Relationship between the Increased Haemostatic Properties of Blood Platelets and Oxidative Stress Level in Multiple Sclerosis Patients with the Secondary Progressive Stage [PDF]
Oxidative Medicine and Cellular Longevity, 2015 Multiple sclerosis (MS) is the autoimmune disease of the central nervous system with complex pathogenesis, different clinical courses and recurrent neurological relapses and/or progression. Despite various scientific papers that focused on early stage of
Bijak, Michal +5 more
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Blood Platelets as an Important but Underrated Circulating Source of TGFβ. [PDF]
Int J Mol Sci, 2021 When treating diseases related primarily to tissue remodeling and fibrosis, it is desirable to regulate TGFβ concentration and modulate its biological effects. The highest cellular concentrations of TGFβ are found in platelets, with about 40% of all TGFβ
Karolczak K, Watala C.
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Folia Histochemica et Cytobiologica, 2011 Ulcerative colitis (colitis ulcerosa) is a non-specific inflammatory bowel disease of unknown etiology. Thesymptoms which are observed in the course of ulcerative colitis are: an increase in the number of leukocytes andblood platelets, an increase in the
Beata Polińska +2 more
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Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis. [PDF]
Cells, 2019 The available data, including experimental studies, clearly indicate an excessive intravascular activation of circulating platelets in multiple sclerosis (MS) and their hyper-responsiveness to a variety of physiological activators. Platelet activation is
Saluk-Bijak J, Dziedzic A, Bijak M.
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Obstructive Sleep Apnea: From Intermittent Hypoxia to Cardiovascular Complications via Blood Platelets. [PDF]
Front Neurol, 2018 Obstructive sleep apnea is a chronic condition characterized by recurrent episodes of apneas or hypopneas during sleep leading to intermittent hypoxemia and arousals.
Gabryelska A +3 more
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Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Blood, 2020 Thrombospondin-1 (TSP-1) is released by platelets upon activation and can promote platelet activation, but its role in haemostasis in vivo is unclear.
A. Aburima +7 more
semanticscholar +1 more source
Effects of the interactions between platelets with other cells in tumor growth and progression
Frontiers in Immunology, 2023 It has been confirmed that platelets play a key role in tumorigenesis. Tumor-activated platelets can recruit blood cells and immune cells to migrate, establish an inflammatory tumor microenvironment at the sites of primary and metastatic tumors.
Yaxin Li +5 more
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Flavonolignans inhibit the arachidonic acid pathway in blood platelets. [PDF]
BMC Complement Altern Med, 2017 Bijak M, Saluk-Bijak J.
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Frontiers in Cell and Developmental Biology, 2021 Although platelets and the coagulation factors are components of the blood system, they become part of and contribute to the tumor microenvironment (TME) not only within a solid tumor mass, but also within a hematogenous micrometastasis on its way ...
Wolfgang M. J. Obermann +2 more
doaj +1 more source
Presence and activity of Fibrinogen like protein 2 in platelets.
PLoS ONE, 2023 BackgroundFibrinogen-like protein 2 (FGL2) is a serine protease capable of converting prothrombin into thrombin (i.e., prothrombinase-like activity) while bypassing the classic coagulation cascade.
Izhack Cherny +5 more
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