Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency [PDF]
, 2015 Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation ...
Bloch, Donald B. +17 more
core +7 more sources
TGFβ/BMP Signaling Pathway in Cartilage Homeostasis [PDF]
Cells, 2019 Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by growth factors such as those of the transforming growth factor β (TGFβ) family.
Nathalie Thielen +2 more
openaire +5 more sources
BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning
Frontiers in Cell and Developmental Biology, 2021 One of the most significant events during early embryonic development is the establishment of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and left-right axes.
Yifang Yan +5 more
doaj +1 more source
Current perspectives of the signaling pathways directing neural crest induction. [PDF]
, 2012 The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I +1 more
core +2 more sources
The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling [PDF]
Nature, 2000 Dorsal-ventral patterning in vertebrate and Drosophila embryos requires a conserved system of extracellular proteins to generate a positional information gradient. The components involved include bone morphogenetic proteins (BMP/Dpp), a BMP antagonist (Chordin/Short gastrulation; Chd/Sog) and a secreted metalloproteinase (Xolloid/Tolloid) that cleaves ...
M, Oelgeschläger +3 more
openaire +2 more sources
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice.
PLoS ONE, 2009 Exposure to exercise or to environmental enrichment increases the generation of new neurons in the adult hippocampus and promotes certain kinds of learning and memory.
Kevin T Gobeske +6 more
doaj +1 more source
BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin
Cell Reports, 2020 Summary: Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning.
Rita Mateus +6 more
doaj +1 more source
The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster. [PDF]
PLoS Genetics, 2015 The developing crossveins of the wing of Drosophila melanogaster are specified by long-range BMP signaling and are especially sensitive to loss of extracellular modulators of BMP signaling such as the Chordin homolog Short gastrulation (Sog).
Justin Schleede, Seth S Blair
doaj +1 more source
Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells Under BMP4 and Noggin Influence [PDF]
, 2015 Although BMP4-induced differentiation of glioma stem cells (GSCs) is well recognized, details of the cellular responses triggered by this morphogen are still poorly defined.
Arakaki, Naomi +10 more
core +1 more source