Results 41 to 50 of about 957,746 (360)

Real-time monitoring of human blood-brain barrier disruption [PDF]

, 2017
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma.
Alahuhta, Seppo, Isokangas, Matti, Keinanen, Tuija, Kiviniemi, Vesa, Korhonen, Vesa, Kortelainen, Jukka, Kuittinen, Outi, Myllyla, Teemu, Nikkinen, Juha, Rytky, Seppo, Siniluoto, Topi, Sonkajarvi, Eila, Tervonen, Osmo, Tuovinen, Timo, Turpeenniemi-Hujanen, Taina, Voipio, Juha   +15 more
core   +2 more sources

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nature Network Boston, 2018
Vascular contributions to cognitive impairment are increasingly recognized1–5 as shown by neuropathological6,7, neuroimaging4,8–11, and cerebrospinal fluid biomarker4,12 studies.
D. Nation, Melanie D. Sweeney, Axel Montagne, A. Sagare, Lina M. D’Orazio, M. Pachicano, F. Sepehrband, Amy R. Nelson, David P. Buennagel, M. Harrington, T. Benzinger, A. Fagan, J. Ringman, L. Schneider, J. Morris, H. Chui, Meng Law, A. Toga, B. Zlokovic   +18 more
semanticscholar   +1 more source

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

Advancement of science, 2021
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs as their delivery efficacy to the brain is severely hampered by the presence of the blood–brain barrier (BBB).
Weisen Zhang, A. Mehta, Ziqiu Tong, L. Esser, N. Voelcker   +4 more
semanticscholar   +1 more source

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]

, 2016
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk, Cheng W., Helga E. Vries, Heusschen R., Ignacio Andres Romero, Miguel Alejandro Lopez‐Ramirez, Waig S.   +6 more
core   +3 more sources

Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment [PDF]

, 2023
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions.
Ahmed, Zubair, Backes, Walter H., Blankesteijn, W. Matthijs, Caiment, Florian, Foulquier, Sébastien, Fulton, Daniel, Jansen, Jacobus F. A., Leenders, Peter, Majcher, Daria, Manukjan, Narek, Smeets, Hubert J., Staals, Julie, Suidgeest, Ernst, van der Weerd, Louise, van Herwijnen, Marcel, van Oostenbrugge, Robert J., Vanmierlo, Tim   +16 more
core   +2 more sources

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source

Resonant spin transport through a superconducting double barrier structure [PDF]

Europhys. Lett. 88, 57003 (2009), 2009
We study resonant transport through a superconducting double barrier structure. At each barrier, due to the proximity effect, an incident electron can either reflect as an electron or a hole (Andreev reflection). Similarly, transport across the barrier can occur via direct tunneling as electrons as well as via the crossed Andreev channel, where a hole ...
arxiv   +1 more source

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V

Molecules, 2015
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch, Jorick Vanbeselaere, Clément P. Delannoy, Aurore Drolez, Caroline Mysiorek, Yann Guérardel, Philippe Delannoy, Sylvain Julien   +7 more
doaj   +1 more source

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Journal of Neuroinflammation, 2023
Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML).
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt   +8 more
doaj   +1 more source

Systematic study of fusion barriers with energy dependent barrier radius [PDF]

arXiv, 2023
Considering energy dependence of the barrier radius in heavy-ion fusion reactions, a modified Siwek-Wilczy\'{n}ski (MSW) fusion cross section formula is proposed. With the MSW formula, the fusion barrier parameters for 367 reaction systems are systematically extracted, based on 443 datasets of measured cross sections. We find that the fusion excitation
arxiv