuki, S Taheri, S Tietz, S Wang, SA Vital, SE Headland, SE Kanoski, SE Moss, SN Cooray, T Nishioku, TL Davidson, TO Price, TS Salameh, WS Hoogenboom, Y Luo, Y Yao, Y-F Tu, YH Jing, YH Lee, Z Tucsek, ZZ Luo   +173 more
core   +4 more sources