Cannabinoids, Blood–Brain Barrier, and Brain Disposition
Pharmaceutics, 2020 Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai +6 more
doaj +1 more source
Reaction rates and the noisy saddle-node bifurcation: Renormalization group for barrier crossing [PDF]
Phys. Rev. Research 3, 013156 (2021), 2019 Barrier crossing calculations in chemical reaction-rate theory typically assume that the barrier is large compared to the temperature. When the barrier vanishes, however, there is a qualitative change in behavior. Instead of crossing a barrier, particles slide down a sloping potential.
arxiv +1 more source
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
Nature Neuroscience, 2020 It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein.
E. Rhea +9 more
semanticscholar +1 more source
Right Treatment Wrong Time: Immunotherapy Administration Post-Radiotherapy Decreases Tumor Burden in a Preclinical Model of Brain Metastasis [PDF]
, 2023 This dissertation (a) provided an in-depth literature review of methods to modulate the blood-brain and blood-tumor barriers to increase drug delivery and efficacy in brain metastases, (b) evaluated the effects of whole-brain radiation therapy on the ...
Blethen, Kathryn Elizabeth
core +1 more source
International Journal of Molecular Sciences, 2020 Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about passage. Here, we used multiple-time regression analysis to examine the ability of 10 exosome populations derived from mouse, human, cancerous, and non-cancerous ...
W. Banks +5 more
semanticscholar +1 more source
Interactions of SARS-CoV-2 with the Blood–Brain Barrier
International Journal of Molecular Sciences, 2021 Emerging data indicate that neurological complications occur as a consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
M. Erickson +3 more
semanticscholar +1 more source
The blood–brain barrier in health and disease: Important unanswered questions
Journal of Experimental Medicine, 2020 The blood vessels of the central nervous system tightly control the movement of ions, molecules, and cells between the blood and tissue. This “blood–brain barrier” is vital for neural homeostasis and protection. This review discusses current knowledge of
C. Profaci +3 more
semanticscholar +1 more source
Blood–Brain Barrier in Brain Tumors: Biology and Clinical Relevance
International Journal of Molecular Sciences, 2021 The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier (BTB), limits the penetration of antineoplastic drugs into the brain, resulting in poor response to treatments.
F. Mo +3 more
semanticscholar +1 more source
Breaking the fortress: a mechanistic review of meningitis-causing bacteria breaching tactics in blood brain barrier. [PDF]
Cell Commun SignalThe blood-brain barrier is a physiological protective barrier around blood vessels in the brain. It prevents most bacteria and harmful substances from entering the brain through the blood.
Quan Y +6 more
europepmc +2 more sources
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source