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Biological effects of cabozantinib on bone microenvironment.
Journal of Clinical Oncology, 2016e23004Background: Cabozantinib (CBZ) is a receptor tyrosine kinase inhibitor with activity against MET, VEGFR2, FLT3, c-KIT, and RET.
Pantano, Francesco +6 more
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Targeting the Bone Marrow Microenvironment
2016Unprecedented advances in multiple myeloma (MM) therapy during the last 15 years are predominantly based on our increasing understanding of the pathophysiologic role of the bone marrow (BM) microenvironment. Indeed, new treatment paradigms, which incorporate thalidomide, immunomodulatory drugs (IMiDs), and proteasome inhibitors, target the tumor cell ...
Michele, Moschetta +2 more
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Metastasis in the Bone Marrow Microenvironment
2004Although metastatic growth of non-skeletal cancer in bone as an organ is commonly referred to as bone metastasis, any metastasis to bone is in fact a metastasis to the bone marrow. The extensive changes induced by cancer metastasis in bone (either lytic, or more rarely, sclerotic) represent secondary changes induced to fulfill the need of cancer cells ...
BIANCO, Paolo +2 more
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Extracellular vesicle-mediated bone metabolism in the bone microenvironment
Journal of Bone and Mineral Metabolism, 2017Extracellular vesicles (EVs) are phospholipid membrane-enclosed entities containing specific proteins, RNA, miRNA, and lncRNA. EVs are released by various cells and play a vital role in cell communication by transferring their contents from the host cells to the recipient cells.
Qi, Li +3 more
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Bone microenvironment signals in osteosarcoma development
Cellular and Molecular Life Sciences, 2015The bone is a complex connective tissue composed of many different cell types such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic cells and endothelial cells, among others. The interaction between them is finely balanced through the processes of bone formation and bone remodeling, which regulates the ...
Arantzazu, Alfranca +8 more
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The Lymphopoietic Microenvironment in Bone Marrow
1990Publisher Summary Various components of the lymphopoietic microenvironment can be grown in culture, where they can be dissected, characterized, and independently manipulated. Dexter cultures favor survival of multipotential stem cells and active production of granulocytes and macrophages.
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The Bone Marrow Microenvironment in Waldenström Macroglobulinemia
Hematology/Oncology Clinics of North America, 2018Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment.
Shahrzad, Jalali, Stephen M, Ansell
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Bone marrow microenvironment in Waldenstrom's Macroglobulinemia
Best Practice & Research Clinical Haematology, 2016Waldenstrom Macroglobulinemia (WM) is a low-grade B-cell lymphoma defined firstly by infiltration of lymphoplasmacytic cells into the bone marrow (BM), the milieu where the cells acquire signals that promote malignant growth and proliferation. A second characteristic associated with WM is the increased synthesis of monoclonal immunoglobulin M (IgM) by ...
Shahrzad, Jalali, Stephen M, Ansell
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Bone marrow microenvironment of MPN cells
2021In this chapter, we will discuss the current knowledge concerning the alterations of the cellular components in the bone marrow niche in Myeloproliferative Neoplasms (MPNs), highlighting the central role of the megakaryocytes in MPN progression, and the extracellular matrix components characterizing the fibrotic bone marrow.
Malara A. +3 more
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Detection of Hypoxic Regions in the Bone Microenvironment
2020Oxygen serves as a critical environmental factor essential for maintaining the physiological state of a tissue. Hypoxia, or low oxygen, triggers a cascade of events which allows for cells to adapt to low oxygen tensions and to facilitate oxygen delivery required to maintain tissue homeostasis. In the bone microenvironment (BME), vascular heterogeneity,
Wendi, Guo, Colleen, Wu
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