Results 11 to 20 of about 46,344 (243)

Characteristics of quiescent adult neural stem cells induced by the bFGF/BMP4 combination or BMP4 alone in vitro

Frontiers in Cellular Neuroscience
Bone morphogenetic protein-4 (BMP4) is involved in regulation of neural stem cells (NSCs) proliferation, differentiation, migration and survival. It was previously thought that the treatment of NSCs with BMP4 alone induces astrocytes, whereas the ...
Sutong Xu, Xi Zhang, Zhuoqun Li, Chenming Liu, Qiulu Liu, Huazhen Chai, Hongkai Yao, Yuping Luo, Yuping Luo, Siguang Li, Siguang Li, Chun Li, Chun Li   +12 more
doaj   +3 more sources

BMP4 aggravates mitochondrial dysfunction of HRMECs

Heliyon, 2023
Mitochondria are important places for the oxidative phosphorylation of glucose and the maintenance of cell oxidation and antioxidant stability. However, mitochondrial dysfunction causes cell dysfunction. Meanwhile, retinal vascular endothelial cell dysfunction may cause vascular inflammation, hemorrhage, angiogenesis, and other manifestations.
Yong Wang, Hui Li, Jingjing Cao, Aihua Liu, Zhenyu Kou, Weiting An, Jingli Liang, Xiaomin Zhang, Xiaorong Li, Lijie Dong   +9 more
openaire   +3 more sources

BMP4 Activation and Secretion Are Negatively Regulated by an Intracellular Gremlin-BMP4 Interaction [PDF]

Journal of Biological Chemistry, 2006
Bone morphogenetic protein 4 (BMP4) is a potent growth factor that is involved in many important biological processes. Regulation of the level of secreted mature BMP4 determines the biological effects of BMP4 on cells in the local microenvironment. Previous studies suggested that Gremlin, a member of DAN family proteins, antagonizes BMP4 activity by ...
Sun, Jianping, Zhuang, Feng Feng, Mullersman, Jerald E., Chen, Hui, Robertson, Elizabeth J., Warburton, David, Liu, Yi Hsin, Shi, Wei   +7 more
openaire   +3 more sources

Cardiac Differentiation of Adipose Tissue-Derived Stem Cells Is Driven by BMP4 and bFGF but Counteracted by 5-Azacytidine and Valproic Acid

Cell Journal, 2020
Objective: Bone morphogenetic protein 4 (BMP4) and basic fibroblast growth factor (bFGF) play important roles in embryonic heart development.
Sanaz Hasani, Arash Javeri, Asadollah Asadi, Masoumeh Fakhr Taha   +3 more
doaj   +1 more source

Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

Cell Death Discovery, 2022
Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Xingchun Wang, Bingwei Ma, Xin Wen, Hui You, Chunjun Sheng, Le Bu, Shen Qu   +6 more
doaj   +1 more source

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

Cells, 2020
The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system.
Marianna Szemes, Zsombor Melegh, Jacob Bellamy, Alexander Greenhough, Madhu Kollareddy, Daniel Catchpoole, Karim Malik   +6 more
doaj   +1 more source

BMP4 (bone morphogenetic protein 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on BMP4 (bone morphogenetic protein 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Thériault, BL, Nachtigal, MW
openaire   +2 more sources

BMP4, a new prognostic factor for glioma [PDF]

World Journal of Surgical Oncology, 2013
The expression status of bone morphogenetic protein 4 (BMP4) in gliomas is still unclear by now. We try to investigate the relationship between BMP4 expression and the biological behavior of gliomas in order to lay a foundation for the management of these tumors.A total of 630 patients with glioma were enrolled in the study from January 2002 to January
Wu, Qiang, Yao, Jiarui
openaire   +2 more sources

Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]

, 2020
Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony, Horii, Mariko, Parast, Mana M, Touma, Ojeni   +3 more
core   +1 more source

High glucose promotes the progression of colorectal cancer by activating the BMP4 signaling and inhibited by glucagon-like peptide-1 receptor agonist

BMC Cancer, 2023
Background The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respectively.
Bingwei Ma, Xingchun Wang, Hui Ren, Yingying Li, Haijiao Zhang, Muqing Yang, Jiyu Li   +6 more
doaj   +1 more source