Results 211 to 220 of about 76,436 (252)

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Engineering fibroblast with reprogramming and spheronization for bone defect repair. [PDF]

Bioact Mater
Li Y, Jiang B, Wu Z, Ma Z, Qiu L, Cui W, Zhao Y, Yan J, Ma D, Wu X, Liang S, Wang S, Zhao Y, Wang M, Hu M.   +14 more
europepmc   +1 more source

A bioprinted periosteum organoid enables functional repair of critical-sized bone defects

Zhengrong Chen, Kui Huang, Z H Zhang, Peng Chen, Qixiu Yu, Yong Tang, Jiulin Tan, Jie Zhang, Ying Qu, Qijie Dai, Shiwu Dong, Fei Luo, Ce Dou   +12 more
openalex   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles combined with injectable hydrogels in bone defect repair: a systematic review and meta-analysis of preclinical studies. [PDF]

J Biol Eng
Aghayan AH, Mohammadi D, Samarkhazan HS, Atashi A, Jamalpoor Z.   +4 more
europepmc   +1 more source

Use of honey-derived silver nanoparticles associated with low-level laser therapy for bone defect repair in rats

Armélio Vasconcelos de Siqueira Neto, Ana Claudia Souza Abreu, Carla Beatriz dos Santos Torres, Mônica Patrícia de Sousa Rêgo, Hugo C. Braga, Alan Kelbis Oliveira Lima, Emerson Cristi de Barros, Kashif Gul, José Arnaldo Santana Costa, Arthur Abinader Vasconcelos, Donald A. Fernandes, Paulo Sérgio Taube   +11 more
openalex   +1 more source

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

Advanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang, Juan Li, Miao‐Miao Yang, Chao Jia, Quan‐Xin Gong, Guang‐Cheng Yuan, Dong Zhou, Wen‐Hui Shen, Zeng‐Gan Chen, Zhi‐Rui Dong, Jin‐Wang Huang, Jie Peng, Di‐Han Su, Ming‐Dong Zhao, Jian Dong, Li‐Bo Jiang   +15 more
wiley   +1 more source

Dynamic hydrogels orchestrate the differentiation fate of mesenchymal stem cells through epigenetic regulation of SETD7 to accelerate bone defect repair. [PDF]

Bioact Mater
Xie X, Hu L, Zhang Y, Mi B, Xu X, Ding C, Li Y, Al-Smadi F, Chu X, Xiong Y, Zhang K, Bian L, Liu G.   +12 more
europepmc   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Hierarchical periosteum-bone composite scaffold with staged release of dexamethasone and endothelial cell derivatives for efficient critical-sized bone defect repair. [PDF]

Mater Today Bio
Yu C, Wang Y, Xie L, He Q, Yu T, Wu T.
europepmc   +1 more source