Results 121 to 130 of about 21,955 (252)

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy [PDF]

, 2016
Alcohol ingestion decreases postexercise rates of muscle protein synthesis, but the mechanism(s) (e.g., increased protein breakdown) underlying this observation is unknown.
Burke LM, Donny M. Camera, Evelyn B. Parr, John A. Hawley, Orly Lacham-Kaplan, Vernon G. Coffey, William J. Smiles   +6 more
core   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Role of mitophagy in spinal cord ischemia-reperfusion injury

Neural Regeneration Research
Spinal cord ischemia-reperfusion injury, a severe form of spinal cord damage, can lead to sensory and motor dysfunction. This injury often occurs after traumatic events, spinal cord surgeries, or thoracoabdominal aortic surgeries.
Yanni Duan, Fengguang Yang, Yibao Zhang, Mingtao Zhang, Yujun Shi, Yun Lang, Hongli Sun, Xin Wang, Hongyun Jin, Xuewen Kang   +9 more
doaj   +1 more source

BNIP3 decreases the LPS-induced inflammation and apoptosis of chondrocytes by promoting the development of autophagy

Journal of Orthopaedic Surgery and Research, 2020
Background Inflammation and apoptosis of chondrocytes are the pathological bases of osteoarthritis. Autophagy could alleviate the symptoms of inflammation and apoptosis. Previous study has shown that BCL2/adenovirus E1B 19 kDa protein-interacting protein
Zetao Ma, Deli Wang, Jian Weng, Sheng Zhang, Yuanshi Zhang   +4 more
doaj   +1 more source

Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells [PDF]

, 2008
Background Hypoxia inducible factor-1 (HIF-1) is a transcription factor that functions to maintain cellular homeostasis in response to hypoxia.
Ricky Malhotra, David W Tyson, Henry M Rosevear, Frank C Brosius, GL Wang, GL Semenza, GL Semenza, JK Brunelle, DS McClintock, K Yamamoto, J Marin-Garcia, P Carmeliet, S Krick, RM Graham, JP Piret, AE Greijer, RK Bruick, N Akakura, JT Erler, J Chen, J-P Piret, S Dai, R Malhotra, Z Lin, RD Loberg, R Malhotra, W Gao, B-H Jiang, A Reynolds, YT Hsu, M Van Hoecke, HM Sowter, RK Bruick, WG An, G Wright, T Date, R Natarajan, JC Rathmell, JJ Lum, MR Morisette, AB Stein, TL Vanden Hoek, DJ Thuerauf, DT Rutkowski, HP Harding, T Ozawa, T Tanaka, D Chen, WX Ding, J Cheng, KD Mansfield, NS Chandel, L Zhang   +52 more
core   +1 more source

Mediterranean Versus Western Diet Effects on Obesity Phenotypes and Adipose Tissue Transcriptional Profiles in Female Monkeys

Obesity, Volume 34, Issue 3, Page 641-651, March 2026.
ABSTRACT Objective Obesity, or excessive body fat, is a significant health risk factor. Western diets (WD) contribute to metabolic dysfunction and obesity, while Mediterranean diets (MD) improve metabolic health. This study examined the contrasting effects of WD versus MD on visceral and subcutaneous adipose tissues (VAT, SAT) using a randomized ...
Aya Jamal Abusheikha, Corbin S. C. Johnson, Noah Snyder‐Mackler, Kip D. Zimmerman, Brett M. Frye, Carol A. Shively, Thomas C. Register   +6 more
wiley   +1 more source

The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis. [PDF]

, 2018
Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy with a variable clinical outcome. Biomarkers of CLL progression are required for optimising prognosis and therapy.
Albano, F., Chiurazzi, F., Cimmino, C., Fiume, G., Frieri, C2, Golino, G., Iaccino, E., Mallardo, M., Mimmi, S., Pastore, A., Pisano, A., Quinto, I., Scala, G., Vecchio, E.   +13 more
core   +2 more sources

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes [PDF]

, 2016
The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions.
Nakatsuka, Atsuko, Wada, Jun
core   +1 more source

Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress [PDF]

, 2015
In cardiac ischemia-reperfusion injury, reactive oxygen species (ROS) generation and upregulation of the hypoxia-inducible protein BNIP3 result in mitochondrial permeabilization, but impairment in autophagic removal of damaged mitochondria provokes ...
Abulrqeba, Haedar, Barger, Philip M, Diwan, Abhinav, Foyil, Sarah R, Godar, Rebecca J, Liu, Halyan, Ma, Xlucul, Murphy, John T, Weinheimer, Carla J   +8 more
core   +2 more sources