Results 111 to 120 of about 1,264,713 (295)

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Spatiotemporally adaptive metal-gas nanotherapy: Acid-triggered cascade release for osteoporosis treatment

Bioactive Materials
The treatment of osteoporosis remains a critical challenge due to the limitations of current therapies in simultaneously restoring homeostasis of bone metabolism and modulating the chronic inflammation of bone microenvironment.
Wei Xiong, Yiming Hu, Changxiong Cai, Xingyun Fang, Ye Liu, Xiangyu Tian, Qingsong Ye, Xigao Cheng, Jing Ye   +8 more
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

New acquisitions in the physiopathology of multiple myeloma: role of the bone microenvironment Novos conhecimentos da fisiopatologia do mieloma múltiplo: o papel do microambiente medular

Revista Brasileira de Hematologia e Hemoterapia, 2008
Multiple myeloma (MM) is a plasma cell malignancy characterized by the accumulation of malignant plasma cells within the bone marrow (BM). MM cells interact with the microenvironment and induce pathological modifications that in turn support the growth ...
Nicola Giuliani, Vittorio Rizzoli
doaj  

Research progress in the differentiation and function of osteoclasts in the inflammatory microenvironment

Kouqiang hemian waike zazhi
Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption. Inflammation serves as a significant inducer of pathological bone resorption.
WANG Jin, WANG Yabing, SU Jiansheng
doaj   +1 more source

Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer

Neoplasia: An International Journal for Oncology Research, 2005
Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DOcollagen I (a bone matrix protein) and, for comparison, DO-collagen IV, by living human prostate carcinoma cells in vitro.
Izabela Podgorski, Bruce E. Linebaugh, Mansoureh Sameni, Christopher Jedeszko, Sunita Bhagat, Michael L. Cher, Bonnie F. Sloane   +6 more
doaj   +1 more source

Notochordal inclusions in the vertebral bone marrow

, 2008
Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment.
Ernesto Ippolito, IPPOLITO, ERNESTO, BIANCO, Paolo, MANCINI F, RIMINUCCI, MARA, CORSI, ALESSANDRO, Bianco, P, Mancini, F, Fernando De Maio, De Maio, F, Riminucci, M, Bianco, P., Federico Mancini, DE MAIO, FERNANDO, MANCINI, FEDERICO, Alessandro Corsi, IPPOLITO E, Ippolito, E, Corsi, A, DE MAIO F, Mara Riminucci, Paolo Bianco   +21 more
core   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis

Frontiers in Endocrinology, 2019
The bone represents surprisingly dynamic structures that are subject to constant remodeling by the concerted action of bone-forming osteoblasts and bone-resorbing osteoclasts - two cell subsets of distinct developmental origin that are key in maintaining
Luise Fischer, Luise Fischer, Caroline Herkner, Reni Kitte, Sebastian Dohnke, Sebastian Dohnke, Julia Riewaldt, Karsten Kretschmer, Annette I. Garbe   +8 more
doaj   +1 more source

Correlations between cancellous bone architecture and its dynamic behaviour [PDF]

, 2014
Previous studies showed that in vivo evaluation of the fracture risk of cancellous bone can be assessed by identifying the relationships between its microarchitecture description extracted from clinical imaging and its mechanical properties.
LAPORTE, Sébastien, SALETTI, Dominique, PATTOFATTO, Stéphane, BOUSSON, Valérie, PROT, Marianne   +4 more
core