Results 1 to 10 of about 52,292 (275)

High glucose promotes the progression of colorectal cancer by activating the BMP4 signaling and inhibited by glucagon-like peptide-1 receptor agonist

BMC Cancer, 2023
Background The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respectively.
Bingwei Ma, Xingchun Wang, Hui Ren, Yingying Li, Haijiao Zhang, Muqing Yang, Jiyu Li   +6 more
doaj   +2 more sources

The role of BMP4 in adipose-derived stem cell differentiation: A minireview

Frontiers in Cell and Developmental Biology, 2022
Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines responsible for stem cells’ commitment to differentiation, proliferation, and maturation.
Abdul Malik Setiawan, Abdul Malik Setiawan, Taty Anna Kamarudin, Norzana Abd Ghafar   +3 more
doaj   +2 more sources

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH

Nature Metabolism, 2022
The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed liver biopsies and extensive characterization of 58 individuals with or ...
Xiangyu Li, Tamar Tchkonia, James L Kirkland   +2 more
exaly   +2 more sources

BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells

Cancer & Metabolism, 2023
Background Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest ability to promote glycogenesis among the 14 BMPs in hepatocytes and augmented hepatocellular carcinoma
Jiamin Zhong, Luyao Tian, Yannian Gou, Piao Zhao, Xiangyu Dong, Meichun Guo, Guozhi Zhao, Aohua Li, Ailing Hao, Tong-Chuan He, Jiaming Fan   +10 more
doaj   +2 more sources

Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma [PDF]

Frontiers in Molecular Biosciences
Bone Morphogenetic Protein 4 (BMP4) plays a critical role in development, but its function in pancreatic adenocarcinoma (PAAD) is not well understood.
Ao Wang, Xinglong Shen, Shan Lu, Chao Bi, Yang Cao, Yunfeng Liu, Meng Li, Yun Zhao, Huaizhang Jin, Xiaopeng Shen, Wei Dai, Yang Lei   +11 more
doaj   +2 more sources

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent [PDF]

Stem Cells, 2020
Induced pluripotent stem cell (iPSC)‐derived retinal organoids provide a platform to study human retinogenesis, disease modeling, and compound screening.
Armstrong, Lyle, Carter, Madeleine, Chichagova, Valeria, Georgiou, Maria, Ghareeb, Ali, Hilgen, Gerrit, Lako, Majlinda, Sernagor, Evelyne   +7 more
core   +3 more sources

Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4 [PDF]

International Journal of Nanomedicine, 2013
Yasuyuki Shiozaki,1,2 Takashi Kitajima,4 Tetsuro Mazaki,1,2 Aki Yoshida,1 Masato Tanaka,1 Akihiro Umezawa,5 Mariko Nakamura,6 Yasuhiro Yoshida,3 Yoshihiro Ito,4 Toshifumi Ozaki,1 Akihiro Matsukawa2 1Department of Orthopedic Surgery, Okayama University ...
Shiozaki Y, Kitajima T, Mazaki T, Yoshida A, Tanaka M, Umezawa A, Nakamura M, Yoshida Y, Ito Y, Ozaki T, Matsukawa A   +10 more
doaj   +2 more sources

BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionPeriodontal ligament stem cells (PDLSCs) represent a promising therapeutic cell source for regenerating periodontal tissues impaired by disease.
Yihong Li, Yihong Li, Qinghuang Tang, Liwen Li, Chensheng Lin, Minhui Guo, Yanding Zhang, Fuhua Yan, Minkui Lin, Minkui Lin   +9 more
doaj   +2 more sources

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

Cells, 2020
The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system.
Marianna Szemes, Zsombor Melegh, Jacob Bellamy, Alexander Greenhough, Madhu Kollareddy, Daniel Catchpoole, Karim Malik   +6 more
doaj   +2 more sources

BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease

Cell Death Discovery, 2021
Alzheimer’s disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins.
Xiaoqing Zhang, Juan Li, Li Ma, Hui Xu, Yun Cao, Wei Liang, Jia Ma, Z. Peter Wang, Yuyun Li   +8 more
doaj   +2 more sources