Results 201 to 210 of about 19,187 (211)

An unexpected journey for BNIP3

Autophagy
Mitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for degradation. These tagged mitochondria are engulfed by specialized structures called phagophores that then mature into autophagosomes/mitophagosomes ...
José M Delgado, Christopher J Shoemaker
openaire   +2 more sources

BNIP3 induces apoptosis and protective autophagy under hypoxia in esophageal squamous cell carcinoma cell lines: BNIP3 regulates cell death

Diseases of the Esophagus, 2017
Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP3), a pro-apoptosis protein regulated by the methylation status of its promoter, has been implicated in inducing autophagy. However, the roles of BNIP3 and BNIP3-induced autophagy under hypoxia remain uncertain in esophageal squamous cell carcinoma (ESCC).
Z, Ma, C, Chen, P, Tang, H, Zhang, J, Yue, Z, Yu   +5 more
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VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells

Angiogenesis, 2011
Hypoxia results in the apoptotic death of myocytes, neurons, and epithelial cells, through the actions of Bcl-2 and Nineteen kilodalton Interacting Protein-3 (BNIP3). On the contrary, endothelial cells are especially adept at surviving conditions of oxygen deprivation via up-regulation of vascular endothelial growth factor (VEGF) the most potent ...
Paul, Jurasz, Natasha, Yurkova, Lorrie, Kirshenbaum, Duncan J, Stewart   +3 more
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H-ras up-regulates expression of BNIP3.

Anticancer research, 2011
Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3) is a key regulator of cell death/autophagy and can act as an effector of a necrosis-like, atypical death program. It was implicated in execution of cell death induced by cluster of differentiation 47 (CD47).
Wojciech, Kalas, Ewelina, Swiderek, Andrzej, Rapak, Magdalena, Kopij, Janusz, Rak, Leon, Strzadala   +5 more
openaire   +2 more sources

BNip3 and signal-specific programmed death in the heart

Journal of Molecular and Cellular Cardiology, 2005
The BH3-only proteins, including BNip3, are members of the Bcl-2 family of cell death-regulating factors. Whereas proteins such as Bax and Bak play a central role in most forms of apoptosis, the BH3-only proteins appear to modulate apoptosis through cell type- and signal-specific pathways.
Keith A, Webster, Regina M, Graham, Nanette H, Bishopric   +2 more
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Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3

Biochemical and Biophysical Research Communications, 2008
An angiogenic factor, thymidine phosphorylase (TP), confers resistance to apoptosis induced by hypoxia. We investigated the molecular basis for the suppressive effect of TP on hypoxia-induced apoptosis using Jurkat cells transfected with TP cDNA, Jurkat/TP, and a mock transfectant, Jurkat/CV.
Ryuji, Ikeda, Yusuke, Tajitsu, Ken-Ichi, Iwashita, Xiao-Fang, Che, Kenichi, Yoshida, Mina, Ushiyama, Tatsuhiko, Furukawa, Masaharu, Komatsu, Tatsuya, Yamaguchi, Yoshihiko, Shibayama, Masatatsu, Yamamoto, Hong-Ye, Zhao, Junko, Arima, Yasuo, Takeda, Shin-Ichi, Akiyama, Katsushi, Yamada   +15 more
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BNIP3 up-regulation and mitochondrial dysfunction in manganese-induced neurotoxicity

NeuroToxicology, 2009
The central nervous system (CNS) appears to be the critical target of manganese (Mn), and neurotoxicity has been the focus of most of the health effects of manganese. In brain, the mechanism underlying the Mn-induced cell death is not clear. We have previously demonstrated that NFkappabeta induction and the activation of nitric oxide synthase through ...
Krishnan, Prabhakaran, Gail D, Chapman, Palur G, Gunasekar   +2 more
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Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy

2017
Mitochondria are organelles with numerous vital roles in cellular metabolism. Impaired or damaged mitochondria are degraded in autophagolysosomes in a process known as mitophagy. Given the fundamental role of mitophagy in maintenance of cellular homeostasis, methods and techniques with which to study this process are constantly evolving and emerging ...
Matilda, Šprung, Ivan, Dikic, Ivana, Novak   +2 more
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Functions of BNIP3 in Nutrient Stress Responses

2019
BNIP3 is a mitophagy receptor that targets mitochondria for degradation at the autophagolysosome. By mediating mitophagy, BNIP3 functions to decrease mitochondrial mass as an adaptive response to stress, namely hypoxia and nutrient starvation. This catabolic mechanism prevents the accumulation of damaging reactive oxygen species that are normally ...
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BNIP3 как регулятор цисплатин-индуцированного апоптоза

Биохимия, 2020
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