Results 131 to 140 of about 21,955 (252)

Lipin‐1 regulates Bnip3–mediated mitophagy in glycolytic muscle

The FASEB Journal, 2018
ABSTRACT Autophagy of mitochondria (mitophagy) is essential for maintaining muscle mass and healthy skeletal muscle. Patients with heritable phosphatidic acid phosphatase lipin‐1–null mutations present with severe rhabdomyolysis and muscle atrophy in glycolytic muscle fibers, which are accompanied with ...
Abdullah A, Alshudukhi, Jing, Zhu, Dengtong, Huang, Abdulrahman, Jama, Jeffrey D, Smith, Qing Jun, Wang, Karyn A, Esser, Hongmei, Ren   +7 more
openaire   +3 more sources

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation

BMC Neuroscience, 2009
Background Caspase-independent apoptotic pathways are suggested as a mechanism for the delayed neuronal death following ischemic insult. However, the underlying signalling mechanisms are largely unknown.
Bean Jonathan C, Das Manas, Li Bo-Xing, Zhang Ming-Hai, Li Shu-Ji, Chen Ming, Zhao Shen-Ting, Kong Ji-Ming, Zhu Xin-Hong, Gao Tian-Ming   +9 more
doaj   +1 more source

Autophagy induced by hypoxia in pulpitis is mediated by HIF-1α/BNIP3.

Archives of Oral Biology
OBJECTIVE Hypoxia-inducible factor-1α (HIF-1α) and its downstream factor, 19 kDa BCL-2 interacting protein 3 (BNIP3), promote cellular autophagy under hypoxic conditions. However, their roles in pulpitis are unclear.
Xiaohe Wang, Zeyu Wu, Yangyang Zhang, Bingjie Lian, Li Ma, Jin Zhao   +5 more
semanticscholar   +1 more source

Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration

Aging
Mitophagy is a selective form of autophagy which permits the removal of dysfunctional or excess mitochondria. This occurs as an adaptative response to physiological stressors, such as hypoxia, nutrient deprivation, or DNA damage. Mitophagy is promoted by
Marta Mauro-Lizcano, F. Sotgia, Michael P. Lisanti   +2 more
semanticscholar   +1 more source

Prolyl hydroxylase inhibitor FG-4592 alleviates neuroinflammation via HIF-1/BNIP3 signaling in microglia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
BACKGROUND Neuroinflammation is responsible for neuropsychiatric dysfunction following acute brain injury and neurodegenerative diseases. This study describes how a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor FG-4592 prevents the ...
Qian-Qian Ruan, Yanan Geng, Ming Zhao, Heyang Zhang, Xiang Cheng, Tong Zhao, Xiangpei Yue, Xiufang Jiang, Xiaoxia Jiang, Xiao-Yu Hou, Lingling Zhu   +10 more
semanticscholar   +1 more source

6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Background Cardiomyocytes loss is the predominant pathogenic characteristic in the hypoxia-induced injury. Meanwhile, it has been corroborated that Bcl-2 E1B 19-KDa interacting protein 3 (BNIP3) provokes apoptosis and autophagy.
Qi Ren, Shaojun Zhao, Changjie Ren
doaj   +1 more source

Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase [PDF]

, 2015
There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1.
Nishimura, Ryo, Okuda, Kiyoshi
core   +1 more source

Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210 [PDF]

, 2015
Background Autophagy participates in innate immunity by eliminating intracellular pathogens. Consequently, numerous microorganisms have developed strategies to impair the autophagic machinery in phagocytes.
de Oliveira Almeida Petersen, Antonio Luis, Frank, Benjamin, Marcu, Ana, Mottram, Jeremy C., Scholz, Claus Jürgen, Schurigt, Uta, Stigloher, Christian, Weber, Heike   +7 more
core   +3 more sources

αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury

Cellular and Molecular Life Sciences
Contrast-induced acute kidney injury (CI-AKI) is one of the main causes of hospital-acquired renal failure, and still lacks of effective treatments. Previously, we demonstrated that αKlotho, which is an anti-aging protein that highly expresses in the ...
Xuying Zhu, Q. Lin, Yuanting Yang, Shu Li, Xinghua Shao, Weiming Zhang, Hong Cai, Jialin Li, Jingkui Wu, Kaiqi Zhang, Chao-jun Qi, Min-fang Zhang, Xiajing Che, Leyi Gu, Zhaohui Ni   +14 more
semanticscholar   +1 more source

Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma [PDF]

, 2014
Background: Basal cell carcinoma (BCC) is the most common cancer in Caucasians. Trichoepithelioma (TE) is a benign neoplasm that strongly resembles BCC. Both are hair follicle (HF) tumours.
AH Arits, AM Arsham, Ariënne M. van Marion, BG Wouters, Björn G. Lohman, CC Wykoff, Chantal A. H. Weijzen, D Krahl, DA Chan, DA Fruman, DG Hardie, G Chinnadurai, G D'Angelo, G Karayannopoulou, GG Chiang, GL Semenza, HM Zhang, J Bowden, J Brugarolas, JJ Rippey, Jonathan Eben, K Duvel, K Nakayama, K Nys, K Ruan, KK Youssef, LS Liu, M Kasper, MA van Steensel, Maurice A. M. van Steensel, Monique R. Thissen, NS Vasudev, O Sedlakova, O Warburg, P Sadlecki, Patty J. Nelemans, R Toth-Jakatics, S Chen, SC Flohil, SH Jee, SJ Chen, SM Evans, Sonia Rocha, T Jokilehto, Tjinta Brinkhuizen, Véronique J. L. Winnepenninckx, W Weninger, Y Yang   +47 more
core   +4 more sources