Results 121 to 130 of about 1,264,713 (295)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source

Immunosuppressive Tumor Microenvironment of Osteosarcoma. [PDF]

Background/Objectives: Osteosarcoma is the most common malignant bone tumor in children, characterized by a high degree of genomic instability, resulting in copy number alterations and genomic rearrangements without disease-defining recurrent mutations ...
Taylor, Aaron M, Aaron Michael Taylor, Flynn, William F, Silvia Regina Caminada de Toledo, Bang Hoang, Robson, Paul, Paolillo, Alini Trujillo, Paul Robson, Qian Wu, Masanori Hayashi, Bodlak, Avery, Dzis, Alissa M, Alissa M. Dzis, Fabiola Sara Balarezo, Patrick Kwok Shing Ng, Balarezo, Fabiola Sara, Luo, Diane, Kumar, Parveen, Hayashi, Masanori, Hoang, Bang, Lindsay, Adam D, Caminada de Toledo, Silvia Regina, Nathaniel L. Jillette, Petrilli, Antonio Sergio, Adam D. Lindsay, Lau, Ching C, Diane Luo, Elise T. Courtois, Goodspeed, Andrew, Michael S. Isakoff, Stephen T. C. Wong, Cao, Yuliang, Ju Young Ahn, Andrew Goodspeed, Jessica D. S. Grassmann, Wong, Stephen T C, Isakoff, Michael S, Ching C. Lau, Ahn, Ju Young, Jillette, Nathaniel L, Grassmann, Jessica D S, Harder, Jeffrey M, Jeffrey M. Harder, William F. Flynn, Jianting Sheng, Parveen Kumar, Courtois, Elise T, Wu, Qian, Yuliang Cao, Antonio Sergio Petrilli, Joshy George, Avery Bodlak, George, Joshy, Sheng, Jianting, Ng, Patrick Ks, Alini Trujillo Paolillo   +55 more
core   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Microenvironment engineering of osteoblastic bone metastases reveals osteomimicry of patient-derived prostate cancer xenografts

, 2019
Representative in vitro models that mimic the native bone tumor microenvironment are warranted to support the development of more successful treatments for bone metastases.
Shokoohmand, A, Chetty, N, Smith, D, Atack, Anthony, Shafiee, Abbas, Baldwin, J, Theodoropoulos, C, Williams, ED, Bock, N, Bray, LJ, Chetty, Naven, Theodoropoulos, Christina, Ren, Jiongyu, Ren, J, Bray, Laura J., Atack, A, Pollock, PM, Williams, Elizabeth D., Tran, PA, Pollock, Pamela M., Shafiee, A, Wille, ML, Shokoohmand, Ali, Baldwin, Jeremy, Bock, Nathalie, Clements, JA, Tran, Phong A., Wille, Marie-Luise, Clements, Judith A., Hutmacher, Dietmar W., Hutmacher, DW, Smith, Deborah   +31 more
core   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Bone 3: Black Market International [PDF]

, 2000
Card for Black Market International at Bone 3: Performance Art Festival at Schlachthaus Theater, Bern, Switzerland.

core  

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source