Results 41 to 50 of about 114,435 (209)
rhBMP‐2 has adverse effects on human oral carcinoma cell lines in vivo [PDF]
, 2011 Objectives/Hypothesis: To establish the relevance of the bone morphogenetic protein (BMP) signaling pathway in human oral squamous cell carcinoma (OSCCA) cell lines and determine if there is a biologic impact of stimulating this pathway with recombinant
Kokorina, Natalia A. +4 more
core +1 more source
Bone morphogenetic protein signaling promotes morphogenesis of blood vessels, wound epidermis, and actinotrichia during fin regeneration in zebrafish [PDF]
, 2015 Zebrafish fin regeneration involves initial formation of the wound epidermis and the blastema, followed by tissue morphogenesis. The mechanisms coordinating differentiation of distinct tissues of the regenerate are poorly understood.
Jaźwińska, Anna +4 more
core +1 more source
Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool
Stem Cell Reports, 2018 Summary: In developing organisms, proper tuning of the number of stem cells within a niche is critical for the maintenance of adult tissues; however, the involved mechanisms remain largely unclear.
Chen-Yuan Tseng +9 more
doaj +1 more source
BMP signaling and early embryonic patterning [PDF]
Cytokine & Growth Factor Reviews, 2005 Bone morphogenetic proteins (BMPs) play pleiotropic roles during embryonic development as well as throughout life. Recent genetic approaches especially using the mouse gene knockout system revealed that BMP signaling is greatly involved in early embryonic patterning, which is a dynamic event to establish three-dimensional polarities.
Satoshi, Kishigami, Yuji, Mishina
openaire +2 more sources
Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo.
PLoS Genetics, 2016 The BMP signaling pathway has a conserved role in dorsal-ventral axis patterning during embryonic development. In Drosophila, graded BMP signaling is transduced by the Mad transcription factor and opposed by the Brinker repressor.
Lisa Deignan +7 more
doaj +1 more source
Bone Research, 2022 Spondylocarpotarsal syndrome (SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions resulting from biallelic nonsense mutations in the gene encoding filamin B (FLNB).
Jennifer Zieba +8 more
doaj +1 more source
Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest [PDF]
, 2005 The Wnt signaling pathway is important in the formation of neural crest cells in many vertebrates, but the downstream targets of neural crest induction by Wnt are largely unknown. Here, we examined quantitative changes in gene expression regulated by Wnt-
Bronner, Marianne E., Taneyhill, Lisa A.
core +1 more source
Stem Cells: Keeping BMP Signaling Local [PDF]
Current Biology, 2011 In stem cell niches, the spatial extent of growth factor signaling needs to be tightly controlled. A new study on the Drosophila testicular germline stem cell niche has revealed that BMP signaling is locally activated through linkage to adherens junctions.
Ma, Xing, Xie, Ting
openaire +3 more sources
Molecular Therapy: Methods & Clinical Development, 2023 Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclinical
Aysegul Atasoy-Zeybek +5 more
doaj +1 more source
Interaktion der Ihh/Pthlh, BMP und FGF Signalwege in der Regulierung der Chondrozytenproliferation und Differenzierung [PDF]
, 2002 TITLE PAGE AND SUMMARY 0. CONTENTS I 1. INTRODUCTION 1 1.1 Skeleton of vertebrates 1 1.2 Endochondral ossification 2 1.3 Structure of developing cartilage 4 1.4 Different signaling pathways regulating bone development 5 1.4.1 Human ...
Minina, Eleonora
core +1 more source