Results 21 to 30 of about 52,292 (275)
BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage
Development, 2023 Cardiac lineage specification in the mouse is controlled by TGFβ and WNT signaling. From fly to fish, BMP has been identified as an indispensable heart inducer. A detailed analysis of the role of Bmp4 and its effectors Smad1/5, however, was still missing.
Pavel Tsaytler +8 more
semanticscholar +1 more source
Effects of Treatment with Bone Morphogenetic Protein 4 and Co-culture on Expression of Piwil2 Gene in Mouse Differentiated Embryonic Stem Cells [PDF]
International Journal of Fertility and Sterility, 2009 Background Specific growth factors and feeder layers seem to have important roles in in vitro embryonic stem cells (ESCs) differentiation. In this study,the effects of bone morphogenetic protein 4 (BMP4) and mouse embryonic fibroblasts (MEFs) co-culture ...
Zohreh Makoolati +2 more
doaj +1 more source
BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo
Biology Open, 2021 Human embryonic stem cells (hESCs) possess an immense potential to generate clinically relevant cell types and unveil mechanisms underlying early human development.
Sapna Chhabra, Aryeh Warmflash
doaj +1 more source
BMP4 aggravates mitochondrial dysfunction of HRMECs
Heliyon, 2023 Mitochondria are important places for the oxidative phosphorylation of glucose and the maintenance of cell oxidation and antioxidant stability. However, mitochondrial dysfunction causes cell dysfunction. Meanwhile, retinal vascular endothelial cell dysfunction may cause vascular inflammation, hemorrhage, angiogenesis, and other manifestations.
Yong Wang +9 more
openaire +3 more sources
Cell Death Discovery, 2022 Liver metastasis is the leading cause of death in colorectal carcinoma (CRC). However, little is known about the mechanisms of transferring effector messages between the primary tumor and the site of metastasis.
Yang Li +7 more
semanticscholar +1 more source
BMP4 Activation and Secretion Are Negatively Regulated by an Intracellular Gremlin-BMP4 Interaction [PDF]
Journal of Biological Chemistry, 2006 Bone morphogenetic protein 4 (BMP4) is a potent growth factor that is involved in many important biological processes. Regulation of the level of secreted mature BMP4 determines the biological effects of BMP4 on cells in the local microenvironment. Previous studies suggested that Gremlin, a member of DAN family proteins, antagonizes BMP4 activity by ...
Sun, Jianping +7 more
openaire +3 more sources
Cell Journal, 2020 Objective: Bone morphogenetic protein 4 (BMP4) and basic fibroblast growth factor (bFGF) play important roles in embryonic heart development.
Sanaz Hasani +3 more
doaj +1 more source
Cell Death Discovery, 2022 Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Xingchun Wang +6 more
doaj +1 more source
Neuro-Oncology, 2022 Background Glioblastoma (GBM) is the most aggressive primary brain tumor. Its cellular composition is very heterogeneous, with cells exhibiting stem-cell characteristics (GSCs) that co-determine therapy resistance and tumor recurrence. Bone Morphogenetic
I. Verploegh +11 more
semanticscholar +1 more source
International Journal of Cancer, 2021 The HOX genes are a group of highly conserved Homeobox‐containing genes that control the body plan organization during development. However, their contributions to tumorigenesis and tumor progression remain uncertain and controversial.
Fan Xu +13 more
semanticscholar +1 more source