Results 11 to 20 of about 125,148 (266)

Osteogenesis of bone marrow mesenchymal stem cell in hyperglycemia

Frontiers in Endocrinology, 2023
Diabetes mellitus (DM) has been shown to be a clinical risk factor for bone diseases including osteoporosis and fragility. Bone metabolism is a complicated process that requires coordinated differentiation and proliferation of bone marrow mesenchymal stem cells (BMSCs). Owing to the regenerative properties, BMSCs have laid a robust foundation for their
Meng Luo, Meng Luo, Zhihe Zhao, Zhihe Zhao, Jianru Yi, Jianru Yi   +5 more
openaire   +3 more sources

Human bone marrow-derived mesenchymal stem cells [PDF]

Libyan Journal of Medicine, 2007
Mesenchymal stem cells (MSCs) have elicited a great clinical interest, particularly in the areas of regenerative medicine and induction of tolerance in allogeneic transplantation. Previous reports demonstrated the feasibility of transplanting MSCs, which generates new prospects in cellular therapy.
Lopez M, El-Taguri A, Fouillard L, Nasef A   +3 more
openaire   +4 more sources

Human bone marrow mesenchymal stem cells in vivo [PDF]

Rheumatology, 2007
Great confusion still exists amongst cell biologists, musculoskeletal and other specialists interested in regenerative medicine regarding the in vivo identity of human bone marrow (BM) mesenchymal stem cells (MSCs). Contrary to views held in some quarters, methods for the robust identification and purification of BM MSCs are now well established. Human
E, Jones, D, McGonagle
openaire   +2 more sources

Immunomodulatory properties of bone marrow mesenchymal stem cells

Journal of Biosciences, 2020
Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent progenitor cells of mesodermal origin possessing multilineage differentiation potential and ease of expansion in vitro. Over the years, these cells have gained attention owing to their potential in cell-based therapies in treating various diseases.
Mohanty, Aparna, Polisetti, Naresh, Vemuganti, Geeta K   +2 more
openaire   +3 more sources

Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells [PDF]

Stem Cells International, 2016
Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs) and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between adipogenesis and osteoblastogenesis in BMMSCs wherein adipogenesis is increased relative to osteoblastogenesis are associated ...
Shoichiro Kokabu, Jonathan W. Lowery, Eijiro Jimi   +2 more
openaire   +3 more sources

Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells [PDF]

Cells, 2021
The use of stem cells is part of a strategy for the treatment of a large number of diseases. However, the source of the original stem cells for use is extremely important and determines their therapeutic potential. Mesenchymal stromal cells (MSC) have proven their therapeutic effectiveness when used in a number of pathological models.
Valentina A. Babenko, Denis N. Silachev, Tatyana I. Danilina, Kirill V. Goryunov, Irina B. Pevzner, Ljubava D. Zorova, Vasily A. Popkov, Valery P. Chernikov, Egor Y. Plotnikov, Gennady T. Sukhikh, Dmitry B. Zorov   +10 more
openaire   +3 more sources

Chitosan-collagen porous scaffold and bone marrow mesenchymal stem cell transplantation for ischemic stroke

Neural Regeneration Research, 2015
In this study, we successfully constructed a composite of bone marrow mesenchymal stem cells and a chitosan-collagen scaffold in vitro, transplanted either the composite or bone marrow mesenchymal stem cells alone into the ischemic area in animal models,
Feng Yan, Wei Yue, Yue-lin Zhang, Guo-chao Mao, Ke Gao, Zhen-xing Zuo, Ya-jing Zhang, Hui Lu   +7 more
doaj   +1 more source

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Stem Cell Research & Therapy, 2022
Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells are still ...
Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, Teresa K. Tarrant   +17 more
doaj   +1 more source

Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow–derived counterparts

Journal of Tissue Engineering, 2016
In this study, we show that matrix dense cortical bone is the more potent compartment of bone than bone marrow as a stromal source for mesenchymal stem cells as isolated from adult rats. Lineage-depleted cortical bone-mesenchymal stem cells demonstrated >
Daniel Blashki, Matthew B Murphy, Mauro Ferrari, Paul J Simmons, Ennio Tasciotti   +4 more
doaj   +1 more source

Bone marrow mesenchymal stem cells in hepatocellular carcinoma

Frontiers in Bioscience, 2013
Bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic multipotent stem cells capable of differentiating into mature cells. Studies in animal models have indicated that hepatocellular carcinoma (HCC) may originate from genetically mutated BMSCs.
Peng, Gong, Yingxin, Wang, Jing, Zhang, Zhongyu, Wang   +3 more
openaire   +2 more sources