Results 51 to 60 of about 52,292 (275)
SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development [PDF]
Journal of the American Society of Nephrology, 2008 Renal hypodysplasia (RHD) is characterized by reduced kidney size and/or maldevelopment of the renal tissue following abnormal organogenesis. Mutations in renal developmental genes have been identified in a subset of affected individuals. Here, we report the first mutations in BMP4 and SIX2 identified in patients with RHD.
Weber, Stefanie +17 more
openaire +3 more sources
BMP4 regulation of human trophoblast development
The International Journal of Developmental Biology, 2014 Since the derivation of human embryonic stem cells, and the subsequent generation of induced pluripotent stem cells, there has been much excitement about the ability to model and evaluate human organ development in vitro. The finding that these cells, when treated with BMP4, are able to generate the extraembryonic cell type, trophoblast, which is the ...
Li, Yingchun, Parast, Mana M
openaire +5 more sources
Are physiological oscillations physiological?
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley +1 more source
Accumulation of rare coding variants in genes implicated in risk of human cleft lip with or without cleft palate. [PDF]
, 2019 Cleft lip with/without cleft palate (CLP) is a common craniofacial malformation with complex etiologies, reflecting both genetic and environmental factors. Most of the suspected genetic risk for CLP has yet to be identified. To further classify risk loci
Asrani, Kripa +4 more
core +2 more sources
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus [PDF]
The EMBO Journal, 2004 Synexpression groups are genetic modules composed of genes that share both a complex expression pattern and the biological process in which they function. Here we investigate the regulation of BMP4 synexpression by studying the enhancers of bambi, smad7 and vent2 in Xenopus.
Emil, Karaulanov +2 more
openaire +2 more sources
JBMR Plus, 2020 Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation.
Marita Westhrin +15 more
doaj +1 more source
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. [PDF]
PLoS ONE, 2010 Bone marrow erythropoiesis is primarily homeostatic, producing new erythrocytes at a constant rate. However at times of acute anemia, new erythrocytes must be rapidly produced much faster than bone marrow steady state erythropoiesis.
Dai-Chen Wu, Robert F Paulson
doaj +1 more source
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]
, 2016 Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core +1 more source
Functional Concentrations of BMP4 on Differentiation of Mouse Embryonic Stem Cells to Primordial Germ Cells [PDF]
International Journal of Fertility and Sterility, 2011 Background Bone morphogenetic protein 4 (BMP4) has a significant role in primordial germ cells (PGCs) differentiation from mouse embryonic stem cell (mESC).
Hatef Ghasemi Hamidabadi +5 more
doaj
Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]
, 2009 Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates +60 more
core +5 more sources