Results 221 to 230 of about 76,436 (252)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Bioscaffold materials resist infection and promote bone defect repair by regulating neutrophil function. [PDF]

Front Bioeng Biotechnol
Zhou J, Xiong S, Liu S, Zhou Z, Liu M, Xi H, Kong W, Zhou J, Xiong L.   +8 more
europepmc   +1 more source

IMPACT OF VITAMIN A OVERDOSE ON BONE MINERAL DENSITY AND REPAIR IN FEMORAL CRITICAL- SIZED DEFECT

Nada Reda Desouly, hany sherif, Iman Fathy   +2 more
openalex   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Osteogenesis-synchronized degradation of Mg²⁺-doped calcium sulfate whisker bone grafts for critical-sized bone defect repair. [PDF]

Biomed Eng Online
Li C, Shi Z, Li X, Yang Y, Zhang L, Yan T, Yang H.   +6 more
europepmc   +1 more source

Piezoelectric hydrogel-based 3D bioprinting of cartilage-bone integrated organoids for osteochondral defect repair

Jian Wang, Haitao Zhang, Dongyang Zhou, Xukun Lyu, Zhenglin Dong, Xiaoxiang Ren, Guangfeng Li, Jianhua Wang, Yingying Jing, Yuxiao Lai, Zhen Geng, Lu Bai, Xiao Chen, Jiacan Su   +13 more
openalex   +1 more source

Corrigendum to 'Icariin-loaded GelMa hydrogel encapsulated potassium sodium niobate biomimetic piezoelectric scaffold regulates macrophage polarization to accelerate bone defect repair' [Mater. Today Bio 35 (2025) 102476]. [PDF]

Mater Today Bio
Wang Y, Zhang H, Xu Z, Zhu W, Chang S, Wei J, Chen S, Liu Y, Kong W, Guo J.   +9 more
europepmc   +1 more source

3D-printed graphene oxide/bioactive glass/BMP-2 composite scaffolds enhance osteogenesis in bone defect repair

Mingkai Qin, Qi Li, Ruiqi Zhao, Zhang H, Z Y Li, Guizhen Xiang, Xusheng Yan, Weiguo Sun   +7 more
openalex   +1 more source

Platelet Lysate-Enriched Human Induced Pluripotent Stem Cell-Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification. [PDF]

Adv Healthc Mater
Chen Y, Lin J, Li J, Hu Y, Su J, Miao Y, Wang L, Tang Q, Zhang C, Yin J.   +9 more
europepmc   +1 more source

Aptamer-functionalized tetrahedral framework nucleic acid delivery of siBhlhe22 for repairing osteoporotic bone defects via dual modulation of PI3K-Akt signaling and purine metabolism

Qiaonan Ye, Long Bai, Gao Y, Shiyi Zeng, Z Zhang, Yong Li, Qianke Tao, M Zhang, Y Y Lin, J N Xiao   +9 more
openalex   +1 more source