Results 51 to 60 of about 963,269 (378)

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S., Jayasekera, S., Khan, Naveed Ahmed, Kim, K.S., Sissons, J., Stins, M.   +5 more
core   +3 more sources

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

Nature Communications, 2019
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this process remains unclear.
Koichiro Haruwaka, Ako Ikegami, Y. Tachibana, N. Ohno, H. Konishi, Akari Hashimoto, Mami Matsumoto, D. Kato, Riho Ono, H. Kiyama, A. Moorhouse, J. Nabekura, H. Wake   +12 more
semanticscholar   +1 more source

Interactions of SARS-CoV-2 with the Blood–Brain Barrier

International Journal of Molecular Sciences, 2021
Emerging data indicate that neurological complications occur as a consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
M. Erickson, E. Rhea, Rachel C Knopp, W. Banks   +3 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

International Journal of Molecular Sciences, 2020
Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about passage. Here, we used multiple-time regression analysis to examine the ability of 10 exosome populations derived from mouse, human, cancerous, and non-cancerous ...
W. Banks, Priyanka Sharma, K. Bullock, Hansen M Kim, N. Ludwig, T. Whiteside   +5 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

N-alkylamides : from plant to brain [PDF]

, 2014
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart, Joshi, Tanmayee, Taevernier, Lien, Tatke, Pratima, Verbeke, Frederick, Veryser, Lieselotte, Wynendaele, Evelien   +6 more
core  

The pivotal role of astrocytes in an in vitro stroke model of the blood-brain barrier [PDF]

, 2014
Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could
Anne eMahringer, Carola eFörster, Christoph eRiethmüller, Fabian eGaiser, Jonas eFranz, Winfried eNeuhaus, Winfried eNeuhaus   +6 more
core   +2 more sources

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

Nature Neuroscience, 2020
It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein.
E. Rhea, A. Logsdon, Hansen M. Kim, Lindsey M. Williams, M. Reed, Kristen K. Baumann, Sarah Holden, J. Raber, W. Banks, M. Erickson   +9 more
semanticscholar   +1 more source

Blood-Brain Barrier Overview: Structural and Functional Correlation

Journal of Neural Transplantation and Plasticity, 2021
The blood-brain barrier (BBB) is a semipermeable and extremely selective system in the central nervous system of most vertebrates, that separates blood from the brain's extracellular fluid.
Abeer Alahmari
semanticscholar   +1 more source