Results 121 to 130 of about 19,187 (211)
6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Background Cardiomyocytes loss is the predominant pathogenic characteristic in the hypoxia-induced injury. Meanwhile, it has been corroborated that Bcl-2 E1B 19-KDa interacting protein 3 (BNIP3) provokes apoptosis and autophagy.
Qi Ren, Shaojun Zhao, Changjie Ren
doaj +1 more source
The Effect of a Western Diet on Hepatic Autophagy in Age Accelerated SAMP8 Mice [PDF]
, 2017 Non-alcoholic steatohepatitis (NASH) is characterized as a dysregulation of hepatic lipid metabolism and a chronic inflammatory state. It is hypothesized the link between lipid dysregulation and inflammation may be due in part to defective hepatic ...
Harris, Matthew P +5 more
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Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
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C12orf5 (chromosome 12 open reading frame 5) [PDF]
, 2018 Review on C12orf5, with data on DNA/RNA, on the protein encoded and where the gene is ...
Bartrons Bach, Ramon +5 more
core +1 more source
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis [PDF]
, 2004 Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and ...
Greijer, A.E., Wall, E. van der
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Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma [PDF]
, 2014 Background: Basal cell carcinoma (BCC) is the most common cancer in Caucasians. Trichoepithelioma (TE) is a benign neoplasm that strongly resembles BCC. Both are hair follicle (HF) tumours.
AH Arits +47 more
core +4 more sources
Cell Death and DiseaseMitophagy is a selective process that targets the damaged, dysfunctional, or superfluous mitochondria for degradation through autophagy. The SCFFBXL4 E3 ubiquitin ligase complex suppresses basal mitophagy by targeting BNIP3 and BNIP3L, two key mitophagy ...
Xiayun Xu +9 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2011 Autophagy plays diverse roles in Ras-related tumorigenesis. H-rasval12 induces autophagy through multiple signaling pathways including Raf-1/ERK pathway, and various ERK downstream molecules of autophagy have been reported.
Shan-Ying Wu +7 more
doaj +1 more source
BNIP3-dependent mitophagy role in cisplatin resistance
Autophagy Reports, 2022 Cocetta V. +3 more
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Coordinating BNIP3/NIX-mediated mitophagy in space and time
Biochemical Society TransactionsMitochondria maintain organellar homeostasis through multiple quality control pathways, including the clearance of defective or unwanted mitochondria by selective autophagy. This removal of mitochondria, mitophagy, is controlled in large part by the outer mitochondrial membrane mitophagy receptors BNIP3 and NIX.
Natalie M. Niemi, Jonathan R. Friedman
openaire +2 more sources