Experimental and Molecular Medicine, 2020 Accumulating evidence suggests that glioma stem cells (GSCs), which are rare cells characterized by pluripotency and self-renewal ability, are responsible for glioblastoma (GBM) propagation, recurrence and resistance to therapies.
Bartłomiej Gielniewski +2 more
exaly +2 more sources
Frontiers in Cellular NeuroscienceBone morphogenetic protein-4 (BMP4) is involved in regulation of neural stem cells (NSCs) proliferation, differentiation, migration and survival. It was previously thought that the treatment of NSCs with BMP4 alone induces astrocytes, whereas the ...
Sutong Xu +12 more
doaj +3 more sources
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation
eLife, 2020 During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported that
A. Galeone +13 more
semanticscholar +5 more sources
Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice [PDF]
eLifeBone morphogenetic protein4 (BMP4) plays numerous roles during embryogenesis and can signal either alone as a homodimer, or together with BMP7 as a more active heterodimer.
Hyung-Seok Kim +6 more
doaj +2 more sources
Epigenetic risk stratification in juvenile myelomonocytic leukemia by targeted methylation analysis of the BMP4 locus [PDF]
Clinical EpigeneticsJuvenile myelomonocytic leukemia (JMML) is a rare pediatric myelodysplastic/myeloproliferative neoplasm characterized by distinct epigenetic signatures that facilitate molecular classification. This study aimed to evaluate the diagnostic utility of locus-
Foued Ghanjati +24 more
doaj +2 more sources
Differentiation of human endometrial stem cells encapsulated in alginate hydrogel into oocyte-like cells [PDF]
BioImpacts, 2023 Introduction: Human endometrial mesenchymal stem cells (hEnMSCs) are a rich source of mesenchymal stem cells (MSCs) with multi-lineage differentiation potential, making them an intriguing tool in regenerative medicine, particularly for the treatment of ...
Diba Ghasemi +10 more
doaj +1 more source
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration
Science Immunology, 2018 Tobias Wertheimer +2 more
exaly +2 more sources
Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]
Organoid, 2023 Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim +3 more
doaj +1 more source
Expression of BMP-4 in dentigerous cyst and ameloblastoma: Is it a differentiation measure?
European Oral Research, 2022 Purpose: This study aimed to determine the expression of Bone Morphogenic Protein-4 (BMP 4) in dentigerous cyst (DC), unicystic-ameloblastoma (UA), and Multicystic-ameloblastoma (MA), and assess whether this marker can be a differentiation measure ...
Soudabeh Sargolzaei +2 more
doaj +1 more source
Regenerative Biomaterials, 2023 Scar-free wound healing is a challenging process due to the excessive deposition of extracellular matrix and collagen. To overcome this issue, hydrogels with superior biochemical and mechanical properties have been used in combination with medicinal ...
L. Chang +9 more
semanticscholar +1 more source