Results 101 to 110 of about 46,344 (243)

Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas. [PDF]

PLoS ONE, 2011
Type-2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion. Bone morphogenetic protein 4 (Bmp4)-Bmp receptor 1A signaling in β cells has recently been reported to be required for insulin ...
Mayu Yasunaga, Nao Oumi, Mitsuhiko Osaki, Yasuhiro Kazuki, Tomoko Nakanishi, Mitsuo Oshimura, Kenzo Sato   +6 more
doaj   +1 more source

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

MicroRNA-378 promotes myogenic differentiation by targeting BMP4

Molecular Medicine Reports, 2016
MicroRNA-378 (miRNA-378) has been reported to have a crucial role in skeletal muscle differentiation; however, the underlying mechanisms have largely remained to be elucidated. The present study employed high‑throughput RNA sequencing to investigate the transcriptome following transfection of miRNA‑378 mimics or control RNAs into C2C12 myoblast cells ...
Huiming, Ju, Yuefei, Yang, Anzhi, Sheng, Yuyu, Qi   +3 more
openaire   +3 more sources

Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

eLife, 2020
During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N -glycanase 1 (NGLY1) is proposed to remove N -glycans from misfolded N -glycoproteins after their retrotranslocation from the ER
Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad   +13 more
openaire   +4 more sources

WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4 [PDF]

Proceedings of the National Academy of Sciences, 2013
Inability to recruit new adipose cells following weight gain leads to inappropriate enlargement of existing cells (hypertrophic obesity) associated with inflammation and a dysfunctional adipose tissue. We found increased expression of WNT1 inducible signaling pathway protein 2 (WISP2) and other markers of WNT activation in human abdominal s.c.
Ann, Hammarstedt, Shahram, Hedjazifar, Lachmi, Jenndahl, Silvia, Gogg, John, Grünberg, Birgit, Gustafson, Eva, Klimcakova, Vladimir, Stich, Dominique, Langin, Markku, Laakso, Ulf, Smith   +10 more
openaire   +2 more sources

Early stages of tooth development in the harbor porpoise Phocoena phocoena

The Anatomical Record, EarlyView.
Abstract Here we describe the stages of tooth development in toothed whales on the basis of the harbor porpoise (Phocoena phocoena). The aim of the study was to find out whether these stages are identical to those of other mammals analyzed so far although toothed whales are homodont and monophyodont.
Lasse M. Mathes, Lennart Müller‐Thomsen, Stefan Huggenberger   +2 more
wiley   +1 more source

Synapse Elimination Triggered by BMP4 Exocytosis and Presynaptic BMP Receptor Activation

Cell Reports, 2018
In vitro screening of signaling molecules involved in neural circuit formation has identified a large number of synaptogenic proteins. However, factors that drive synapse elimination remain elusive. Here, we report that bone morphogenetic protein 4 (BMP4)
Takahito Higashi, Shinji Tanaka, Tadatsune Iida, Shigeo Okabe   +3 more
doaj   +1 more source

Linezolid‐mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition

Arthritis &Rheumatology, EarlyView.
Objective Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Because mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H. W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]

, 2012
Peer reviewedPublisher ...
A Kubo, AK Teo, C. H.-H. Cho, D Zhang, E Kroon, E Wandzioch, F. M. Docherty, H Li, H. M. Docherty, IG Brons, J Ameri, J Cai, J Jonsson, JA Thomson, JF Habener, JK Mfopou, JM Wells, JR Spence, K Takahashi, K. Docherty, KA D’Amour, KA Harrison, KS Zaret, L Vallier, L Vallier, L. Vallier, M Inamura, M Polak, M. Joåo Lima, M. W. B. Trotter, MC Nostro, MF Offield, N. R.-F. Hannan, OG Kelly, R Bort, R Maehr, RI Sherwood, S Brown, ST Rashid, T Touboul, V Ramos-Mejia, W Jiang, Y Kunisada   +42 more
core   +2 more sources