Results 71 to 80 of about 46,344 (243)

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

Advanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang, Mingjie Kuang, Jiacheng Shi, Ruiyan Li, Yuhan Zhang, Xinting Liu, Runtan Li, Yong Kang, Bin Yao, Shuquan Zhang, Xiaoyuan Ji   +10 more
wiley   +1 more source

BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells

Cancer & Metabolism, 2023
Background Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest ability to promote glycogenesis among the 14 BMPs in hepatocytes and augmented hepatocellular carcinoma
Jiamin Zhong, Luyao Tian, Yannian Gou, Piao Zhao, Xiangyu Dong, Meichun Guo, Guozhi Zhao, Aohua Li, Ailing Hao, Tong-Chuan He, Jiaming Fan   +10 more
doaj   +1 more source

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis [PDF]

, 2015
The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage.
Blinka, Steven, Gundry, Rebekah, Horst, Audrey, Kim, Min-Su, Lough, John, Mahnke, Donna K., Schuman, James, Stamm, Karl D., Tomita-Mitchell, Aoy   +8 more
core   +4 more sources

Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal [PDF]

, 2018
Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC ...
Busch, Caroline, Copland, Mhairi, Jørgensen, Heather, Morrison, Heather, O'Brien, Stephen, Toofan, Parto, Wheadon, Helen   +6 more
core   +2 more sources

Bmp4 Promotes a Brown to White-like Adipocyte Shift [PDF]

Cell Reports, 2016
ISSN:2211 ...
Modica, Salvatore, Straub, Leon G., Balaz, Miroslav, Sun, Wenfei, Varga, Lukas, Stefanicka, Patrik, Profant, Milan, Simon, Eric, Neubauer, Heike, Ukropcova, Barbara, Ukropec, Jozef, Wolfrum, Christian   +11 more
openaire   +4 more sources

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract

Jornal de Pediatria, 2014
OBJECTIVE: To determine the frequency of different phenotypes for congenital anomalies of the kidney and urinary tract (CAKUT) in a Brazilian sample, and to evaluate the association between the CAKUT phenotypes and the BMP4 gene.
Geisilaine Soares dos Reis, Ana Cristina Simoes e Silva, Izabella Silva Freitas, Thiago Ramos Heilbuth, Luiz Armando de Marco, Eduardo Araujo Oliveira, Debora Marques Miranda   +6 more
doaj   +3 more sources

Noggin depletion in adipocytes promotes obesity in mice. [PDF]

, 2019
ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guo, Yina, Jumabay, Medet, Lusis, Aldons J, Rajbhandari, Prashant, Reue, Karen, Sallam, Tamer, Tontonoz, Peter, Vergnes, Laurent, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng, Zhang, Li   +14 more
core   +1 more source

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources